Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Global Journal of Health Science; Vol. 9, No. 3; 2017 ISSN 1916-9736 E-ISSN 1916-9744 Published by Canadian Center of Science and Education

Mansoureh Samimi1, Fatemeh Foroozanfard1, Farzaneh Amini1 & Mojtaba Sehat2

Department of Obstetric and Gynecology, Kashan University of Medical Sciences, Kashan, IR Iran

Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran

Correspondence: Farzaneh Amini, Department of Obstetric and Gynecology Shabih-Khani Hospital, Shahid Beheshti Street, Kashan, Isfahan, Iran. Tel: 98-31-5554-0021. E-mail: farzanehamini1384@gmail.com

Recurrent spontaneous abortion (least two consecutive or three non-consecutive pregnancy) before 12th week Supplementation: from first doctor visit to 12th week of pregnancy All women got vaginal progesterone – 400 mg per day.
Dose Vitamin D
nanograms		 Miscarriages
Vitamin D 400 IU 13 13%
Placebo 0 IU 11 34%
See also VitaminDWiki It is rare to find a benefit with just 400 IU of vitamin D Note: Vitamin D levels of women in the Middle East are VERY low, so even 400 IU can help * Vitamin D given to ALL high schools girls in Iran – 75 percent deficiency dropped to 6 percent – April 2016 * Saudi females twice as likely to be vitamin D deficient as males (cloth) – July 2015 * Overview Middle East and vitamin D * Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015 * Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016 * WHO still says mistakenly says NO vitamin D during pregnancy, and only 200 IU after * Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016 * Miscarriage 2 times more likely if low vitamin D – meta-analysis May 2017 * Second miscarriage associated with low vitamin D – review June 2018 Pregnancy category starts with {include}

Download the PDF from VitaminDWiki

Note: there are several mistakes in the following abstract which are clarified in the PDF text.

Background: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA).

Methods: A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively. The incidence of abortion and the serum levels of IL-23 were examined within 20 weeks of gestation.

Results: The levels of vitamin D3 prior to the start of the study were equal to 11.65±3.76 ng/ml and 11.53±2.39 ng/ml (p=0.86) in the intervention and control groups, respectively, which were decreased to 13.21±3.47 ng/ml and 11.08±2.76 ng/ml (p=0.004) at the end of the study, when the mean serum levels of IL-23 were equal to 18.4±3.78 pg/ml and 23.16±4.74 pg/ml in the two groups (p <0.004). The frequency of abortion in the control and intervention groups was equal to 5 (12.8%) and 13 (34.2%), respectively (p=0.03, OR=3.53, 95% CI= 1.12-11.2).

Conclusions: Vitamin D3 leads to decreased serum levels of IL-23 and incidence of abortion among women with URSA.