Children with fracture history have lower vitamin D levels – June 2016

Serum 25-hydroxyvitamin D status among Saudi children with and without a history of fracture.

J Endocrinol Invest. 2016 Jun 16. https://doi.org/10.1007/s40618-016-0496-7
Al-Daghri NM1,2, Aljohani N3,4, Rahman S5,3, Sabico S5,3, Al-Attas OS5,3, Alokail MS5,3, Al-Ajlan A6, Chrousos GP7.

  • 1Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. aldaghri2011@gmail.com.
  • 2Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia. aldaghri2011@gmail.com.
  • 3Prince Mutaib Chair for Biomarkers of Osteoporosis, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • 4Obesity, Endocrine and Metabolism Center, King Fahad Medical City, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, 11461, Saudi Arabia.
  • 5Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
  • 6Department of Clinical Lab Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 11433, Saudi Arabia.
  • 7First Department of Pediatrics, Athens University Medical School, 11527, Athens, Greece.

BACKGROUND:
The significance of vitamin D deficiency in the incidence of bone fractures in children has been under investigated. Here, we aimed to associate serum 25-hydroxyvitamin D levels and fractures in Saudi children.
MATERIALS AND METHODS:
This cross-sectional study was conducted in 1022 Saudi children without fracture history [476 boys (age 14.56 ± 1.81, BMI 22.38 ± 5.81) and 546 girls (age 13.57 ± 1.67, BMI 22.24 ± 4.94)] and 234 Saudi children with a history of fracture [148 boys (age 14.25 ± 1.39, BMI 22.66 ± 6.08) and 86 girls (age 13.76 ± 1.35, BMI 21.33 ± 1.35)]. Anthropometric and fasting serum biochemical data were collected. Serum 25-hydroxyvitamin D level was assessed using electrochemiluminescence.
RESULTS:
Mean circulating 25-hydroxyvitamin (25OH) D level in subjects with a history of fracture was significantly lower in both boys (p < 0.01) and girls (p < 0.01) than those without, however both groups had low mean 25(OH)D levels. Furthermore, age was positively associated with 25-hydroxyvitamin D in boys (p < 0.05) and negatively in girls (p < 0.05) with a history of fracture.
CONCLUSION:
In conclusion, vitamin D levels were significantly lower in children with a history of bone fractures in both boys and girls than those without such a history; even in the absence of fracture history, vitamin D status correction is warranted in the general Saudi pediatric population
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14 studies in both categories Falls-Fractures and Infant-Child:

22 studies in both categories Bone Health and Infant-Child:

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