Prognostic value of vitamin D in patients with pneumonia: A systematic review and meta-analysis
Tropical Journal of Pharmaceutical Research September 2017; 16 (9): 2267-2273
Yu mei Wang1, Chen ling Tang2, Ming Che2*, Xiu qin Wang2 and Ai chun Li2
1 Management Office of Hospital Infection,
2 Department of Tuberculosis Internal Medicine, The Chest Hospital of Linyi, Linyi City, Shandong Province, 276034, China
For correspondence: Email: go0654@163.com
- Pneumonia and low vitamin D - many studies
- Pneumonia acquired in hospital – 3X more likely to die if low vitamin D – June 2015
- Severe Pneumonia (CAP) results in death 2 times more often if very low vitamin D – July 2016
- Viral Pneumonia in children 52 X more-likely if very low vitamin D (trend) – June 2017
- Pneumonia in seniors was 2.5X more likely if low vitamin D – June 2014
- ICU patients with pneumonia stay 7 days longer if low vitamin D - Dec 2011
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Purpose: To investigate the prognostic role of vitamin D in pneumonia patients through meta-analysis.
Methods: PubMed and Embase were systematically searched for relevant studies that assessed the impact of vitamin D on the risk of adverse outcomes among patients with pneumonia. Risk ratios (RR) with 95 % confidence intervals (95 % CI) were pooled using meta-analysis. Q-test and I2 statistics were used to evaluate between-study heterogeneity.
Results: Six studies were finally included in the meta-analysis. The results of meta-analysis of these studies indicated that low vitamin D status was associated with higher risk of mortality among pneumonia patients (RR = 2.59, 95 % CI = 1.32-5.08; p = 0.005). Results from meta-analysis of studies with adjusted estimates suggest that low vitamin D status was independently associated with higher risk of mortality among pneumonia patients (RR = 3.15, 95 % CI 1.54-6.44, p = 0.002). There was no significant risk of bias in the meta-analysis.
Conclusion: This study demonstrates that low vitamin D level is associated with a higher risk of adverse outcomes in patients with pneumonia.