Proc Nutr Soc. 2011 Aug 18:1-12.
UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, David Geffen School of Medicine at UCLA, 615 Charles E. Young, Los Angeles, CA 90095, USA.
Immunomodulatory actions of vitamin D have been recognised for over a quarter of a century, but it is only in the last few years that the significance of this to normal human physiology has become apparent. Two key factors have underpinned this revised perspective. Firstly, there are increasing data linking vitamin insufficiency with prevalent immune disorders. Improved awareness of low circulating levels of precursor 25-hydroxyvitamin D in populations across the globe has prompted epidemiological investigations of health problems associated with vitamin D insufficiency. Prominent among these are autoimmune diseases such as multiple sclerosis, type 1 diabetes and Crohn's disease, but more recent studies indicate that infections such as tuberculosis may also be linked to low 25-hydroxyvitamin D levels. The second factor expanding the link between vitamin D and the immune system is our improved knowledge of the mechanisms that facilitate this association.
It is now clear that cells from the immune system contain all the machinery needed to convert 25-hydroxyvitamin D to active 1,25-dihydroxyvitamin D, and for subsequent responses to 1,25-dihydroxyvitamin D. Mechanisms such as this are important for promoting antimicrobial responses to pathogens in macrophages, and for regulating the maturation of antigen-presenting dendritic cells. The latter may be a key pathway by which vitamin D controls T-lymphocyte (T-cell) function.
However, T-cells also exhibit direct responses to 1,25-dihydroxyvitamin D, notably the development of suppressor regulatory T-cells.
Collectively these observations suggest that vitamin D is a key factor linking innate and adaptive immunity, and both of these functions may be compromised under conditions of vitamin D insufficiency.
- Fight Cancer with more than cut, burn, and poison – Nobel prize for T-Cell – Oct 2018
- Autoimmunity, T Cells and vitamin D: A chemical network analysis – May 2013
- All items in Immunity and Vitamin D
- Search VitaminDWiki for T-cell 1180 hits as of Sept 2014
- Overview Influenza and vitamin D
- Overview Tuberculosis and Vitamin D
- Overview Cancer and vitamin D
- Vitamin D is a T-cell modulator in multiple sclerosis – April 2011.
- Yet again - more than 10000 IU of vitamin D treats MS – July 2011 T-cell
- The vitamin D receptor and T cell function – June 2013
- Autoimmune diseases and over-active T cells (which are deactivated by vitamin D) – March 2014
- Vitamin D improves T Cell immunity – RCT Feb 2016
- Vitamin D and Immune Function – Review July 2013 which has the following chart
Vitamin D helps T-cell and immune system – overview Aug 2011
- Seasonal variation in vitamin d(3) levels is paralleled by changes in the peripheral blood human T cell compartment 2012 full text on-line
6090 visitors, last modified 22 Oct, 2018,