Int J Clin Pharmacol Ther. 2018 Aug 6. doi: 10.5414/CP203252. [Epub ahead of print]
Abdul-Razzak KK, Mayyas FA, Al-Farras MI.
- Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
- Note: Magnesium also decreases both depression and musculoskeletal pain
Pain - chronic category has the following
- Overview Pain and Vitamin D
- Percentage of people with pain increased 25 percent in 18 years – Jan 2019
- Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
- Overview Fibromyalgia or Chronic Fatigue and vitamin D
- Overview Rheumatoid Arthritis and vitamin D
- Shingles and vitamin D
- Shin splints decrease with vitamin D
- Migraine and Vitamin D
- Headache category
- "musculoskeletal pain" 490 items as of Aug 2023
- "chronic fatigue" 185 items as of Jan 2017
- Category Back Pain
- 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
- Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021
Items in both categories PAIN and DEPRESSION are listed here:
To determine the incidence of vitamin D deficiency, anxiety, and depression disorders in an outpatient population with musculoskeletal pain (MSP), and to evaluate the effects of correcting a vitamin D deficiency on MSP and psychological symptoms.
MATERIALS AND METHODS:
A total of 261 outpatients with MSP and 100 controls were involved. The Hospital Anxiety and Depression Scale (HADS) was used to assess psychological symptoms. Serum vitamin D was measured. Outpatients with vitamin D insufficiency and deficiency received oral vitamin D supplementation. Pain severity and psychological symptoms were evaluated before and after vitamin D supplementation plus dairy products.
Vitamin D deficiency was found in 88.7% of participants in the MSP group and 69% of controls. Clinical anxiety was reported by 38.3% of participants in the MSP group and 9% of controls, while clinical depression was reported by 31.8% of participants in the MSP group and 2% of controls.
Multisite pain was significantly and positively associated with anxiety, depression, and pain severity, and was inversely associated with daily calcium intake.
Anxiety was inversely associated with vitamin D level, daily calcium intake, and age. A similar pattern was observed for depression. MSP was the most significant independent predictor of anxiety (OR = 7.84) and depression (OR = 5.89). Relative to baseline, all measured outcome parameters significantly improved after vitamin D supplementation plus increased intake of dairy products.
Low serum vitamin D is associated with MSP along with low calcium intake, depression, and anxiety. Supplementation with vitamin D improved MSP and associated disorders. .