Overview Fractures and vitamin D

Bone Fractures can be decreased by:

• Build bone by having enough vitamin D (>1,000 IU) when also having cofactors such as Magnesium and Vitamin K-2
  • >4,000 IU for a wide variety of reasons
• Reduce falls by having enough vitamin D to maintain youthful nerve and muscle response time - again with cofactors

Supporting studies in VitaminDWiki

• All items in category Falls or Fractures and Vitamin D items

• Vitamin D In Older Women - Fractures, Frailty and Mortality – Buchebner thesis 2017

  • has the chart: Low Vitamin D ==> More fractures (3 paths)
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• Bone fractures in children requiring surgery were 55X more likely with low vitamin D – June 2015

• Hospital found that Vitamin D saves money by improving bone fracture healing– March 2016

• Acute fracture patients – 70 percent were vitamin D deficient – meta-analysis Sept 2015

• Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015

• 6500 IU vitamin D not improve bone density without co-factors – Jan 2012

• Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010

• Overview Osteoporosis and vitamin D

• Noticed bones heal faster when more than 60 ng of vitamin D

• Forearm fracture 3.5X more often in black children with low levels of vitamin D – Sept 2012

• Save 2 billion dollars annually in fractures if take Vitamin D and Calcium – Frost and Sullivan Sept 2013

• Would there be fewer stress and bone fractures with vitamin D?

• Many abstracts on fewer stress and bone fractures with vitamin D

• Half as many stress fractures for those with higher vitamin D see following chart

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• Osteoporosis medication 7X better when more than 33 ng of vitamin D – June 2011

• Causes, consequences, and treatment of osteoporosis in men– Aug 2013

• Vitamin D may prevent falls by itself – an overview of 9 meta-analysis – Oct 2012

• Following chart was presented back in 2003

• [dl2672] Literature review - PDF file, which has the following image

Meta-analyses of Falls and Fracture in VitaminDWiki

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Optimising Vitamin D Levels after Hip Fractures - 2017

Jenson Mak – book chapter

http://dx.doi.org/10.5772/66546

📄 Download the PDF from VitaminDWiki

Normally “ . . D levels significantly fall in the first 14 days following hip fracture”

4 weeks after hip fracture and 250,000 IU loading dose of vitamin D

      Far Fewer Falls, etc.

Hip in VitaminDWiki

• Total hip replacement: 14 times more likely to redo if low vitamin D – March 2017

• Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010

• Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015

• Search VitaminDWiki for "HIP FRACTURE" 577 items as of May 2016

• UK would save as least 636 million dollars annually by giving 800 IU vitamin D free to all seniors – June 2014 only considered hip fractures

• Hip fracture – not getting enough vitamin D – 2013

• Hip fracture 3X more likely if low vitamin D – Dec 2015

• Hip fracture 50 percent more likely if low in both vitamin D and vitamin K1 – Dec 2015

• Vitamin D needed to prevent and treat hip fracture, but only 20 percent got any – May 2013

• Hip fracture rate varies with latitude (and thus vitamin D) in Sweden – Nov 2013

• 5X increase in hip fracture rates in 65 years - 1998

• Delirium 2.7 X more likely after hip fracture and low vitamin D – May 2015

• Hip fracture outcome 5X more likely to be poor if low vitamin D – Jan 2015

• Hip fracture rate varies with latitude (and thus vitamin D) in Sweden – Nov 2013

• Hip fracture 19 percent less likely with just 4 ng higher level of vitamin D – Dec 2012

• Hip fractures greatly reduced by sunshine, vitamin D, and Vitamin K – meta-analysis Sept 2012

• Women with hip fractures very low on vitamins D3 and K – Mar 2011

• Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012

• Vitamin D 2nd most recommended way to prevent next hip fracture – Nov 2010 LTC was first

