Overview MS and vitamin D

Created August 2010

MS and Vitamin D Overview

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Fact: Low Vitamin D results in higher risk of getting MS
- Increase latitude leads to decreased Vitamin D, which leads to increased risk of MS
- Dark skinned people are far more likely to get MS (dark skin people typically have low vitamin D)
- Elderly (who typically have low vitamin D) are more likely to get MS
- Is there increased risk in people who already have diseases associated with low vitamin D - TB, for example ? ? ?
- Women typically have 3X increased MS risk then men (note: women typically have 20% lower levels of vitamin D than men)
- Exception: women in very sunny climates and dark-skinned women have the same MS risk as men
- Obese are 60% more likely to get MS
- Multiple Sclerosis 42X more likely if light brown skin and smoke (both associated with low vitamin D) – July 2020
- MS recurrence is much higher in spring - the lowest time of the year for vitamin D
- increase in clouds/rainfall (which reduces available Vitamin D) is associated with increased risk of MS (Scotland, Western Washington)
- MS incidence has increased 70% in a decade while the incidence of vitamin D deficiency doubled
- Less MS in those with outdoor occupations PDF file, not a web page
Fact: MS uses up Vitamin D
Fact: Lower vitamin D (due to MS using up Vitamin D while fighting the disease) results in many other health problems (such as broken bones), so depleted vitamin D levels must be restored.
Fact: Vitamin D looks so promising for preventing and treating MS that there were 25 INTERVENTION clinical trials as of Feb 2014
Fact: Vitamin D reduced the MS relapse rate far better than Fingolimod which is now used for that purpose.
- Note: Fingolimod costs $25,000/year while vitamin D, which works better and has no side effects is 1000 times less expensive.
Fact: 98% of the genes affected by Interferon are also affected by Vitamin D
- Note: 1 week of Interferon = $4,700, 1 week of vitamin D 10,000X lower cost
Fact: MS Doctors in Brazil recommending 40-100 ng/mL of Vitamin D
Fact: Many MS forums are recommending vitamin D to treat MS, with some taking 5,000 to 10,000 IU daily
- Observation: Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT Dec 2012
  - This is an observation instead of a fact - it has not yet been confirmed.
Fact: VERY LARGE doses of vitamin D have CURED 2,000 people of MS in Brazil
Controversy: UVB fron sunlight or UVB bulb may be BETTER than Vitamin D for reducing the risk of getting MS
Hypothesis: In addition to Vitamin D there are many other photoproducts produced by UVB that may promote health.

Summary: lack of consensus on how much to prevent, treat, or cure MS.
Coimbra Protocol (using Vitamin D) is safe and effective for Multiple Sclerosis and Autoimmune diseases – April 2022
54,000 IU of vitamin D daily with no Calcium (1,000 IU per kg: Coimbra protocol) – July 2024
How much Vitamin D to prevent many diseases - such as MS
How much Vitamin D is needed to treat MS? There is currently no agreement
- The recommendations range from 40 to 100 ng - which can result of a dose ranging from 3,000 to 20,000 IU/day
How Vitamin D is needed to Cure MS? : It appears that 20,000-140,000 IU daily may be needed to CURE the disease
- You must be under the supervision of a doctor who knows what to watch for in your individual situation.
- High doses of Vitamin D cannot be used as a monotherapy.
- You will need to adjust the cofactors: Typically increasing Magnesium and Vitamin K2, and reducing Calcium intake.
- Your doctor will monitor these and might increase your intake of Vitamins B2, C, as well as Omega-3
Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022
Multiple Sclerosis treated by Vitamin D, recommends investigating high dose Coimbra - Oct 2021
Multiple Sclerosis patients had fewer COVID-19 problems (Note: many MSers take Vitamin D) – April 30, 2021
Vitamin D Resistance hypothesis confirmed by Coimbra high-dose vitamin D protocol – April 2021
Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019

Multiple Sclerosis category has items along with related searches

which lists items which are in MA and another category: Autoimmune 33; UV 21; Genetics 20; Intervention 18; Parkinson 15; High-Dose 15; Cognitive 14; Pregnancy 11; Receptor 10; Lupus 9; RA 9; Omega 9; Virus 9; Immunity 7; Psoriasis 7; Diabetes 6; Gut 6 etc.

Map of doctors using the Coimbra Protocol

Google Map

Forums and organizations are endorsing Vitamin D for MS

Vitamin D and MS ORG excellent need to add details
Patients like me web site shows that Vitamin D is used by more people with MS than with any other specific disease
Mega Doses of Vitamin D for MS PatientsLikeMe Dec 2015 9,700 messages on Vitamin D Megadose forum
Vitamin D at CureTogether: Fibromyalgia, MS, Psorasis, etc - Dec 2013
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Books on MS and Vitamin D

WHY IS THERE NO MULTIPLE SCLEROSIS AT THE EQUATOR, HOW BRAZILIAN DOCTORS ARE CURING MS WITH HIGH-DOSE D3
- March 2014. It uses many images and some text from VitaminDWiki.
High-Dose Vitamin D Therapy – book July 2018
Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 contains protocol description

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Health problems which occur up to 5 years before: Depression, constipation, UTIs, and sexual dysfunction

Depression, constipation, UTIs early signs of MS? MD Edge] Dec 2023

Study is behind a paywall

https://doi.org/10.1212/WNL.000000000020798

Considered 113 heatlh problems - found 5


Health Problem	Increased risk of MS
Depression	1.22
Sexual dysfunction	1.47
Constipation	1.5
Cystitis	1.21
UTIs	1.38

"Suspect the PDF will identify the increased risk if have 2 of the health problems"

Genes, MS, and Vitamin D

FACT: At least some MS is associated with a gene variant

FACT: People with MS need higher levels of vitamin D to treat the symptoms

SPECULATION: Those people with the gene variant need higher levels of vitamin D in the blood to prevent/treat MS

Multiple Sclerosis (MS) malady Malacards has the following graphic

Top 20 diseases related by genes to MS ( many of which are associated with low vitamin D)