Loading...
 
Toggle Health Problems and D

Knee osteoarthritis treated by Vitamin D - many studies

Knee Osteoarthritis 1.7 more likely if low Vitamin D - Jan 2024

Relationship between serum vitamin D levels and the prevalence of knee osteoarthritis: A retrospective study on 3424 subjects
Technol Health Care. 2024 Jan 4. doi: 10.3233/THC-230802 PDF Price: EUR 27.50
Seçkin Özgür Tekeli 1, Özkan Köse 1 2, Dilek Yapar 3, Feyza Yağmur Tekeli 4, Mehmet Melih Asoğlu 1, Emre Mücahit Kartal 1

Background: The extent of the association between vitamin D deficiency and knee osteoarthritis remains inadequately understood.

Objective: This study aimed to elucidate the relationship between vitamin D levels and knee osteoarthritis through a cross-sectional analysis.

Methods: This retrospective study involved an analysis of knee radiographs and serum 25-hydroxyvitamin D3 (25-(OH) vitamin D3) levels in a cohort of 3424 individuals (2901 women and 523 men). Knee osteoarthritis severity was evaluated using the Kellgren-Lawrence radiological scoring system.

Results: Of the participants, 49.2% (n= 1,683) were diagnosed with knee osteoarthritis. Among these patients, the levels of adjusted 25-(OH) vitamin D3 were significantly lower (p< 0.001). Regression analysis revealed a significant association between vitamin D deficiency and knee osteoarthritis, with an adjusted odds ratio (OR) of 1.7 (95% CI: 1.5-2.0; p< 0.001). Notably, a stronger association was observed between vitamin D deficiency and knee osteoarthritis in women under 65 compared to those aged 65 and above.

Conclusions: The findings of this study indicate a higher prevalence of vitamin D deficiency in patients with knee osteoarthritis. Maintaining adequate serum 25-(OH) vitamin D3 levels may prevent knee osteoarthritis, especially in women below 65.

Both Vitamin D and Magnesium appear to be needed if have Knee Osteoarthritis - Oct 2023

__Investigation of the relationship between magnesium level and vitamin D, bone mineral density, and chronic diseases in patients with knee osteoarthritis
Magnes Res. 2023 Jun 1;36(2):40-48. doi: 10.1684/mrh.2023.0515 PDF behind paywall
Ebru Yilmaz 1, Sena Ünver 2

The maintenance of various physiological cellular processes requires mineral magnesium (Mg). The purpose of the study was to determine a possible association between Mg level and vitamin D levels, bone mineral density (BMD), chronic diseases, and radiographic stage in individuals with knee osteoarthritis (OA). The study included 98 individuals (62 female and 36 male) who had been diagnosed with at least grade 1 knee OA. Age, sex, smoking, body mass index (BMI), family history of osteoporosis, menopausal status, duration of menopause, the presence of chronic diseases (hypertension, diabetes mellitus, hyperlipidaemia, coronary artery disease, hypothyroidism) and radiological stage of knee OA were gathered from all patients. Also, serum calcium, Mg, alkaline phosphatase, parathyroid hormone (PTH) and 25(OH)-vitamin D levels were recorded. Additionally, dual-energy X-ray absorptiometry (DEXA) was used to measure the BMD of the lumbar vertebrae (L1-L4) and femoral neck as well as anteroposterior radiography of the knee in all patients. T scores ≤-2.5 were accepted as evidence of osteoporosis. The mean age of the study population was 59.15 ± 10.58 years.

The level of Mg significantly correlated with age, smoking, presence of chronic disease, duration of menopause, the level of vitamin D and PTH, and femoral neck T score (p<0.05). This study provides data supporting the relationship between magnesium levels and PTH and vitamin D levels, bone mineral density, and chronic disease. Future research is needed to examine the potential link between knee osteoarthritis and magnesium status.

