Some drugs change potency when Vitamin D is increased (increase in a hormone)

Drug dosages were established for people with < 30 ng of Vitamin D

1) Increased D ==> Increases drug potency ==>sometimes increases risk of death
2) Increased D ==> Decreases drug potency ==> sometimes increases risk of death


VitaminDWiki – Interactions with Vitamin D contains

Interactions with Vitamin D has 124 items

Various drugs decrease Vitamin D
Drug interactions with Vitamin D - many studies - Feb 2024
Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
Medications that appear to lower Vitamin D – Aug 2021
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Proton pump inhibitors decrease Vitamin D and Magnesium – Dec 2018
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
Antibiotics and Vitamin D are associated with many of the same diseases
More colas lower vitamin D by 3 ng– July 2014
A few Drugs increase Vitamin D
Contraceptives,   Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Plastics, BPA, PCB and Vitamin D deficiency
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D production - many studies
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
Smoking   Coffee
Cooked dried beans or peas


Increasing vitamin D substantially DECREASES the potency of various medications

  • atorvastatin, thiazide diuretic,

Increased drug ==> Decreased Vitamin D: happens far more frequently than 1) or 2) above


Note: Most of the mortality increases due to high vitamin D have occurred among the elderly
   elderly take an average of 6 prescription drugs
     the doses were established for people who had low levels of vitamin D


Speculation: Increased Vitamin D increases the interaction between two drugs which a person is taking

That is:
Drug A + Drug B + LOW level of Vitamin D ==> no problem
But, Drug A + Drug B + HIGH level of Vitamin D ==> a problem

13907 visitors, last modified 22 Jul, 2023,
Printer Friendly Follow this page for updates