Overview Gut and vitamin D

Created November 2016

* High level of vitamin D/UV reduces the risk of many gut problems * Many gut problems result in less absorption of Vitamin D & Magnesium . . . * Not restoring Vitamin D levels increases the risk of many other diseases * Increasing Vitamin D reduces many inflammations - incude those of the gut * Several companies make gut-friendly forms of vitamin D * There are ** * items in the Gut category in VitaminDWiki * (more GUT information below) {include}

Gut Summary

Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
Celiac disease has a strong genetic component.
- Most, but not all, people with celiac disease have a gene variant.
- An adequate level vitamin D seems to decrease the probability of getting celiac disease.
- Celiac disease causes poor absorption of nutrients such as vitamin D.
- Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
- The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
Review in Nov 2013 found that Vitamin D helped
- Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
All items in category gut and vitamin D items

There are many ways to get vitamin D to people with poor guts
- There is a low-cost form of vitamin D designed for use with gut problems

See VitaminDWiki (other than Crohn's)

9 gut problems - in order of prevelance - Perplexity AI June 2024

Irritable Bowel Syndrome (IBS) - Affects 12% of the US population, making it the most common digestive disorder.
Gastroesophageal Reflux Disease (GERD) - Along with IBS, GERD is noted as one of the digestive disorders seeing a noticeable rise in incidence.
Constipation - Chronic constipation affects 15-30% of Canadians and is especially common in young children and the elderly.
Inflammatory Bowel Disease (IBD) - IBD, which includes Crohn's disease and ulcerative colitis, had an estimated 4.9 million prevalent cases globally in 2019.
Gastritis - Inflammation of the stomach lining, commonly caused by H. pylori infection, NSAIDs, or alcohol.
Peptic Ulcers - Often associated with gastritis and caused by H. pylori infection or NSAID use.
Pancreatitis - Had an estimated 2.41 million prevalent cases globally in 2019.
Appendicitis - Had an estimated 0.67 million prevalent cases globally in 2019.
Paralytic Ileus and Intestinal Obstruction - Had an estimated 0.55 million prevalent cases globally in 2019.

4 gut problems are associated with low vitamin D levels - Perplexity AI June 2024

Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis:
- Vitamin D deficiency is more common among those with IBD.
- Lower vitamin D levels are associated with higher disease activity and severity in Crohn's disease.
- Vitamin D deficiency may be implicated in the etiology and severity of IBD.
- Individuals with higher serum vitamin D have a lower incidence of IBD, particularly Crohn's disease.
Constipation:
- A study found that patients with chronic functional constipation and intestinal motility disorders had lower vitamin D levels compared to healthy controls.
- Low vitamin D levels were significantly correlated with constipation symptoms and impaired quality of life in these patients.
Diarrhea:
- Low vitamin D levels are associated with an increased risk of rotaviral diarrhea in children under 5 years old.
- A study found lower vitamin D levels in children with acute bacterial diarrhea compared to healthy children.
General Gastrointestinal Inflammation:

Vitamin D plays a role in maintaining gastrointestinal barrier integrity, regulating gut microbiota, and modulating inflammatory immune responses, which are important in preventing and ameliorating gut inflammation.

References

87% of eating disorders got worse with COVID-19 - Aug 2020

Exploring the impact of the COVID-19 pandemic and UK lockdown on individuals with experience of eating disorders

UK study, FREE PDF

Many gut diseases will do better with gut-friendly forms of Vitamin D

Getting Vitamin D into your blood and cells has the following chart

Getting Vitamin D into your blood and cells also has the following {include}

Review of IBD and Vitamin D (generally < 1,000 IU) - Feb 2014

Review of observational and intervention studies

📄 Download the PDF from VitaminDWiki

SBI can help Colitis - Aug 2022

SBI = Serum-Derived Bovine Immunoglobulin/Protein Isolate,

by Eugene Heyden

IBS vs IBD

Colon Diseases

Celiac

Celiac assocated with both low vitamin D and poor Vitamin D Receptor - meta-analsys - Feb 2023

A meta-analysis suggests the association of reduced serum level of vitamin D and T-allele of Fok1 (rs2228570) polymorphism in the vitamin D receptor gene with celiac disease

Front Nutr . 2023 Jan 19;9:996450. doi: 10.3389/fnut.2022.996450

Tanya Shree 1, Pratibha Banerjee 1, Sabyasachi Senapati 1

Purpose: As an immune-modulator, vitamin D is known to regulate immune response and is implicated in disease pathogenesis. Celiac disease (CD) is a systemic autoimmune disease and susceptibility conferred by vitamin D metabolism is under investigation. Studies on the association of vitamin D metabolism and genetic polymorphisms are expected to explain CD pathogenesis. We performed a systematic review-based meta-analysis to investigate the 25(OH)D serum levels and susceptibility conferred by the genetic variants of VDR in CD.

Methods: Systematic review was conducted through a web-based literature search following stringent study inclusion-exclusion criteria. The Newcastle-Ottawa Scale and GRADE tools were used to assess the quality of evidence in studies and the study outcome. Cohen's κ value was estimated to access the reviewer's agreement. RevMan 5.4.1 was used to perform the meta-analyses. Weighted mean difference and Meta p-value was assessed for 25(OH)D serum levels. Meta-odds ratio and Z-test p-value were evaluated to estimate the allelic susceptibility of VDR variants.

Results: A total of 8 out of 12 studies were evaluated for "25(OH)D" serum level, while four studies were found eligible for SNPs (Bsm1, Apa1, Fok1, and Taq1) of VDR. Significantly higher levels [WMD = 5.49, p < 0.00001] of 25(OH)D were observed in healthy controls than in patients with CD. rs2228570-T (Fok1) [Meta-OR = 1.52, p = 0.02] was confirmed to be predisposing allele for CD.

Conclusion: Reduced serum level of 25(OH)D and association of Fok1 T-allele of VDR confirmed in this study plays a critical role in immunomodulation and maintaining barrier integrity, which is majorly implicated in CD.

📄 Download the PDF from VitaminDWiki

Celiac disease is the most common genetic disease in Europe.

In Italy about 1 in 250 people and in Ireland about 1 in 300 people have celiac disease.

from http://www.wrongdiagnosis.com/c/celiac_disease/prevalence.htm

Celiac Disease is similar to Crohn's Disease in that both decrease vitamin D which can be absorbed in the gut

Celiac Disease may be similar to Crohn's Disease on the following chart

Does Gluten-Free Diet Protect Children with Celiac Disease from Low Bone Density? - Aug 2014

📄 Download the PDF from VitaminDWiki.

They believe: CD ==> poor absorption ==> low vitamin D ==> low Bone Mineral Density

They conclude that if teen with CD has bone pain should have DXA test of BMD, then might consider giving vitamin D.

8 ✻ VitaminDWiki pages with CELIAC in title

This list is automatically updated

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Crohn's

Crohn's reduced by plant-based diet - Dr. Greger

Crohn's reactions to yeast, milk, eggs - good video review of many studies (video with transcript)- Feb 2021

Is Nutritional Yeast Healthy for Everyone? Dr. Greger

The Best Diet for Crohn’s Disease Treatment Video with transcript April 2021

Vitamin D levels OK months before Crohn's, but were low only after Crohn's

Presented at a medical conference June 2018 Military

Crohn's and Colitis infographic

39+ VitaminDWiki pages with CROHN in title