Knee osteoarthritis pain reduced by 4,000 IU of Vitamin D for 3 months (35 ng avg.) – Dec 2022

The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis
Immunol Res . 2022 Dec 26. doi: 10.1007/s12026-022-09354-0
Ana Divjak 1 2, Ivan Jovanovic 3, Aleksandar Matic 4 5, Aleksandra Tomic Lucic 6 7, Nevena Gajovic 3, Milena Jurisevic 8, Aleksandra Jurisic Skevin 1 2, Mirjana Veselinovic 9 10

This trial aimed to determine the possible therapeutic and immunomodulatory effects of vitamin D3 in patients with knee OA. In this open-label clinical trial, symptoms were assessed over 3 months in patients with primary knee OA receiving oral vitamin D3 4000 IU/day. Clinical response was evaluated at baseline and 3 months using WOMAC subscores and VAS. Serum levels of cytokines IL-1ß, TNF-a, IL-13, IL-17, IL-33, IL-4, and IL-10 were determined by ELISA method. Eighty patients with knee OA were included. All 80 completed the study; the median 25(OH)D3 level was 23.1 ng/ml at baseline and increased by 12.3 ng/ml after treatment. Vitamin D3 after 3 months of supplementation induced a significant reduction in VAS pain and WOMAC subscores. Using OMERACT-OARSI criteria, 86.7% of patients treated with vitamin D3 responded to treatment. At the end of 3 months, systemic values of IL-1ß (p < 0.01), IL-23 (p < 0.01), and IL-33 (p < 0.01) were significantly increased, values of TNF-a (p < 0.01), IL-13 (p < 0.01), and IL-17 (p < 0.01) were significantly decreased, while value of IL-4 was not significantly changed. No adverse events were detected. Treatment with vitamin D is associated with improvement in pain, as well as stiffness and physical function. Vitamin D supplementation increased systemic values of IL-33. Our results indicate that vitamin D3 supplementation may be used as a novel therapeutic in knee OA. Future studies are needed to investigate a potential role of IL-33 in the pathogenesis of knee OA.

Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression - May 2023

 Download the PDF from VitaminDWiki

VitaminDWiki - 5 studies in both categories Osteoarthritis and Intervention

This list is automatically updated

VitaminDWiki - Osteoarthritis category contains

61 items total - see also Overview Osteoporosis and vitamin D

Overview Osteoarthritis and Vitamin D
Knee Osteoarthritis treated by Vitamin D - meta-analysis Aug 2023
See also Ankylosing spondylitis
Rheumatic Diseases often treated by Vitamin D, may need 40-60 ng – Oct 2021
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020

