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How Vitamin D helps the body fight viral infections such as COVID-19 – Sept 2024


Role of vitamin D in COVID-19 and other viral infections

World J Virol. Sep 25, 2024; 13(3):  doi: 10.5501/wjv.v13.i3.95349
Muhammet Mesut Nezir Engin,
Öner Özdemir onerozdemir at sakarya.edu.tr

Table of Contents
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Vitamin D is a steroid hormone that is naturally produced in the body or obtained through dietary sources, primarily under the influence of UVB radiation. This essential nutrient has a vital role in numerous physiological processes, encompassing immune function, cell growth, differentiation, insulin regulation, and cardiovascular well-being, along with its pivotal role in sustaining the delicate equilibrium of calcium and phosphate concentrations in the body.
Moreover, vitamin D reinforces mucosal defense and bolsters the immune system through immunomodulation, making it a critical component of overall health.
Numerous studies have unveiled the profound connection between vitamin D and the predisposition to respiratory tract infections, including well-known viruses such as influenza and the novel severe acute respiratory syndrome coronavirus 2.
Vitamin D deficiency has been consistently linked to increased severity of coronavirus disease 2019 (COVID-19) and a heightened risk of mortality among afflicted individuals.
Retrospective observational studies have further substantiated these findings, indicating that levels of vitamin D are linked with both the occurrence and severity of COVID-19 cases.
Vitamin D has its influence on viral infections through a multitude of mechanisms, such as promoting the release of antimicrobial peptides and fine-tuning the responses of the immune system.
Additionally, vitamin D is intertwined with the intricate network of the renin–angiotensin system, suggesting a potential impact on the development of complications related to COVID-19.
While further clinical trials and extensive research are warranted, the existing body of evidence strongly hints at the possible use of vitamin D as a valuable tool in the prophylaxis and management of COVID-19 and other viral infectious diseases.

Core Tip: While further clinical trials and extensive research are warranted, the existing body of evidence strongly hints at the possible use of vitamin D as a valuable tool in the prophylaxis and management of coronavirus disease 2019 and other viral infectious disease.

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VitaminDWiki – COVID-19 treated by Vitamin D - studies, reports, videos

As of March 31, 2024, the VitaminDWiki COVID page had:  trial results,   meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
5 most-recently changed Virus entries

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Some COVID and Vitamin D studies

Some other Virus and Vitamin D studies


VitaminDWiki – 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D includes

CDC: Confirms Low Vitamin D
VitaminDWiki and other
Cancer VitaminDWiki 7X
Chronic kidney diseaseVitaminDWiki
COPD & other lung problemsPneumonia - VDW
Lung Death 4X
Down Syndrome VitaminDWiki - deficiency
Heart conditionsVitaminDWiki
Immunocompromised stateVitamin D helps organ transplant - many studies
Cancer - After diagnosis
Obesity Overview Obesity and Vitamin D
PregnancyOverview Pregnancy and vitamin D
Sickle cell diseaseOverview Sickle Cell and Vitamin D
Smoking Smoking reduces vitamin D - many studies
Diabetes T2VitaminDWiki
CDC: Might be factors
Asthma Overview Asthma and Vitamin D
Cerebrovascular disease Cardiovascular   Stroke
Cystic fibrosisCystic Fibrosis
Hypertension VitaminDWiki
ACE inhibitors VitaminDWiki 4X
Neurologic conditions,
such as dementia
Overview Alzheimer's-Cognition and Vitamin D
Liver diseaseOverview Liver and vitamin D
Pulmonary fibrosisPulmonary Fibrosis
Thalassemia VitaminDWiki - deficiency
Diabetes T1 T1 Diabetes
CDC: Still fails to mention
AgeOverview Seniors and Vitamin D
Nursing HomesNursing homes and Vitamin D - many studies
Prisons Prisoners have low Vitamin D - many studies
Dark SkinVitaminDWiki
Vertebral Fracture VitaminDWiki
Shift workVitaminDWiki 2X
Mood disorders Note:
Low D ==> depression
1.5X increase in COVID-19 death
Concealing clothingVitaminDWiki 3.5X
Schizophrenia 3X mortalityVitaminDWiki Low D since birth

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Sometimes A health problem will cause a Vitamin D deficiency
Sometimes A Vitamin D deficiency will cause another health problem
AlwaysStop a vitamin D deficiency to avoid getting additional health problems

Attached files

ID Name Comment Uploaded Size Downloads
21808 viral Infections table.webp admin 26 Sep, 2024 119.87 Kb 75
21807 Viral infection ToC.webp admin 26 Sep, 2024 33.69 Kb 76
21806 Role of vitamin D in COVID-19 and other viral infections_CompressPdf.pdf admin 26 Sep, 2024 444.93 Kb 21