Emerging problems in the treatment of paediatric community-acquired pneumonia.
Expert Rev Respir Med. 2018 Jun 8. doi: 10.1080/17476348.2018.1486710. Epub ahead of print
Principi N1, Esposito S2.
1 Università degli Studi di Milano , Milano , Italy.
2 Pediatric Clinic, Department of Surgical and Biomedical Sciences , Università degli Studi di Perugia , Perugia , Italy.
- Hospital-acquired pneumonia treated by vitamin D if person was deficient – RCT Sept 2018
- Severe Pneumonia (CAP) results in death 2 times more often if very low vitamin D – July 2016
- Pneumonia patients 3 X more likely to die if low vitamin D – meta-analysis Sept 2017
- Pneumonia 2.6X more likely if low vitamin D – April 2013 seniors
- Pneumonia is less frequent in people with more than 35 ng of vitamin D – Nov 2013
has the following chart
Breathing category starts with the following
Breathing-related Overviews at VitaminDWiki:
Allergy Lung Cancer TB Asthma Influenza Colds and flu
Pneumonia Respiratory infections COPD Air Polution Smoking Cystic Fibrosis
Incidence of 22 health problems related to vitamin D have doubled in a decade
Have the health problems increased so slowly that,
like the slowly heated frog, we have not noticed?
Antibiotics are some of the cause of the increases - especially in children
- Antibiotics and Vitamin D are associated with many of the same diseases
- Antibiotic usage US map is very similar to obesity US map - June 2015
Community-acquired pneumonia (CAP) remains one of the most common reasons for paediatric morbidity and accounts for about 16% of all the deaths occurring in children less than 5 years of age. Areas covered: The main aim of this paper is to discuss the emerging problems for CAP treatment in paediatric age. Expert commentary: Official recommendations for therapeutic approaches to paediatric CAP, despite being not very recent, seem still to be the best solution to assure the highest probabilities of cure for children with this disease living in industrialized countries.
Amoxicillin remains the drug of choice and use of macrolides alone or in combination does not seem supported by solid evidence. Corticosteroids can be useful in CAP associated with bronco-obstruction, whereas their effectiveness in cases with a severe inflammatory response, although plausible, is not supported by data collected through randomized, placebo-controlled trials. Finally, for the administration of vitamin C and vitamin D, the available data are not adequate to draw firm conclusions regarding the real importance of supplementation. Further studies are needed to evaluate which modifications of presently available recommendations for paediatric CAP treatment can improve final prognosis of this still common disease.
PMID: 29883232 DOI: 10.1080/17476348.2018.1486710
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