Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT

Created January 2021

High dose vitamin D improves total serum antioxidant capacity and ICU outcome in critically ill patients - a randomized, double-blind clinical trial

European Journal of Integrative Medicine https://doi.org/10.1016/j.eujim.2020.101271

Mohammad istanizadab Mehran Kouchek cMir Mohammad MiricSaraSalarianc Seyedpouzhia ShojaeicFatemeh Moini Vasegha Hossein Seif iKafshgarid Roja Qobadighadikolaeie

1. # Items in both categories Loading Dose and Trauma / Surgery: {category} 1. # Items in both categories Injection and Trauma / Surgery: {category} --- 1. # Note: Injections take several days longer to restore Vitamin D levels than other forms It seems that oral would be preffered over injection if the person could swallow and had a functioning gut Muscosal vitamin D (under the tongue) would be much faster than both oral and injection 1. It is probably better to get Vitamin D levels restored as soon as possible, and perhaps eliminate the ICU * Improve your health BEFORE surgery (prehabilitation) helps your recovery - 2018 * Smokers should stop 1 month before surgery W.H.O. – Jan 2020 * Give Vitamin D before all spinal surgeries – no testing needed – June 2020 * Vitamin D before surgery often helps (Thyroidectomy in this case) – Sept 2019 * Getting Vitamin D before heart surgery prevented Afib in those who had been deficient – July 2018

Introduction

Mechanical ventilation can increase the rate of free radicals in the systemic circulation due to its effect on the inflammatory system. Previous research has suggested that vitamin D has antioxidant properties. This study aimed to evaluate the effect of vitamin D on total Antioxidant Capacity (TAC) and its relationship with ICU patients' outcomes.

Methods

In this prospective randomized clinical trial, 36 ventilated ICU patients were randomly allocated to receive either a single intramuscular vitamin D 300,000 IU or its placebo. Serum Vitamin D and TAC were measured before and on day 7 after the intervention. clinical Pulmonary Infection Score (CPIS) and sequential organ failure assessment (SOFA) scores were measured daily for seven days and on days 14 and 28.

Results

Thirty patients completed the study. The results show that injection of vitamin D leads to a significant increase in the mean changes of vitamin D level on the seventh day of the study (+3.5±1.3 vs -0.4±0.2 P=0.00) and TAC levels (3.2±3.9 vs -2.0±2.6 P=0.00. ICU length of stay was 18.3±8.4 and 25.4±6.6 days in the intervention and placebo arms of the study. Twelve patients in the placebo group and 5 in the vitamin D group died within the 28 day study period. The duration of mechanical ventilation was 15.7± 9.3 vs. 22.6± 9.1 days in vitamin D and placebo arms, respectively.

Conclusion

: Administration of vitamin D may increase TAC levels and decrease the length of stay and duration of mechanical ventilation in ICU patients

Tags: Injection Intervention Loading dose Trauma and surgery