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Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020

Vitamin D supplementation and the outcomes of critically ill adult patients: a systematic review and meta-analysis of randomized controlled trials

Scientific Reports volume 10, Article number: 14261 (2020)
Shao-Huan Lan, Chih-Cheng Lai, Shen-Peng Chang, Li-Chin Lu, Shun-Hsing Hung & Wei-Ting

VitaminDWiki

Would expect much better results if had one or more of the following

  1. Start Loading dose BEFORE ICU
  2. Use a Gut-Friendly Vitamin D
    • Often people in the ICU have poor digestion, and will not absorb the Vitamin D very well
  3. Use a larger dose for those are obese
  4. Also use Resveratrol or other supplements that increase Vitamin D getting to cells
  5. Also use Omega-3 - which had been found to help in the ICU

Items in both categories Meta-analysis and Loading Dose:

Loading Dose of Vitamin D category has the following

152 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Injection category listing has 53 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses

The TOP articles in Loading Dose of Vitamin D are listed here:

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This meta-analysis assessed the association between vitamin D supplementation and the outcomes of critically ill adult patients. A literature search was conducted using the PubMed, Web of Science, EBSCO, Cochrane Library, Ovid MEDLINE, and Embase databases until March 21, 2020. We only included randomized controlled trials (RCTs) comparing the efficacy of vitamin D supplementation with placebo in critically ill adult patients. The primary outcome was their 28-day mortality. Overall, 9 RCTs with 1867 patients were included. In the pooled analysis of the 9 RCTs, no significant difference was observed in 28-day mortality between the vitamin D supplementation and placebo groups (20.4% vs 21.7%, OR, 0.73; 95% CI, 0.46–1.15; I2 = 51%). This result did not change as per the method of vitamin D supplementation (enteral route only: 19.9% vs 18.2%, OR, 1.19; 95% CI, 0.88–1.57; I2 = 10%; intramuscular or intravenous injection route: 25.6% vs 40.8%, OR, 0.48; 95% CI, 0.21–1.06; I2 = 19%) or daily dose (high dose: 20.9% vs 19.8%, OR, 0.83; 95% CI, 0.51–1.36; I2 = 53%; low dose: 15.6% vs 21.3%, OR, 0.74; 95% CI, 0.32–1.68; I2 = 0%). No significant difference was observed between the vitamin D supplementation and placebo groups regarding the length of ICU stay (standard mean difference [SMD], − 0.30; 95% CI, − 0.61 to 0.01; I2 = 60%), length of hospital stay (SMD, − 0.17; 95% CI, − 041 to 0.08; I2 = 65%), and duration of mechanical ventilation (SMD, − 0.41; 95% CI, − 081 to 0.00; I2 = 72%). In conclusion, this meta-analysis suggested that the administration of vitamin D did not provide additional advantages over placebo for critically ill patients. However, additional studies are needed to confirm our findings.


Created by admin. Last Modification: Wednesday September 2, 2020 15:32:37 GMT-0000 by admin. (Version 7)

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14256 ICU days.jpg admin 02 Sep, 2020 14:55 39.83 Kb 72
14254 Criticall Ill meta-analysis.pdf PDF 2020 admin 02 Sep, 2020 14:52 1.74 Mb 27
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