Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT

The effects of vitamin D3 supplementation on some metabolic and inflammatory markers in diabetic nephropathy patients with marginal status of vitamin D: A randomized double blind placebo controlled clinical trial

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Vol13, Issue 1, Jan–Feb 2019, Pages 278-283, https://doi.org/10.1016/j.dsx.2018.09.013

Note: The trial lasted only 8 weeks Can anticipate even better results for trials lasting 12-24 weeks Overview Diabetes and vitamin D contains the following {include} which also includes Diabetic Epidemic {include} Kidney * Every child with kidney problems (ideopathic nephrotic syndrome) had low vitamin D – Oct 2015 * Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017 * Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016 * Diabetic Nephropathy – active vitamin D helps – Dec 2014 * Blacks have 4X more Kidney disease than whites – probably due to low vitamin D – March 2015 * Diabetic neuropathy least likely if have 30-40 ng of vitamin D – Oct 2015 1. Items in both categories Diabetes and Kidney are listed here {category} --- 1. Overview Diabetes and vitamin D contains the following summary {include} --- 1. Diabetes category starts with the following {include} --- 1. Images from the web

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Metabolic and Inflammatory parameters.

Aims

Diabetic nephropathy is known to be an independent risk factor in the progression of renal and cardiovascular disorders. Due to the association between vitamin D deficiency and diabetic nephropathy, vitamin D deficiency in the diabetic nephropathy population, this study conducted to examine the effects of Vitamin D3 on metabolic and inflammatory parameters in patients with diabetic nephropathy.

Methods

This eight-week, randomized, double-blind, placebo-controlled trial was carried out on 50 diabetic nephropathy patients with marginal status of vitamin D. Participants were randomly assigned to two groups: control and intervention. Participants received a vitamin D3 (50000 IU) supplement weekly on a specific day. Fasting blood samples were collected from all patients at their entry to the study, and eight weeks after intervention.

Results

Analyses showed significance differences in physical activity between the intervention and placebo groups (P = 0.018). There were no significant differences between the percentage changes of HbA1c, insulin and, inflammatory parameters such as TNF-α and IL-6 (P > 0.05), while the percentage change of FBS was significantly higher in the placebo group compared to the treatment one (P < 0.0001). Lower levels of FBS (P < 0.0001), insulin (P < 0.069), HOMA-IR (P < 0.001), TNF-α (P< 0.002) and IL-6 (P < 0.037) were found after supplementation in treatment group. However, the phosphorous and protein percentage change in urine were lower (P = 0.07) and higher (P = 0.003) between groups.

Conclusions

It was found that vitamin D supplementation can be regarded as an effective way to prevent the progression of diabetic nephropathy by reducing levels of proteinuria, and inflammatory markers such as TNF-α and IL-6.

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Study was cited by 23 later studies as of Aug 2022

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