Dogs and Cats still need vitamin D – July 2021

Vitamin D metabolism and disorders in dogs and cats

J Small Anim Pract. 2021 Jul 29. doi: 10.1111/jsap.13401
K E Clarke 1, E A Hurst 2, R J Mellanby 2

Vitamin D plays an important role in regulating calcium metabolism and in the development and maintenance of skeletal health of companion animals. There is also a growing interest in understanding the role vitamin D plays in non-skeletal health in both human and veterinary patients. This review provides an update of our current understanding of vitamin D biology in dogs and cats and gives an overview of how vitamin D metabolism can be assessed in companion animals. Congenital and acquired vitamin D disorders are then summarised before the review concludes with a summary of recent studies which have explored the role of vitamin D in the development and outcomes of non-skeletal diseases of dogs and cats.

VitaminDWiki

Overview Veterinary and vitamin D has the following

Veterinary category has 151 items

Animals need Vitamin D too

Pets as well

Farm Vets are paid when their "patients" are healthy,
   vs doctors who are paid only when "patients" become sick

Cows are routinely given 30 IU per kilogram (which would be 10,000 IU for a 150 lb person)
Same information is available on Cattle need 66 IU of vitamin D per pound
The US RDA of vitamin D for cows is 13 IU per kilogram (which would be 4,300 IU for a 150 lb 'cow')
Virtually all US farmers who raise livestock use feed that is supplemented with vitamin D
Merick Vet Manual supplement if not have UV or sunlight

PDF is behind a paywall

References (dog, cat, and human)

