Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT May 2018

Study supplemented those with low vitamin D with 20,000 IU weekly for just 4 months
   20,000 IU weekly = 2,900 IU daily
Many studies are recommending that everyone needs at least 4,000 IU daily for health

See also VitaminDWiki

• Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017
• Chronic Heart Failure improved with 4,000 IU daily for a year – RCT April 2016
• Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT Jan 2015
• 1700 IU vitamin D for a year provided no cardiovascular benefit (no surprise) – RCT Oct 2014
• Major heart problems avoided if have high vitamin D – 234,000 people Nov 2015
• Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017 Trial lasted for 12 months, not 4 months
• Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
  • Trial lasted for 12 months, not 4 months
• 3000 IU reduced hypertension for the vitamin D insufficient – RCT Aug 2012
  • Trial lasted for 5 months
• Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017

Cardiovascular category starts with the following

• Overview Cardiovascular and vitamin D
• Hypertension and vitamin D
• Overview Metabolic Syndrome and vitamin D
• Overview Stroke and vitamin D
• Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
• Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
• Heart attack ICU costs cut in half by Vitamin D – Oct 2018

Meta-analyses

• Heart Failure and Vitamin D meta-analyses - 2016, 2019
• Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
• Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018

Omega-3 Helps

• Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
• Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017

A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues

• Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
• Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016

Cholesterol, Statins

• Cholesterol is needed to produce both Vitamin D and Cortisol
• Overview Cholesterol and vitamin D
• Statins and vitamin D statins often reduce levels of vitamin D
• Statin side-effects are reduced by Vitamin D – US patent Application – April 2019

Overview Diabetes and vitamin D contains the following summary

• Diabetes is 5X more frequent far from the equator
• Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
• Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
• Sedentary people get less sun / Vitamin D
• Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
• Elderly get 4X less vitamin D from the same amount of sun
      Elderly also spend less time outdoors and have more clothes on
• All items in category Diabetes and Vitamin D 463 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

• Appears that >2,000 IU will Prevent
• Appears that >4,000 IU will Treat , but not cure
• Appears that Calcium and Magnesium are needed for both Prevention and Treatment
  • which are just some of the vitamin D cofactors

Number of articles in both categories of Diabetes and:

• Dark Skin 22;   Intervention 50;   Meta-analysis 30;   Obesity 26;  Pregnancy 39;   T1 (child) 36;  Omega-3 10;  Vitamin D Receptor 20;  Genetics 11;  Magnesium 19    Click here to see details

Diabetes category starts with the following

see also Overview Diabetes and vitamin D  Overview Metabolic Syndrome and vitamin D

T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 336 items as of Jan 2018
Search VitaminDWiki for Peripheral Neuropathy 238 items April 2018

Hypertension category listing contains the following

see also
Overview Hypertension and vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
Some interesting Hypertension studies

• COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
• Drug-resistant hypertension 3.5 X more likely if low vitamin D – March 2020
• High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
• Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
• Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
• Hypertension risk decreased 10X by increasing vitamin D levels to more than 40 ng – Nov 2017
• Off Topic – Hypertension in 42 percent of adults (new definition: 130 mm Hg) – Feb 2018
  • Men aged 40-59 59%, age >60 75%: National Health and Nutrition Examination Survey, 2017–2018