Resveratrol and inflammatory bowel disease: the evidence so far – June 2018

Nutr Res Rev. 2018 Jun;31(1):85-97. doi: 10.1017/S095442241700021X
Nunes S1, Danesi F2, Del Rio D3, Silva P1.

VitaminDWiki

Overview Gut and vitamin D has the following summary

Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
Review in Nov 2013 found that Vitamin D helped
Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
All items in category gut and vitamin D 203 items

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio	Form	Speed	Duration
10	Injection ($$$) or Calcidiol or Calcitriol	D - Slow C -Fast	Long
10	Sun/UVB	Slow	Long
10	Topical (skin patch/cream, vagina)	Slow Fast nano	Normal
9	Nanoemulsion -mucosal perhaps activates VDR	Fast	Normal
9?	Inhaled (future)	Fast	Normal
8	Bio-D-Mulsion Forte	Normal	Normal
6	Water soluble (Bio-Tech)	Normal	Normal
4	Sublingual/spray (some goes into gut)	Fast	Normal
3	Coconut oil based	Slow	Normal
2	Food (salmon etc.)	Slow	Normal
2	Olive oil based (majority)	Slow	Normal

Bio Form Speed Duration
10 Injection ($$$)
or Calcidiol or Calcitriol D - Slow
C -Fast Long
10 Sun/UVB Slow Long
10 Topical
(skin patch/cream, vagina) Slow
Fast nano Normal
9 Nanoemulsion -mucosal
perhaps activates VDR Fast Normal
9? Inhaled (future) Fast Normal
8 Bio-D-Mulsion Forte Normal Normal
6 Water soluble (Bio-Tech) Normal Normal
4 Sublingual/spray
(some goes into gut) Fast Normal
3 Coconut oil based Slow Normal
2 Food (salmon etc.) Slow Normal
2 Olive oil based (majority) Slow Normal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Gut category listing contains the following

203 items in GUT category - see also Overview Gut and vitamin D,

Ulcerative Colitis and Vitamin D - many studies 12+
"celiac disease" OR CD 1830 items July 2019
IBS or IBD or IRRITABLE BOWEL in title of 41 VitaminDWiki pages as of Aug 2022
Gut-Friendly forms of vitamin D
- such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .

See also Microbiome category listing has 33 items along with related searches.

Download the PDF from VitaminDWiki

Despite the fact that inflammatory bowel disease (IBD) has still no recognised therapy, treatments which have proven at least mildly successful in improving IBD symptoms include anti-inflammatory drugs and monoclonal antibodies targeting pro-inflammatory cytokines. Resveratrol, a natural (poly)phenol found in grapes, red wine, grape juice and several species of berries, has been shown to prevent and ameliorate intestinal inflammation. Here, we discuss the role of resveratrol in the improvement of inflammatory disorders involving the intestinal mucosa. The present review covers three specific aspects of resveratrol in the framework of inflammation:

(i) its content in food;
(ii) its intestinal absorption and metabolism; and
(iii) its anti-inflammatory effects in the intestinal mucosa in vitro and in the very few in vivo studies present to date.

Actually, if several studies have shown that resveratrol may down-regulate mediators of intestinal immunity in rodent models, only two groups have performed intervention studies in human subjects using resveratrol as an agent to improve IBD conditions. The effects of resveratrol should be further investigated by conducting well-designed clinical trials, also taking into account different formulations for the delivery of the bioactive compound.