Patients With Chronic Obstructive Pulmonary Disease May Stay Longer in Intensive Care Unit Due to the Low Serum Vitamin D Levels
Chest. 2015;148(4_MeetingAbstracts):689A. doi:10.1378/chest.2250791
Sakir Keskek, MD; Orhan Altinoz, MD
COPD groups in ICU
| Vitamin D level | Length of stay |
| 15 ng | 9.1 days |
| 40 ng | 6.7 days |
See also VitaminDWiki
- COPD fought by Vitamin D - many studies
having vitamin D might prevent COPD going to the ICU - COPD and Vitamin D, concise (46 page) review – Dec 2016
- COPD becoming suddenly worse is 30X more likely if low vitamin D – Dec 2014
Trauma and surgery category starts with the following
Trauma and Surgery category hasLarge dose Vitamin D before surgery was found to help by 35 studies
Vitamin D is needed before most surgeries – many studies and RCTs
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
Sepsis is both prevented and treated by Vitamin D - many studies
Thyroidectomy and Vitamin D - many studies
Orthopaedic surgeries need Vitamin D – many studies
Cancer - After diagnosis chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies
Glutamine and Omega-3 have also been proven to help several traumas/surgeries
Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
Trauma and Surgery is associated with 22 other VitaminDWiki categories
Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022
SESSION TITLE: COPD Posters I
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM
PURPOSE: Vitamin D is an immune modulator hormone which has major effects on nearly all cells of the immune system. The deficiency of vitamin D has been found to be associated with many diseases. Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory pulmonary disease asociated with significant mortality and morbidity. Immune system disorders may aggravate the COPD due to the increased morbidity. In this study we aimed to investigate the effect of serum vitamin d levels on COPD patients’duration of stay in intensive care unit (ICU).
METHODS: This retrospective study was performed in ICU of Adana Numune Training and Research Hospital. A total of 44 patients with COPD were included. Patients had diagnosed with COPD according to the GOLD 2011 report. The study and control groups included 23 and 21 patients with vitamin D deficiency or optimal vitamin D status, respectively. Serum 25(OH)D concentrations were used for vitamin D levels. Patients with different diseases in addition to the COPD were excluded. FEV1/FVC, FEV, serum creatinine levels and duration of stays in ICU were recorded and compared. MedCalc 15.2.2 (MedCalc Belgium) statistical software was used for statistical analysis.Chi-square is used to test the statistical significance of differences in frequencies. T test or Mann Whitney U tests were used for comparison of quantitative measurements between the two groups.
RESULTS: The groups were matched in terms of age and sex (p=0.65, 0.931, respectively). FEV1/FVC, FEV1 and serum creatinine levels were comparable in both groups (p=0.255, 0.393, 0.372, respectively). The levels of serum vitamin D were 14.7±4.0 and 39.7±11.1 in the study and control groups, respectively (p<0.001). Duration of stay in ICU was longer in COPD patients with low serum vitamin D levels (9.1±3.2 vs. 6.7±4.1, p=0.033).
CONCLUSIONS: Vitamin D deficiency may aggravate COPD and lead to stay longer in ICU.
CLINICAL IMPLICATIONS: Patients with COPD should be investigated for vitamin D deficiency. As an immune modulator vitamin D can protect COPD patients against co-morbidities such as infections. Therefore, supplementation of vitamin D can relieve the severity of disease and shorten the length of ICU stay.
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