Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021

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Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial

Brain and Behaviour https://doi.org/10.1002/brb3.2342
Masoumeh Rajabi-Naeeni,Mahrokh Dolatian,Mostafa Qorbani,Amir Abbas Vaezi,

Purpose
Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes. The present study was conducted to determine the effectiveness of omega-3 and vitamin D co-supplementation on psychological distresses in women of reproductive age with pre-diabetes and hypovitaminosis D.

Methods
The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega-3 group), group 3 (vitamin D group), and group 4 (co-supplement group). The medication and placebo doses being two 1000-mg tablets each day for omega-3 and 50,000-IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.

Results
A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co-supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05).

Conclusion
Vitamin D and omega-3 co-supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre-diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.

Clinical trial registry
Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
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Intervention of Vitamin D for Depression

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Meta-analyses of Vitamin D and Depression

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VitaminDwiki - Depression category listing has 268 items along with related searches

Intervention of Omega-3 for Depression

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VitaminDwiki - Sleep category starts with

101 items in sleep category

A few items in SLEEP category

• Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
• Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
• Sleep, Dr. Gominak and Vitamin D - several studies
• Restless Legs Syndrome dramatically reduced by vitamin D, etc
• On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
• Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
• The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
• The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
• Vitamin D for better sleep video - Dec 2021
• 5X increase in sleep problems in a decade in US Veterans
• Sleep Apnea and Vitamin D - many studies
• Melatonin and Vitamin D - many studies does much more than improve sleep

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Sleep and Omega-3:

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11+ items with Anxiety in the title

This list is automatically updated

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VitaminDwiki - Vitamin D and Omega-3 category contains

409 Omega-3 items in category Omega-3 helps with: Autism (7 studies), Depression (28 studies), Cardiovascular (34 studies), Cognition (52 studies), Pregnancy (44 studies), Infant (34 studies), Obesity (14 studies), Mortality (7 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
CIlck here for details