Click here for 2014 study

VitaminDWiki - Pain - chronic category contains

168 items in category Chronic pain

See also

28+ VitaminDWiki pages with KNEE OSTEOARTHRITIS in title

This list is automatically updated

Items found: 28
Title Modified
ACL Knee surgery increases risk of subsequent Knee Osteoarthritis by up to 2X (both low D) – Sept 2024 19 Sep, 2024
Knee osteoarthritis treated by Vitamin D - many studies 13 Dec, 2023
Knee Osteoarthritis treated by vitamin D if use more than 2,000 IU daily or non-daily high dose – meta-analysis Aug 2023 21 Aug, 2023
I needed more than Vitamin D to treat my knee osteoarthritis 06 Nov, 2021
Knee osteoarthritis helped by Low Level Laser Therapy 02 Nov, 2020
Knee osteoarthritis: Vitamin D is the 4th best treatment – meta-analysis Oct 2020 21 Oct, 2020
Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018 10 Oct, 2018
Knee Osteoarthritis benefited by 20 ng of Vitamin D for 5 years – RCT July 2018 10 Jul, 2018
Knee osteoarthritis helped by vitamin D2 (40,000 IU weekly raised 57 % above 30 ng) June 2017 29 Jul, 2017
Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015 29 Jul, 2017
Reduced knee osteoarthritis if consistently supplement with vitamin D for 2 years – April 2017 29 Jul, 2017
Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015 20 Jul, 2017
Knee osteoarthritis not helped by Vitamin D (when you ignore vitamin D levels) – April 2017 25 Apr, 2017
Knee osteoarthritis strongly associated with low Boron – 2015 24 Mar, 2017
Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013 24 Dec, 2016
Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016 21 Dec, 2016
Hypothesis- Knee osteoarthritis is reduced by vitamin D increasing level of nitric oxide – Dec 2013 06 Oct, 2016
Good evidence for knee osteoarthritis and vitamin D, unsure of other OA – Review March 2013 06 Oct, 2016
Knee osteoarthritis reduced somewhat by 50,000 IU vitamin D monthly (need more) – RCT Aug 2015 08 Mar, 2016
Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015 03 Oct, 2015
Will knee osteoarthritis be prevented with 1700 IU of vitamin D – proposed RCT 08 Aug, 2015
Knee osteoarthritis more painful if low vitamin D, especially among obese – Jan 2015 12 Apr, 2015
Knee Osteoarthritis 3.2X more likely to get worse if low Vitamin D and high PTH – Dec 2014 23 Feb, 2015
Knee osteoarthritis 2.3 X more likely to get worse if low level of vitamin D – Dec 2014 07 Oct, 2014
Blacks had lower vitamin D and more quantifiable pain than whites with knee osteoarthritis – Nov 2012 11 May, 2014
Probability of knee osteoarthritis up 50 percent if 20 ng less vitamin D – Nov 2011 10 Nov, 2012
Knee osteoarthritis associated with low vitamin D for those under age 55 – Dec 2010 10 Nov, 2012
Knee Osteoarthritis pain cut in half by eating sesame seed powder for 2 months - Oct 2019 No value for &#039;modification_date_major&#039;
Study References (2022)
  1. Orlowsky EW, Kraus VB. The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive. J Rheumatol. 2015;42(3):363–71. https://doi.org/10.3899/jrheum.140382
  2. Rainbow R, Ren W, Zeng L. Inflammation and joint tissue interactions in oa: implications for potential therapeutic approaches. Arthritis. 2012;2012:741582. https://doi.org/10.1155/2012/741582
  3. Wang Y, Teichtahl AJ, Pelletier JP, et al. Knee effusion volume assessed by magnetic resonance imaging and progression of knee osteoarthritis: data from the osteoarthritis Initiative. Rheumatology (Oxford). 2019;58(2):246–53. https://doi.org/10.1093/rheumatology/key274
  4. Wang K, Xu J, Hunter DJ, Ding C. Investigational drugs for the treatment of osteoarthritis. Expert Opin Invest Drugs. 2015;24:1539–56. https://doi.org/10.1517/13543784.2015.1091880
  5. Wang XB, Zhao FC, Yi LH, et al. MicroRNA-21-5p as a novel therapeutic target for osteoarthritis. Rheumatology (Oxford). 2019;58(8):1485–97. https://doi.org/10.1093/rheumatology/kez102
