Vitamin D helps organ transplant - many studies

Created January 2011

Summary of many studies of Vitamin D and organ transplantation

More vitamin D needed especially needed if organ = liver or kidney (low vitamin d ==> poor bones)

Both regular and active vitamin D have been used

Supplementation can be oral, injection, etc

Extra Vitamin D can be before or after the surgery

Problems avoided include: infection, rejection, death

33+ VitaminDWiki pages have TRANSPLANT (not FECAL) in the title

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Vitamin D in organ transplantation - 2011

Osteoporos Int. 2011 Jan 5.

Stein EM, Shane E.

Department of Medicine, Columbia University Medical Center, 630 West 168th Street, PH8-864, New York, NY, 10032, USA, es2029@columbia.edu.

Vitamin D deficiency is prevalent among patients with end-stage organ failure awaiting transplant. Low serum 25-hydroxyvitamin D (25-OHD) levels in these patients may be related to many disease-specific factors, as well as decreased sunlight exposure and limited intake of foods containing vitamin D.

Low serum 25-OHD levels are also extremely common following solid organ transplantation, both during the immediate postoperative period and in long-term graft recipients.

Demographic and lifestyle factors are important in determining D status in transplant recipients.

Worse vitamin D status is associated with poorer general health, lower albumin, and even decreased survival among these patients.

Although several studies have demonstrated that active forms of vitamin D and its analogues prevent bone loss following transplantation, the data do not show consistent benefit.

These therapies may have particular utility after renal transplantation. However, given the narrow therapeutic window with respect to hypercalcemia and hypercalciuria , and the demonstrated efficacy of bisphosphonates to prevent post-transplantation bone loss, we regard these agents as adjunctive rather than primary therapy for transplantation osteoporosis.

The effects of 1,25(OH)(2)D on the immune system, which are still being elucidated, may have potential for reducing infections and preventing allograft rejection after transplantation. PMID: 21207011

Cited by 70 later studes as of March 2021

Vitamin D Receptor Activity, Vitamin D Status, and Development of De-novo Donor-specific Antibody after Renal Transplantation - March 2020
- 📄 Download the PDF from VitaminDWiki

Survive heart transplant better if have more vitamin D

PDF is attached at the bottom of this page

Immune system is often supressed so that a new organ can be accepted by the body

But, the immune syetem is needed to avoid COVID-19

immunosuppressants National Kidney Foundation
COVID-19: Issues related to solid organ transplantation Feb 2021
'It's Kind of a Catch-22': Immunosuppression and COVID-19 Vaccines MedPageToday, March 23, 2021
- "A recent study found fewer than 20% of solid organ transplant patients mounted detectable antibodies to SARS-CoV-2 following a first dose of COVID-19 vaccine, raising questions about vaccine protection in this population compared to immunocompetent people."
- "Now in transplant patients, what we found is that only 17% have detectable antibody after dose one . "
26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Includes immunosuppression as a risk factor
General Approach to the Clinical Care of Solid Organ Transplant Recipients with COVID-19 Infection: Management for Transplant Recipients - Oct 2020 📄 PDF