Sleep disturbances and serum vitamin D levels in children with autism spectrum disorder
Int J Clin Exp Med 2016;9(7):14691-14697 www.iicem.com /ISSN:1940-5901/IJCEM0028304
Received March 15, 2016; Accepted June 8, 2016; Epub July 15, 2016; Published July 30, 2016
Serhat Guler1, Gozde Yesil2, Mine Ozdil3, Bari§ Ekici4, Hasan Onal5
1Department of Pediatric Neurology, Edirne State Hospital Edirne, Turkey; 2Department of Medical Genetics, Bezmialem Vakif University Medical School, Istanbul, Turkey; 3Department of Pediatrics, Istanbul University, Cerrahpasa Medical School, Istanbul, Turkey; 4Department of Pediatric Neurology, LIV Hospital, Istanbul, Turkey; 5Department of Pediatric Endocrinologic and Metabolic Diseases, Istanbul, Kanuni Sultan Suleyman Education and Research Hospital, Turkey
Vitamin D improved sleep of both Autistics and Controls
The study supplmented with Vitamin D2 for 3 months
Vitamin D2 given to BOTH Autistics and Controls who had <30 nanograms
Insufficient group got 5,000 IU daily
Deficient group got 50,000 IU weekly ( 7,000 IU average)
- "The 25(OH)D levels did not improve in 11.7% of ASD patients and 6.7% of controls after the treatment"
Comment: Using D3 and higher doses would have resulted in even better sleep
See also VitaminDWiki
Sleep category listing has- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015
- Sleep longer if have more vitamin D – many studies
- Many sleep disorders cured with vitamin D levels of 60 to 80 nanograms – May 2012
Note the study on this page just got levels to 30 nanograms (far less)
- Overview Autism and vitamin D
- Autism is associated with low vitamin D – meta-analysis Oct 2015
- Autism and Vitamin D massive review – latitude, season, migration, VitD levels and intervention – April 2016
The items in both Autism and Sleep categories are listed here:
Download the PDF from VitaminDWiki
Sleep problems are among the most prevalent comorbidities experienced by children with Autism Spectrum Disorder (ASD). There is a clinical and physiological basis for a link between 25(OH)D levels and sleep disorders. In this study we aimed to investigate the frequency of sleep disorders in ASD patients and its association with 25(OH) D levels, and whether or not these frequencies changed after 25(OH)D treatment. This prospective study included 60 consecutive patients diagnosed with ASD and matched healthy controls between the ages of 4 and 10. Patients then underwent 25(OH)D replacement therapy according to their deficiency levels. Pre- and post-therapy values were compared. Sleep disturbance was detected in 78.3% of ASD patients (n = 60) and 33.3% of the control group (n = 60). When we compared the pretreatment scores of sleep disturbance between ASD and control groups (n = 60), there were significant differences in bedtime resistance, sleep anxiety, parasomnias, daytime sleepiness, sleep duration, sleep-onset delay, night wakings subscales, and total scale score (p < 0.05); however there were no significant differences with respect to the sleep-disordered breathing subscales (p > 0.05). In ASD patients, there was a significant negative correlation between serum 25(OH)D levels and the night wakings subscale (r = -0.301, p = 0.019). In control patients, there was a significant negative correlation between serum 25(OH)D levels and daytime sleepiness subscales (r = -0.269, p = 0.038). The results indicate that it may be suitable to use 25(OH)D replacement therapy in ASD patients and healthy individuals with sleep disturbances.
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