Vitamin D supplementation does not improve CVD risk factors in vitamin D insufficient subjects.
Endocr Connect. 2018 May 15. pii: EC-18-0144. doi: 10.1530/EC-18-0144. [Epub ahead of print]
Kubiak JM1, Thorsby PM2, Kamycheva E3, Jorde R4.
Study supplemented those with low vitamin D with 20,000 IU weekly for just 4 months
20,000 IU weekly = 2,900 IU daily
Many studies are recommending that everyone needs at least 4,000 IU daily for health
See also VitaminDWiki
- Hypertension not controlled by 26 ng of Vitamin D (50,000 IU bi-weekly A-A) – RCT Nov 2017
- Chronic Heart Failure improved with 4,000 IU daily for a year – RCT April 2016
- Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT Jan 2015
- 1700 IU vitamin D for a year provided no cardiovascular benefit (no surprise) – RCT Oct 2014
- Major heart problems avoided if have high vitamin D – 234,000 people Nov 2015
- Blood pressure reduced by monthly 100,000 IU of vitamin D in those who were deficient – RCT Oct 2017 Trial lasted for 12 months, not 4 months
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Trial lasted for 12 months, not 4 months
- 3000 IU reduced hypertension for the vitamin D insufficient – RCT Aug 2012
- Trial lasted for 5 months
- Diabetes treated if given enough vitamin D (example: 50,000 IU weekly) – review of RCT - Jan 2017
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
447 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
22 ; Intervention 48 ; Meta-analysis 28 ; Obesity 26 ; Pregnancy 39 ; T1 (child) 33 ; Omega-3 10 ; Vitamin D Receptor 18 ; Genetics 9 ; Magnesium 18 Click here to see details
Diabetes category starts with the following
447 items In Diabetes category see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has162 items along with related searches T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 336 items as of Jan 2018
Search VitaminDWiki for Peripheral Neuropathy 238 items April 2018
Hypertension category listing contains the following
133 items in the category HYPERTENSION see also
Overview Hypertension and vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
160% increase per decade (women, age adjusted)Download the PDF from VitaminDWiki
OBJECTIVE:
Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D insufficient subjects.DESIGN: Double-blinded randomized controlled trial.
METHODS: A four months interventional study with high dose vitamin D (100 000 IU loading dose, followed by 20 000 IU/week) or placebo with measurements of:
- blood pressure,
- lipids (total-, LDL- and HDL-cholesterol, triglycerides, apolipoproteins A1 and B ), and
- glucose metabolism parameters
(blood glucose,HbA1c, sRAGE (minor improvement), insulin, C-peptide, and HOMA-IR).
RESULTS:
422 subjects with mean serum 25(OH)D level 34 nmol/L were included, with 411 subjects completing the study. Serum 25(OH)D levels increased with 56 nmol/L and decreased with 4 nmol/L in the vitamin D and placebo group, respectively. We found no statistically significant differences between the two groups in any of the measured CVD risk factors, except for a minor increase in sRAGE in the vitamin D group.
Stratified analyses of subjects with low baseline serum 25(OH)D levels alone, or combined with blood pressure, lipid and HOMA-IR values above the median for the cohort, did not skew the results in favour of vitamin D supplementation.CONCLUSION: Supplementation with vitamin D in subjects with baseline vitamin D insufficiency does not improve CVD risk factors profile.
PMID: 29764903 DOI: 10.1530/EC-18-0144
Cardiovascular risk markers not helped by 20,000 IU of vitamin D weekly – RCT May 2018
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