Nanoemulsion Vitamin D is faster and better - many studies

Bought and tested several nanoemulsions
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Note: The following studies compare oral nano vs oil-based vitamin D
I do not recall a study of topical, sublingual or buccal Vitamin D
   that skips the stomach, intestine, liver, and kidneys

Vitamin D nanoemulsions 3.9X more bioavailable than Vitamin D micelles – Feb 2018

The Efficacy of Nanoemulsion-Based Delivery to Improve Vitamin D Absorption: Comparison of In Vitro and In Vivo Studies
Comparative Study Mol Nutr Food Res 2018 Feb;62(4). doi: 10.1002/mnfr.201700836
Alagu Selvi Kadappan 1, Chi Guo 1 2, Cansu E Gumus 3 4, Amy Bessey 1, Richard J Wood 1, David J McClements 3, Zhenhua Liu 1 5

Nanoemulsions result in more uniform response than other forms

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Scope: Vitamin D (VD) is a fat-soluble vitamin that has a wide range of skeletal and non-skeletal functions. Although it can be synthesized through sun exposure and obtained from fortified foods, VD inadequacy is epidemic worldwide. Therefore innovative strategies are necessary for improving VD status. The present study examined VD absorption via nanoscale delivery systems.

Methods and results: We examine the physical characteristics and in vitro bioaccessibility of cholecalciferol (VD3 ) in nanoemulsion using a simulated gastrointestinal tract system. To evaluate the in vivo bioavailability, we orally administer three groups of mice with VD3 nanoemulsion, VD3 coarse emulsion, or vehicle nanoemulsion without VD3 , and the serum 25(OH)D3 is measured using radioactive immunoassay. The nanoemulsion-based delivery system increases the in vitro bioaccessibility by 3.94-folds (p < 0.05), as indicated by the concentration of vitamin D3 in micelles. Our animal study shows that, when compared to the vehicle group, the coarse emulsion numerically increases the serum 25(OH)D3 by 36%, whereas the nanoemulsion statistically significantly increases the serum 25(OH)D3 by 73% (p < 0.01).

Conclusion: Our findings indicate that a nanoemulsion-based delivery system is a promising approach to improve VD bioavailability, and further studies are warranted to determine its efficacy in humans.
 Download the SciHub PDF from VitaminDWiki

Study was cited 74 times as of Sept 2024
Google Scholar

Nanoemulsion vitamin D 40% more bio-available than fat-soluble - RCT Jan 2023

An open-label, randomized, crossover study to evaluate the bioavailability of nanoemulsion versus conventional fat-soluble formulation of cholecalciferol in healthy participants
Journal of Orthopaedics Volume 35, January 2023, Pages 64-68 https://doi.org/10.1016/j.jor.2022.10.017
Raman Kumar Marwaha a, Manish Verma b 1, Ajit Walekar c, Rakesh Sonawane b 2, Chirag Trivedi c

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Background
Nanoemulsion preparations of cholecalciferol available in the market claim to have better bioavailability than the conventional fat-soluble cholecalciferol. However, limited data are available in humans for such preparations. We, therefore, compared the relative bioavailability of two formulations of 60,000 IU cholecalciferol (nanoemulsion oral solution, water-miscible vitamin D3 [test] vs soft gelatin capsules [reference]) in healthy adult participants.

Methods
In this randomized, open-label, two-sequence, single-dose, two-way crossover study (CTRI/2018/05/013839), Indian participants aged 18–45 years received single dose of nanoemulsion and capsule formulations, under fasting conditions. Blood samples collected over 120 h were assessed to determine cholecalciferol concentrations. Pharmacokinetic parameters (area under the concentration-time curve up to 120 h [AUC0–120h], maximum observed drug concentration [Cmax], time to reach maximum drug concentration [Tmax], terminal half-life [T½el], and terminal elimination rate constant Kel) were estimated using baseline corrected data and analyzed using analysis of variance.

Results
Among the 24 eligible participants, the relative bioavailability of nanoemulsion was significantly higher than the capsules by 36% (p = 0.0001) based on AUC0–120h. Similarly, Cmax of the nanoemulsion was significantly higher by 43% (p = 0.0001) than that of the capsules. The intra-participant variability for AUC0–120h and Cmax were 23.22% and 26.51%, respectively. The Tmax, T½el, and Kel were comparable for both the formulations. No adverse effects were noted with either of the two formulations.

