- Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials
44 Virus Meta-analyses
Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials
Front. Pharmacol., 26 May 2024 Volume 15 - 2024 | https://doi.org/10.3389/fphar.2024.1367686
Yiyuan YangYiyuan YangWanli SunWanli SunFan YangFan YangGuoxia ZhangGuoxia ZhangXinye LiXinye LiShipeng Sun
Shipeng Sun*Yanwei Xing
Yanwei Xing* Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
Background: The therapeutic effects of vitamin D supplementation on Coronavirus disease 2019 (COVID-19) aggravation remain controversial and inconclusive. To probe into this contentious issue, we performed the present meta-analysis of randomized controlled trials (RCTs).Methods: Literature published up to June 2023 was retrieved from Cochrane Library, PubMed, Web of Science and Embase. RCTs assessing mortality,
- intensive care unit (ICU) admission,
- mechanical ventilation (MV),
- length of hospitalization (LOH), and
- inflammatory markers containing
- C-reactive protein (CRP),
- D-dimer,
- interleukin-6 (IL-6),
- lactate dehydrogenase (LDH) were included.
19 RCTs were involved in the analysis and were conducted subgroup analyses on the baseline COVID-19 severity and vitamin D administration.
Results: In the severity subgroup, statistically significant effects in moderate to severe group were observed in
- ICU admission (OR 0.43, 95% CI 0.23, 0.80; p = 0.008),
- MV (OR 0.44, 95% CI 0.27, 0.72; p = 0.001) and
- LOH (SMD –0.49, 95% CI –0.92, −0.06; p = 0.027).
In the administration subgroup,
- effects of ICU admission (OR 0.39, 95% CI 0.16, 0.97; p = 0.044),
- MV (OR 0.18, 95% CI 0.07, 0.46; p = 0.000) and
- LOH (SMD –0.50, 95% CI –0.96, −0.04; p = 0.034)
were more pronounced in patients supplied with multiple-dose vitamin D than single-dose. Although the result of mortality showed no statistically significant effect, it indicated a reduced trend (OR 0.87, 95% CI 0.63, 1.12; p > 0.05). The results of inflammatory markers reached no statistical differences.
Conclusion: This meta-analysis revealed that moderate to severe COVID-19 patients supplied with multiple doses of vitamin D were less apt to need ICU admission, mechanical ventilation and have shorter hospital stays.
Download the PDF from VitaminDWiki
study was reviewed in Trial Site News
44 Virus Meta-analyses Short URL for this section = is.gd/vdwmeta
- COVID ICU use reduced by 42% if take more than 100,000 IU of vitamin D over two weeks – meta-analysis Sept 2024
- Vaccinations did not stop COVID (68 studies) – meta-analysis May 2023
- Influenza risk cut in half by the only trial giving enough vitamin D for body weight – meta-analysis Jan 2022
- Multiple Vitamin D doses reduced COVID ICU by 2.5 X , Mech. Ventilation by 5.5 X – meta-analysis May 2024
- COVID death rate in hospital halved if take any amount of vitamin D for any length of time – meta-analysis May 2024
- COVID and Vitamin D: 2X more likely to die if low, 2X more likely to survive if supplement – umbrella meta-analysis April 2024
- COVID fought by Vitamin D: 2.3X less likely to die of COVID if supplemented, 1.9 X less likely to become infected – meta-analysis March 2024
- COVID Vaccinations increased risk of cardiac deaths in youths by 19% - Aug 2023
- T1 Diabetes increased by 27% by second year of COVID – meta-analysis June 2023
- Yet another reason to take Vitamin D while pregnant – fight COVID - meta-analysis May 2023
- COVID death 1.5 X less likely if high vitamin D, emergency D (50K to 100K) is great – meta-analysis March 2023
- COVID ICU 3X less-likely if take any amount and type of Vitamin D – meta-analysis Jan 2023
- COVID and Vitamin D: any amount of D, at any time, for any duration reduced ICU - meta-analysis Dec 2022
- Worse COVID during 3Q pregnancy if 2.5 ng lower Vitamin D – meta-analysis Sept 2022
- Severe COVID 2.6 X less likely if supplement with Vitamin D – 26th meta-analysis - July 2022
- COVID Long-Haul prevalence increases with time: 50% at 4 months - meta June 2022
- COVID test positive is about half as likely if have Vitamin D – 24th meta-analysis - Jan 2022
- Small amounts of Vitamin D reduce Influenza risk by 22 percent (loading dose is far better) – meta-analysis Jan 2022
- Vitamin D fights COVID (54 studies of 1,400,000 people) – 23rd meta-analysis - Dec 2021
- COVID-19 treated by Vitamin D (reduce ICU by 3X) - 22nd meta-analysis - Dec 29, 2021
- COVID-19 death increased 2X if low Vitamin D (less than 10 to less than 30 ng) – 21st meta-analysis Dec 2021
- COVID-19 risk reduced by vitamin D supplementation – umbrella review of 7 meta-analysis – Oct 2021
- COVID-19 treated by Vitamin D (example: ICU reduced by 5X) – 20th meta-analysis Oct 13, 2021
- Severe COVID-19 2.5 X more likely if low vitamin D (23 studies) – 19th meta-analysis Oct 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- COVID-19 death 1.6 X more likely if low vitamin D (24 studies) – 17th meta-analysis Aug 2021
- Severe COVID-19 5X more likely if low vitamin D (23 studies) – 16th meta-analysis July 2021
- Severe COVID-19 3.5 more likely if low vitamin D (30 studies) – meta-analysis July 2021
- COVID-19 patients who had supplemented with Vitamin D were 3X less likely to enter ICU – June 2021
- Low Calcium associated with severe COVID-19 – several studies
- COVID-19 mortality 3X more likely if low vitamin D (999,179 people) – meta-analysis March 29, 2021
- COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis March 26, 2021
- Low Vitamin D associated with 2.7X more severe COVID-19 – 12th MA March 5, 2021
- Vitamin D supplementation fights COVID-19 – 11th meta-analysis Jan 24, 2021
- 3.7 X less likely to die of COVID-19 if supplemented with Vitamin D - meta-analysis Jan 5, 2021
- Less likely to test positive for COVID-19 if higher Vitamin D – meta-analysis Jan 6, 2021
- Vitamin D reduces COVID-19 by 80 percent - anonymous meta-analysis - Jan 5, 2021
- COVID-19 1.7X more likely to be severe if low Vitamin D - meta-analysis Oct 2020
- Low Vitamin D associated 1.8X increased risk of COVID-19 death in hospital – meta-analysis Nov 4, 2020
- Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020
- Prudent to consider that Vitamin D has a role in COVID-19 – meta-analysis – Aug 7, 2020
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
- Hepatitis B patients have 2 ng lower level of Vitamin D – meta-analysis June 2019
- Influenza Vaccination not benefited by lowish levels of vitamin D – meta-analysis March 2018
Multiple Vitamin D doses reduced COVID ICU by 2.5 X , Mech. Ventilation by 5.5 X – meta-analysis May 2024(Cached) Printer Friendly Follow this page for updates26487 visitors, last modified 22 Jul, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 21289 COVID multi-dose.webp admin 09 Jun, 2024 8.27 Kb 71 21288 COVID meta may 2024_CompressPdf.pdf admin 09 Jun, 2024 906.31 Kb 77