Vitamin D and Immune Function – Review July 2013

Nutrients 2013, 5(7), 2502-2521; doi:10.3390/nu5072502 (doi registration under processing)
Barbara Prietlemail, Gerlies Treiberemail, Thomas R. Pieberemail and Karin Amrein karin.amrein@medunigraz.at
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
(This article belongs to the Special Issue Nutrients and Immune Function)

Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types including various immune cells such as antigen-presenting-cells, T cells, B cells and monocytes. In vitro data show that, in addition to modulating innate immune cells, vitamin D also promotes a more tolerogenic immunological status. In vivo data from animals and from human vitamin D supplementation studies have shown beneficial effects of vitamin D on immune function, in particular in the context of autoimmunity. In this review, currently available data are summarized to give an overview of the effects of vitamin D on the immune system in general and on the regulation of inflammatory responses, as well as regulatory mechanisms connected to autoimmune diseases particularly in type 1 diabetes mellitus.

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Type 1 Diabetes - variety of forms of vitamin D

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Possible vitamin D interaction with T cells

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Vitamin D treatments for kidney

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