• Better total hip replacement if have high vitamin D – April 2010

• Is it ethical to not give vitamin D in osteoporosis trials?– NEJM Sept 2010

• Guideline following hip fracture – 50000 IU vitamin D daily for 7 days – Jan 2013

• Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016

General support in VitaminDWiki

• All items in Osteoporosis and Vitamin D items

• All items in Seniors Lack vitamin D items

• Seniors Vitamin D Workshop

• Overview Seniors lack Vitamin D

• All items in Rheumatoid Arthritis items

• All items in Bone Health items

• All items Pain - chronic, including Back Pain items

• CLICK HERE to use Google Site search of VitaminDWiki for spine or spinal. 4530 items Dec 2022

• Many reasons why vitamin D deficiency has become epidemic 38 reasons as of Dec 2022

CLICK HERE for Strong Bones and Vitamin D from Dr. Susan Ott at the University of Washington

• CLICK HERE for her long list of references on Vitamin D and Osteoporosis, Cancer, etc.

• Fraser Health in Canada is giving 20000 IU vitamin D weekly to reduce falls – Nov 2011

See also web

• "..only 9 percent of Medicare patients who sustained a hip or spinal fracture were tested for bone loss and offered treatment to head off a future fracture." NYT Sept 2021

• Hip Fractures in Older Adults - JAMA 2019

  • Most estimates of risk of elderly fracture do not consider the following:
  •     falls, cognitive impairment, urinary incontinence, neurological conditions, and medications
  • Continues to recommend Vitamin D sufficiency (>30ng?)
  • 📄 Download the PDF from VitaminDWiki
• The Healthy Bones, Healthy Aging Challenge May 2019
  • "Four out of five fracture patients are not diagnosed or treated for their osteoporosis.
  • After a first fracture, the risk of having another increases by 85%."
• New Cautions About Long-Term Use of Bone Drugs NYT May 2012
  • FDA warns in NEJM of problems with bisphosphonates and "little if any benefit from the drugs after three to five years of use"
• Does vitamin D help with fracture healing? March 2013, Vitamin D Council
  • Rat study documented that radioactive calcitriol (Active vitamin D) concentrated in fractures
  • 2013 study of humans found that serum levels of vitamin D dropped after fracture (18 down to 16 ng) and slowly returned back to 18 during healing
• A secular increase in BMD in Chinese women J Bone Miner Metab, April 2013
  • Increase in BMD in Chinese older women in just 10 years (2000 - 2010)
  • BMD: lumbar spine +4%, femoral neck +9%, and total hip +9%
  • Difference in 2010 vs 2000 cohorts: Longer reproductive years, higher levels of physical activity, higher estradiol and 25(OH) vitamin D levels, and lower alkaline phosphatase levels
• Ask Well: Exercises to Strengthen Bones New York Times, March 2014
  • increase bone density/strength with hopping, brisk walking, occasional movement other than forward, whole body vibration
  • No mention of vitamin D
• Cost-effectiveness analysis of hip fracture prevention with vitamin D supplementation: a Markov micro-simulation model applied to the French population over 65 years old without previous hip fracture April 2014
  • Conclusion of the study; more cost effective to test for vitamin deficiency then treat those who are low.
  • VitaminDWiki suspects that conclusion assumes a high cost of French doctors to treat, it is more cost effective to minimize treatment
• The Role of Vitamin D in Human Fracture Healing: A Systematic Review of the Literature May 2014
  • We conclude that vitamin D has a role in fracture healing, but the available data are too inconsistent to elucidate how and in what manner
• Review: In postmenopausal women and older men, vitamin D plus calcium reduces some fractures Sept 2014
  • Annals of Internal Medicine. NO ABSTRACT, Publisher wants $35 for the PDF
• Patients presenting with fractures are likely to be vitamin D deficient: are we getting enough sun?

12% reduced risk of hip fracture if high level of Omega-3/fish - 2019

Researchers reviewed the findings of 10 studies involving nearly 300,000 people.

Study