  6. Cao Y, Winzenberg T, Nguo K, Lin J, Jones G, Ding C. Association between serum levels of 25-hydroxyvitamin D and osteoarthritis: a systematic review. Rheumatology (Oxford). 2013;52(7):1323–34. https://doi.org/10.1093/rheumatology/ket132
  7. Aranow C. Vitamin D and the immune system. J Investig Med. 2011;59(6):881–6. https://doi.org/10.2310/JIM.0b013e31821b8755
  8. Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7:33–42. https://doi.org/10.1038/nrrheum.2010.196
  9. Wojdasiewicz P, Poniatowski LA, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediators Inflamm. 2014;2014:561459. https://doi.org/10.1155/2014/561459
  10. Rai V, Radwan MM, Agrawal DK. IL-33, IL-37, and vitamin D interaction mediate immunomodulation of inflammation in degenerating cartilage. Antibodies. 2021;10(4):41. https://doi.org/10.3390/antib10040041
  11. Pavlovic S, Zdravkovic N, Radosavljevic G, et al. Interleukin-33/ST2: a new signaling pathway in immunity and immunopathology. Vojnosanit Pregl. 2012;69(1):69–77. https://doi.org/10.2298/vsp1201069p
  12. Dinarello CA. Overview of the IL-1 family in innate inflammation and acquired immunity. Immunol Rev. 2018;28:8–27. https://doi.org/10.1111/imr.12621
  13. Shipton EA, Shipton EE. Vitamin D and pain: vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. Pain Res Treat. 2015;2015:904–67. https://doi.org/10.1155/2015/904967
  14. Alkan G, Akgol G. Do vitamin D levels affect the clinical prognoses of patients with knee osteoarthritis? J Back Musculoskelet Rehabil. 2017;30(4):897–901. https://doi.org/10.3233/BMR-160589
  15. Zhang FF, Driban JB, Lo GH, et al. Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014;144(12):2002–8. https://doi.org/10.3945/jn.114.193227
  16. Glover TL, Horgas AL, Fillinbim RB, Goodin BR. Vitamin D status and pain sensitization in knee osteoarthritis: a critical review of the literature. Pain Manag. 2015;5:447–53. https://doi.org/10.2217/pmt.15.43
  17. Stannus OP, Jones G, Blizzard L, Cicuttini FM, Ding C. Associations between serum levels of inflammatory markers and change in knee pain over 5 years in older adults: a prospective cohort study. Ann Rheum Dis. 2013;72(4):535–40. https://doi.org/10.1136/annrheumdis-2011-201047
  18. Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis. 1957;16(4):494–502. https://doi.org/10.1136/ard.16.4.494
  19. Bellamy N, Bell MJ, Goldsmith CH, et al. Evaluation of WOMAC 20, 50, 70 response criteria in patients treated with hylan G-F 20 for knee osteoarthritis. Ann Rheum Dis. 2005;64:881–5. https://doi.org/10.1136/ard.2004.026443
  20. Pham T, Van Der Heijde D, Altman RD, et al. OMERACT-OARSI initiative: osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited. Osteoarthr Cartil. 2004;12:389–99. https://doi.org/10.1016/j.joca.2004.02.001
  21. Jovanovic M, et al. Metabolic syndrome attenuates ulcerative colitis: correlation with interleukin-10 and galectin-3 expression. World J Gastroenterol. 2019;25:6465–82. https://doi.org/10.3748/wjg.v25.i43.6465
  22. Wu Z, Malihi Z, Stewart AW, Lawes CM, Scragg R. Effect of vitamin D supplementation on pain: a systematic review and meta-analysis. Pain Physician. 2016;19:415–27.
  23. Hussain S, Singh A, Akhtar M, et al. Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials. Rheumatol Int. 2017;37:1489–98. https://doi.org/10.1007/s00296-017-3719-0
  24. Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013;471:3556–62. https://doi.org/10.1007/s11999-013-3201-6
  25. Jin X, Jones G, Cicuttini F, et al. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA. 2016;315(10):1005–13. https://doi.org/10.1001/jama.2016.1961
  26. Arden NK, Cro S, Sheard S, et al. The effect of vitamin D supplementation on knee osteoarthritis, the video study: a randomised controlled trial. Osteoarthr Cartil. 2016;24:1858–66. https://doi.org/10.1016/j.joca.2016.05.020
