Alzheimer's proven to be prevented and treated - RCT 2026
RCT preprint Jan 2026
Video = 62 minutes
The latest results from a randomized controlled trial (RCT) involving Dr. Dale Bredesen’s precision medicine protocol represent a significant breakthrough in Alzheimer's treatment, demonstrating sustained cognitive improvement rather than the mere slowing of decline.
Summary of Clinical Trial Results
(00:00 - 01:26) Dr. Bredesen introduces the results of a three-year randomized controlled trial, describing the findings as "absolutely striking" and more effective than any previously published data in the field of cognitive decline.
(01:26 - 03:06) Unlike first-generation drugs like Aricept—which may show mild initial improvement but often lead to worse long-term outcomes than no treatment—this precision medicine protocol focuses on addressing the underlying drivers of the disease for sustainable recovery.
(04:38 - 06:06) The nine-month trial was conducted across six sites, comparing patients on the personalized protocol to a "standard of care" control group. It specifically targeted individuals with Mild Cognitive Impairment (MCI) or early-stage dementia.
(06:34 - 07:17) Treatment group participants saw statistically significant improvements in overall cognition, memory, executive function, and processing speed. This contrasts with the control group, which continued to decline cognitively over the same period.[1]
(07:57 - 10:02) In certain sites, 100% of treated patients showed improvement, with many reaching the "completely normal" range for their age. Case studies also revealed significant physical improvements, such as the resolution of joint pain and autoimmune symptoms.
(10:36 - 11:12) Beyond cognition, the trial documented physiological benefits, including improvements in BMI, blood pressure, hemoglobin A1C, and lipid profiles, proving that the brain's health is intrinsically linked to the body’s metabolic state.
(11:38 - 13:13) Success was heavily tied to protocol compliance, which included achieving ketosis (ketone levels between 1.0–4.0), high-intensity interval exercise, and professional health coaching to ensure sustainable lifestyle changes.
(17:22 - 19:02) The protocol emphasizes the critical role of bioidentical hormone replacement therapy (BHRT), particularly topical estradiol and progesterone, in supporting brain health for menopausal women.
(15:06 - 16:35) Researchers noted the "ethics of waiting," as control group participants who delayed treatment by just nine months did not improve as rapidly or as thoroughly as those who began the active treatment protocol immediately.
(42:48 - 50:11) A core focus of the treatment involves identifying and targeting "root causes," such as chronic infections (e.g., HSV-1, Lyme disease) and biotoxins like mold or heavy metals, which often trigger the brain's protective amyloid response.
Insight: Dr. Bredesen often uses the "roof with 36 holes" analogy to explain this functional medicine approach: Alzheimer's is not caused by one single factor but by multiple metabolic imbalances. To successfully "fix the roof," one must address as many of these "holes" (risk factors) as possible simultaneously through personalized interventions (Apollo Health).
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Personalized protocol: Vitamin D, Omega-3, Exercise, Diet, Liposomal Glutathione, Sleep . . .
Curcumin Ashwagandha Bacopa moniera Gotu kola, Other herbs as indicated Magnesium threonate Ubiquinol PQQ Resveratrol Nicotinamide riboside Omega-3: EPA & DHA Choline Liposomal glutathione Probiotics and prebiotics Vitamin D3 and K2 (MK7) Methylcobalamin, methylfolate, P5P ALA, NAC, cinnamon, berberine or metormin Zinc picolonate, ALA, NAC, P5P, Mn, vitamin C