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Vitamin D3 half-life about 10 days with pancreatitis inflammation – 2011

Variations in serum 25-hydroxyvitamin D during acute pancreatitis: an exploratory longitudinal study.

Endocr Res. 2011;36(4):135-41.
Bang UC, Novovic S, Andersen AM, Fenger M, Hansen MB, Jensen JE.
Department of Endocrinology, Hvidovre Hospital, Copenhagen, Denmark. ulrichbangbang at gmail.com

OBJECTIVES: We tested the hypothesis that 25-hydroxyvitamin D3 (25OHD) changes during acute inflammation in humans.

METHODS: Patients with first episode of acute pancreatitis were included. Blood samples were acquired on admission and on days 1, 2, and 14.

RESULTS:
In total, 73 patients (35 males, median age 59) entered the study. On admission, the distribution of 25-OHD levels was as follows: severely deficient (<13 nmol/L) 23%; deficient (13-25 nmol/L) 20%; insufficient (26-50 nmol/L) 40%; and normal (<50 nmol/L) 17%. There was a significant fall and linear trend in 25OHD, albumin, and hemoglobin from day 0 to day 2.

From day 0 to day 2 the drop in 25OHD was 3.1 nmol/L (95% CI 0.59-5.63).

The changes from day 0 to day 2 in 25OHD were associated with changes in C-reactive protein (p = 0.02) but not with leukocyte or monocyte count.

CONCLUSIONS:
The 25OHD levels dropped during the first 2 days of acute pancreatitis beyond what was expected based on 25OHD half-life. This study supports our hypothesis that an acute inflammatory condition utilizes 25OHD, but other mechanisms could interfere.

PMID: 21973232
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No indication in abstract of average vitamin D level, so we have had to estimate the half-life.
We can only wonder how much the vitamin D level dropped before entering the hospital.

See also VitaminDWiki

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