  27. Mc Alindon T, Lavalley M, Schneider E, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis. JAMA. 2013;309:155–62. https://doi.org/10.1001/jama.2012.164487
  28. Gao XR, Chen YS, Deng W. The effect of vitamin D supplementation on knee osteoarthritis: a meta-analysis of randomized controlled trials. Int J Surg. 2017;46:14–20. https://doi.org/10.1016/j.ijsu.2017.08.010
  29. Diao N, Yang B, Yu F. Effect of vitamin D supplementation on knee osteoarthritis: a systematic review and meta-analysis of randomized clinical trials. Clin Biochem. 2017;50:1312–6. https://doi.org/10.1016/j.clinbiochem.2017.09.001
  30. Zhao ZX, He Y, Peng LH, et al. Does vitamin D improve symptomatic and structural outcomes in knee osteoarthritis? A systematic review and meta-analysis. Aging Clin Exp Res. 2021;33(9):2393–403. https://doi.org/10.1007/s40520-020-01778-8
  31. Tateiwa D, Yoshikawa H, Kaito T. Cartilage and bone destruction in arthritis: pathogenesis and treatment strategy: a literature review. Cells. 2019;8(8):818. https://doi.org/10.3390/cells8080818
  32. Glover TL, Horgas AL, Fillingim RB, Goodin BR. Vitamin D status and pain sensitization in knee osteoarthritis: a critical review of the literature. Pain Manag. 2015;5(6):447–53. https://doi.org/10.2217/pmt.15.43
  33. Martens P, Gysemans C, Verstuyf A, Mathieu C. Vitamin D’s effect on immune function. Nutrients. 2020;12:1248. https://doi.org/10.3390/nu12051248
  34. Milosavljevic MZ, Jovanovic IP, Pejnovic NN, et al. Deletion of IL-33R attenuates VEGF expression and enhances necrosis in mammary carcinoma. Oncotarget. 2016;7(14):18106–15.
  35. Griesenauer B, Paczesny S. ST2/IL-33 axis in immune cells during inflammatory diseases. Front Immunol. 2017;8:475. https://doi.org/10.3389/fimmu.2017.00475
  36. Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B. IL-33- activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol. 2011;41(6):1675–86. https://doi.org/10.1002/eji.201041033
  37. Jovanovic I, Pejnovic N, Radosavljevic G, Arsenijevic N, Lukic ML. IL-33/ST2 axis in innate and acquired immunity to tumors. OncoImmunology. 2012;1(2):229–31. https://doi.org/10.4161/onci.1.2.18131
  38. Jovanovic I, Radosavljevic G, Mitrovic M, et al. ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma. Eur J Immunol. 2011;41(7):1902–12. https://doi.org/10.1002/eji.201141417
  39. Jovanovic I, Pejnovic N, Radosavljevic G, et al. Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoural accumulation of immunosuppressive and innate lymphoid cells. Int J Cancer. 2014;134(7):1669–16682. https://doi.org/10.1002/ijc.28481
  40. He Z, Song Y, Yi Y, et al. Blockade of IL-33 signalling attenuates osteoarthritis. Clin Transl Immunol. 2020;9(10):e1185. https://doi.org/10.1002/cti2.1187
  41. De Martinis M, Ginaldi L, Sirufo MM, et al. IL-33/vitamin D crosstalk in psoriasis-associated osteoporosis. Front Immunol. 2021;11:604055. https://doi.org/10.3389/fimmu.2020.604055
  42. Sirufo MM, Ginaldi L, Martinis DE, M,. The IL-33/ST2 axis and vitamin D as a possible emerging therapeutic target in osteoarthritis. Rheumatology (Oxford). 2021;60(8):e300. https://doi.org/10.1093/rheumatology/keab292
  43. Annalora AJ, Jozic M, Marcus CB, Iversen PL. Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand in dependent functions. Toxicol Appl Pharmacol. 2019;364:55–67. https://doi.org/10.1016/j.taap.2018.12.009
There have been 169914 visits to this page


Knee osteoarthritis treated by Vitamin D - many studies        
158452 visitors, last modified 19 Sep, 2024,
(Cached) Printer Friendly Follow this page for updates
Page actions
Refresh Print
Edit Files 1

Attached files

ID Name Comment Uploaded Size Downloads
19530 matrix metalloprotease_CompressPdf.pdf admin 01 May, 2023 684.58 Kb 276