Probiotics reduces blood pressure, but not as much as vitamin D does – meta-analysis July 2014

Effect of Probiotics on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials

HYPERTENSIONAHA.114.03469, Published online before print July 21, 2014,
doi: 10.1161/​ Saman Khalesi, Jing Sun, Nicholas Buys, Rohan Jayasinghe
From the Griffith Health Institute (S.K., J.S., N.B.) and School of Medicine (S.K., J.S., R.J.), Griffith University, Australia; and Australia and Cardiac Services/Cardiology, Gold Coast Health, Australia (R.J.)
Correspondence to Jing Sun, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast Campus, Parkland, Gold Coast, Queensland 4222, Australia. E-mail

Previous human clinical trials have shown that probiotic consumption may improve blood pressure (BP) control. The aim of the present systematic review was to clarify the effects of probiotics on BP using a meta-analysis of randomized, controlled trials. PubMed, Scopus, Cochrane Library (Central), Physiotherapy Evidence Database, and databases were searched until January 2014 to identify eligible articles. Meta-analysis using a random-effects model was chosen to analyze the impact of combined trials. Nine trials were included. Probiotic consumption significantly changed

  • systolic BP by −3.56 mm Hg (95% confidence interval, −6.46 to −0.66) and
  • diastolic BP by −2.38 mm Hg (95% confidence interval, −2.38 to −0.93)

compared with control groups. A greater reduction was found with multiple as compared with single species of probiotics, for both systolic and diastolic BP. Subgroup analysis of trials with baseline BP ≥130/85 mm Hg compared with <130/85 mm Hg found a more significant improvement in diastolic BP. Duration of intervention <8 weeks did not result in a significant reduction in systolic or diastolic BP. Furthermore, subgroup analysis of trials with daily dose of probiotics <1011 colony-forming units did not result in a significant meta-analysis effect. The present meta-analysis suggests that consuming probiotics may improve BP by a modest degree, with a potentially greater effect when baseline BP is elevated, multiple species of probiotics are consumed, the duration of intervention is ≥8 weeks, or daily consumption dose is ≥1011 colony-forming units.

VitaminDWiki observations

Yes - expect to have a bigger effect for higher blood pressure levels
Yes - expect to have a bigger effect if > 8 weeks
Yes - expect to have a bigger effect if use the right probiotic (there are a many available)
Probably have a bigger effect depending on when the probitotic is taken, and with what food
Probably have a bigger effect if person had not taken an antibiotic in past 6 months
Most likely have a very large effect if take right probiotic at right time of the day & high level of vitamin D & no recent antibiotic

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