Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D

Created July 2016

How do autoimmune diseases cluster in families? A systematic review and meta-analysis - 2013

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Vertical axis = what you have, Horizonal axis = what relatives have

Figure 8 Familial autoimmunity. The vertical axis corresponds to the proband’s disease and each disease individually. In the horizontal axis diseases present in first degree relatives are shown. Each color belongs to the proband’s disease. The figure only includes significant results and may serve as a guide for clinical practice in order to search ADs in FDRs of probands. Note that familial autoimmune disease is excluded.

Most of the following diseases have studies on VitaminDWiki, only a few hyperlinks have been made


AA, alopecia areata;	AdD, Addison’s disease;	AS, ankylosing spondylitis	AITD, autoimmune thyroid disease
CD, celiac disease;	CrD, Crohn’s disease;	FDR, first degree relative;	IBD, inflammatory bowel disease
IIM, idiopathic inflammatory myositis;	JDM, juvenile dermatomyositis;	JRA, juvenilerheumatoid arthritis;	JSLE, juvenile systemic lupus erythematosus;
MAS, multiple autoimmune syndrome;	MG, myasthenia gravis;	MS, multiple sclerosis	PA, pernicious anemia;
PAN, polyarteritis nodosa;	PBC, primary biliary cirrhosis;	PSO, psoriasis;	RA, rheumatoid arthritis
SLE, systemic lupus erythematosus	SS, Sjögren’s syndrome;	SSc, systemic sclerosis;	T1D, type 1 diabetes;
UC, ulcerative colitis	VIT, vitiligo	WG, Wegener’s granulomatosis.

* Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014 * 1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Aug 2013 * Autoimmunity and Optimal Vitamin-D – Stochastic Chemical Dynamic correlation – June 2014 * How UVB reduces autoimmune diseases such as Multiple Sclerosis – April 2014 * 43 reasons for Vitamin D deficiency 20 of the reasons are new * Health problems that run in families are often associated with low vitamin D * Diseases that may be related via low vitamin D * Chance of having more than one disease (multimorbidity) up 34 percent if low vitamin D – Sept 2015 * One autoimmune disease lowers vitamin D, a second AI disease does not lower it further – Jan 2015 * Autoimmune **category listing has items along with related searches**

Do Autoimmune Diseases Run in Families? HealthCentral 2013 reporting on the study
- " . . autoimmune diseases which tend to cluster (aggregate) in our families."
- "Familial autoimmunity was investigated in five major autoimmune diseases: rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis, and type 1 diabetes mellitus. "
- Example: familial autoimmunity in Graves’ disease 14 X more likely to have family members to have pernicious anemia or RA
This study was cited by 65 other publications in Google Scholar as of Jan 2017 such as:
Hashimoto thyroiditis: clinical and diagnostic criteria
Diagnosis and classification of autoimmune diabetes mellitus
Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE
Systemic sclerosis at the crossroad of polyautoimmunity
New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease
The diagnosis and clinical significance of polyautoimmunity
Is narcolepsy a classical autoimmune disease?
Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)
Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis and type I diabetes
Prevalence of celiac disease in Latin America: A systematic review and meta-regression

Many autoimmune disease have increased recently - while vitamin D has decreased


Diabetes age-adjusted	Diabetes (CDC)
Multiple Sclerosis 70 %	Metabolic Syndrome 250 %
Ulcerative Colitis 210 %	Crohn's Disease

Tags: Autoimmune