Dengue virus might be fought by Vitamin D (again)– Aug 2021

Chapter Ten - Immunomodulatory effect of vitamin D on immune response to dengue virus infection

Vitamins and Hormones. Volume 117, 2021, Pages 239-252, https://doi.org/10.1016/bs.vh.2021.06.001
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VitaminDWiki

Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Bird Flu, Epstein, Hepatitis, RSV, etc.) – March 2011
SARS, SARS-COV2, and Dengue are enveloped

Each year, an estimated 400 million people are infected with dengue virus, 100 million become ill with dengue, and 21,000 deaths are attributed to dengue - CDC

VitaminDWiki pages containing DENGUE in title

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Items found: 13

Title		Modified
Dengue Fever decimated by Vitamin D - many studies		20 Oct, 2023
Dengue virus: 3X increase in hospitalization and deaths in Vietnam - July 2022		19 Jul, 2022
Dengue virus might be fought by Vitamin D (again)– Aug 2021		24 Aug, 2021
Dengue viral production decreased 1000X if activate Vitamin D Receptor (in lab) – July 2020		04 Jul, 2020
Dengue virus 2X to 4X more likely if vitamin D receptor gene problems		08 May, 2020
Dengue virus prevented by a small amount of Vitamin D – RCT Nov 2019		26 Nov, 2019
Dengue fever - 8X higher risk for getting worse if low vitamin D – Sept 2017		15 Sep, 2017
Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015		11 Jun, 2016
Dengue virus infection treated by (active) Vitamin D in the lab – April 2012		20 May, 2016
Dengue, Vitamin D and microRNAs – May 2016		20 May, 2016
Dengue virus avoids the INNATE immune system – Dec 2012		02 May, 2016
Dengue Fever associated with poor vitamin D receptor – July 2002		01 May, 2016
Dengue Antibodies appear to enhance Zika Infection – April 2016		01 May, 2016

COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023

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13461	Obesity, Hypovitaminosis D, and COVID-19 – April 2022	6094	24 Nov, 2024 20:17	admin	Deficiency of Vitamin D Obesity Virus
13008	Bird flu possible pandemic (Vitamin D can prevent it)- many studies	153825	22 Nov, 2024 21:35	admin	Virus
14480	Fasting may reduce inflammation and long-COVID - June 2023	6666	21 Nov, 2024 13:30	admin	Inflammation Virus
15671	Measles and low Vitamin D, Vitamin A	128	19 Nov, 2024 16:59	admin	Vitamin D and Vitamin A Virus AI
15509	Vitamin D or bright light treat COVID, TB, SAD, etc.	1684	18 Nov, 2024 10:36	admin	Noontime sun and D Tuberculosis Depression Virus

Dengue, an acute febrile illness which in some cases requires hospitalization and occasionally a fatal disease, caused by dengue virus is a potential threat to the public health systems throughout the world. Approved antivirals are not available for treating dengue. Immunomodulators, that can reduce inflammation which if not treated properly results in vascular leakage, are being attempted as therapeutics against severe dengue. Vitamin D, an immunomodulatory hormone, with both antiviral and immunomodulatory effects, is an appropriate choice for investigation as a potential drug against dengue.
Investigations of vitamin D levels by many studies have suggested vitamin D levels as a potential marker for predicting severe dengue. In-vitro studies have shown that 1, 25 dihydroxy vitamin D3 (1,25(OH)2D3), active form of vitamin D, can reduce the expression of dengue virus entry receptors, restrict the viral replication and can modulate the expression of inflammatory cytokines in dengue virus infected cells.
The results from in-vitro studies also have cautioned that insufficient levels of vitamin D supplementation might increase the virus replication. Available evidence suggests vitamin D based therapeutics against dengue and provides ray of light for treating dengue patients but, the available evidence needs to be supported by beneficial outcomes in clinical trials.

Table of Contents
1. Introduction
2. Synthesis of vitamin D and its mode of action
3. Circulating levels of vitamin D in DENV infected subjects
4. Immunomodulatory effects of vitamin D on the immune response to DENV
5. Vitamin D, a double-edged sword in dengue disease (low D ==> increases DENV)
6. Vitamin D receptor agonists: A novel therapeutic strategy against DENV
7. Vitamin D receptor gene variants and dengue
8. Clinical trials investigating the effects of vitamin D supplementation in reducing severe dengue
9. Conclusions