Conclusions
Nanoemulsion oral solution of cholecalciferol showed a greater bioavailability compared with soft gelatin capsules, under fasting conditions, in healthy human participants.
 Download the PDF from VitaminDWiki

Nanoemulsion 36% more bioavailable than fat soluble forms (single 60,000 IU dose) - Dec 2019

Bioavailability of nanoemulsion formulations vs conventional fat soluble preparations of cholecalciferol (D3) – An overview
J. of Clinical Orthopaedics & Trauma Nov–Dec 2019, pg 1094-1096 https://doi.org/10.1016/j.jcot.2019.07.014
Raman Kumar Marwaha a, Aashima Dabas b

Vitamin D deficiency is recognized as a pandemic affecting all ages and strata of population. The endogenous cutaneous synthesis of vitamin D is insufficient to maintain normal body requirement which necessitates the need for vitamin D supplementation or food-fortification. Conventional fat-soluble preparations of vitamin D have been traditionally used for prevention and therapeutic purposes. Recent advances in technology have enabled delivery of vitamin D through nanoemulsion formulations which ensure higher absorption and drug delivery. The following review briefly discusses the issues of bioavailability of nanoemulsion preparation of vitamin D vis-a-vis conventional fat soluble preparations.
 Download the PDF from VitaminDWiki

Clipped from PDF
"...a single oral dose of 60,000 IU in healthy participants. The results showed that relative bioavailability in terms of serum levels of cholecalciferol following supplementation with nano preparation of vitamin D3 was significantly higher than fat-soluble D3 by 36%(P ¼ 0.001) based on AUC 0-120. "
Clipped from PDF
The nanoemulsions are considered superior to conventional vitamin D preparations for the following reasons:

  • a) It has greater therapeutic role in patients with malabsorption syndromes due to
    • Inflammatory bowel disease,
    • Celiac disease,
    • Short bowel syndrome,
    • Hepatobiliary disorders,
    • Pancreatic insufficiency and
    • Bariatric surgery who suffer from a deficiency of essential fatty acids and fat-soluble vitamins including vitamin D,
  • b) Better compliance as it can be taken directly or with water/juice etc.
  • c) Vitamin D nanoemulsions may also have also greater hepato-protective effect against high-fat diet-induced liver injury as observed in rats compared to conventional oral vitamin D preparations.

Current Update on Nanoemulsion A Review - Jan 2021

CoVID19 VitD and Nanotechnology Review EJBPS ; Jan 2020 BioTech

Nanoemulsions for health, food, and cosmetics

Advances in edible nanoemulsions - Digestion, bioavailability, and potential toxicity

Nanoemulsions SciHub 2020

Nanoemulsions - The rising star of antiviral therapeutics

Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods

19+ VitaminDWiki pages with NANOEMULSION or EMULSION etc. in the title

This list is automatically updated

Items found: 21
Title Modified
Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT May 2024 01 Jun, 2024
Vitamin D: liposomal and nanoemulsion forms - Chat-GPT Dec 2023 30 Dec, 2023
Nanoemulsion Vitamin D is faster and better - many studies 06 Oct, 2023
Fast responses to Vitamin D – loading dose, nanoemulsion and Calcifediol – April 2023 15 Apr, 2023
Nanoemulsion Vitamin D faster and better (paywall) – RCT Dec 2021 02 Dec, 2021
COVID-19 defeated 3x faster by 420,000 IU Vitamin D nanoemulsion – RCT Nov 12, 2020 21 Sep, 2021
Nanoemulsion Vitamin D may be a substantially better form 02 Jun, 2021
COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021 22 May, 2021
Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020 03 Aug, 2020
Vitamin D nanoemulsion, with comments on COVID-19 – June 2, 2020 04 Jun, 2020
Nanoemulsion vitamin D is again found to be the best liquid form (for rats in this case) – June 2019 20 Dec, 2019
Bioavailability of nanoemulsion formulations of Vitamin D3 – Nov 2019 20 Dec, 2019
Vitamin D nanoemulsion etc. for fortification, pills, injections, topical and cancer – July 2019 18 Jul, 2019
Vitamin D Emulsion update - March 2019 28 Mar, 2019
Vitamin D Emulsions - nano 2X better than coarse – Dec 2017 04 Mar, 2019
Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019 05 Jan, 2019
Advances in Vitamin D emulsions, nanoparticles, etc. – Jan 2019 30 Dec, 2018
Colitis treated by activated vitamin D getting into the colon via emulsion (mice) – July 2018 24 Jul, 2018
Lung cancer and inhaled emulsions (wonder about inhaled Vitamin D) – 2018 17 Jun, 2018
Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017 19 Apr, 2018
Nanoemulsions of vitamin D help reduce asthma markers in mice– Dec 2013 12 Dec, 2013

See also in VitaminDWiki

50,000 IU powder in capsule
Example Biotech Pharmacal		Nanoemulsion
Example micro D3
Average Cost
per day for 10,000 IU		4 cents8 cents
IU per serving 50,000 IU = capsule2,000 IU = drop
Servings if want average
of 10,000 IU/day		1 capsule
per 5 days		25 drops = 1 /4 teaspoon
per 5 days
Shelf life 1 year?6 months?
Add to food/drinkYes (powder) possiblly
Apply to skinNoYes
Swish in mouth
for fast response		Yes if put powder in saliva
or swish vitamin D water		Yes
Gut-friendlyperhapsprobably
Availability to cell
- better than bio-availability		standardperhaps 2X more
- due to small size
or activation of Vitamin D Receptor
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