  • Adamany, J. L. & Dhumeaux, M. P. (2016) Hypercalcaemia secondary to elevated 1,25 dihydroxycholecalciferol in a dog with immune-mediated polyarthritis. The Journal of Small Animal Practice 57, 323-326. https://doi.org/10.1111/jsap.12434
  • Adams, J. S. & Hewison, M. (2012) Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Archives of Biochemistry and Biophysics 523, 95-102. https://doi.org/10.1016/j.abb.2012.02.016
  • Allenspach, K., Rizzo, J., Jergens, A. E., et al. (2017) Hypovitaminosis D is associated with negative outcome in dogs with protein losing enteropathy: a retrospective study of 43 cases. BMC Veterinary Research 13, 96. https://doi.org/10.1186/s12917-017-1022-7
  • Altieri, B., Cavalier, E., Bhattoa, H. P., et al. (2020) Vitamin D testing: advantages and limits of the current assays. European Journal of Clinical Nutrition 74, 231-247. https://doi.org/10.1038/s41430-019-0553-3
  • Al-Zohily, B., Al-Menhali, A., Gariballa, S., et al. (2020) Epimers of vitamin D: a review. International Journal of Molecular Sciences 21, 513-515. https://doi.org/10.3390/ijms21020470
  • Ananthakrishnan, A. N. (2016) Vitamin D and inflammatory bowel disease. Gastroenterology and Hepatology 12(8), 513-515
  • Astecker, N., Reddy, G. S., Herzig, G., et al. (2000) 1alpha,25-Dihydroxy-3-epi-vitamin D3 a physiological metabolite of 1alpha,25-dihydroxyvitamin D3: its production and metabolism in primary human keratinocytes. Molecular and Cellular Endocrinology 170, 91-101. https://doi.org/10.1016/s0303-7207(00)00330-0
  • Bailey, D., Veljkovic, K., Yazdanpanah, M., et al. (2013) Analytical measurement and clinical relevance of vitamin D(3) C3-epimer. Clinical Biochemistry 46, 190-196. https://doi.org/10.1016/j.clinbiochem.2012.10.037
  • Bang, U. C., Novovic, S., Andersen, A. M., et al. (2011) Variations in serum 25-hydroxyvitamin D during acute pancreatitis: an exploratory longitudinal study. Endocrine Research 36, 135-141. https://doi.org/10.3109/07435800.2011.554937
  • Baral, R. M., Metcalfe, S. S., Krockenberger, M. B., et al. (2006) Disseminated Mycobacterium avium infection in young cats: overrepresentation of Abyssinian cats. Journal of Feline Medicine and Surgery 8, 23-44. https://doi.org/10.1016/j.jfms.2005.06.004
  • Barber, P. J. & Elliott, J. (1998) Feline chronic renal failure: calcium homeostasis in 80 cases diagnosed between 1992 and 1995. The Journal of Small Animal Practice 39, 108-116
  • Barko, P. C. & Williams, D. A. (2018) Serum concentrations of lipid-soluble vitamins in dogs with exocrine pancreatic insufficiency treated with pancreatic enzymes. Journal of Veterinary Internal Medicine 32, 1600-1608. https://doi.org/10.1111/jvim.15292
  • Beckman, M. J., Tadikonda, P., Werner, E., et al. (1996) Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme. Biochemistry 35, 8465-8472. https://doi.org/10.1021/bi960658i
  • Bikle, D. D. (2014) Vitamin D metabolism, mechanism of action, and clinical applications. Chemistry & Biology 21, 319-329. https://doi.org/10.1016/j.chembiol.2013.12.016
  • Bikle, D. D. (2018) Vitamin D Assays. Frontiers of Hormone Research 50, 14-30. https://doi.org/10.1159/000486062
  • Bikle, D. D., Gee, E., Halloran, B., et al. (1986) Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. The Journal of Clinical Endocrinology and Metabolism 63, 954-959. https://doi.org/10.1210/jcem-63-4-954
  • Bikle, D. D., Malmstroem, S. & Schwartz, J. (2017) Current controversies: are free vitamin metabolite levels a more accurate assessment of vitamin D status than total levels? Endocrinology and Metabolism Clinics of North America 46, 901-918. https://doi.org/10.1016/j.ecl.2017.07.013
  • Bilezikian, J. P., Bikle, D., Hewison, M., et al. (2020) MEchanisms in endocrinology: vitamin D and COVID-19. European Journal of Endocrinology 183, R133-R147. https://doi.org/10.1530/EJE-20-0665
  • Binkley, N., Dawson-Hughes, B., Durazo-Arvizu, R., et al. (2017) Vitamin D measurement standardization: the way out of the chaos. The Journal of Steroid Biochemistry and Molecular Biology 173, 117-121. https://doi.org/10.1016/j.jsbmb.2016.12.002
  • Bischoff, K. & Rumbeiha, W. K. (2018) Pet food recalls and pet food contaminants in small animals: an update. The Veterinary Clinics of North America. Small Animal Practice 48, 917-931. https://doi.org/10.1016/j.cvsm.2018.07.005
  • Boag, A. K., Murphy, K. F. & Connolly, D. J. (2005) Hypercalcaemia associated with angiostrongylus vasorum in three dogs. The Journal of Small Animal Practice 46, 79-84
  • Boyan, B. D., Hurst-Kennedy, J., Denison, T. A., et al. (2010) 24R,25-dihydroxyvitamin D3 24R,25(OH)2D3 controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells. The Journal of Steroid Biochemistry and Molecular Biology 121, 212-216. https://doi.org/10.1016/j.jsbmb.2010.03.057
  • Boyan, B. D., Hyzy, S. L., Pan, Q., et al. (2016) 24R,25-Dihydroxyvitamin D3 protects against articular cartilage damage following anterior cruciate ligament transection in male rats. PLoS One 11, e0161782. https://doi.org/10.1371/journal.pone.0161782
  • Boyle, I. T., Gray, R. W. & DeLuca, H. F. (1971) Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol. Proceedings of the National Academy of Sciences of the United States of America 68, 2131-2134. https://doi.org/10.1073/pnas.68.9.2131
  • Brenza, H. L. & DeLuca, H. F. (2000) Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Archives of Biochemistry and Biophysics 381, 143-152. https://doi.org/10.1006/abbi.2000.1970
  • Brown, A. J., Ritter, C. S., Weiskopf, A. S., et al. (2005) Isolation and identification of 1alpha-hydroxy-3-epi-vitamin D3, a potent suppressor of parathyroid hormone secretion. Journal of Cellular Biochemistry 96, 569-578. https://doi.org/10.1002/jcb.20553
  • Carter, G. D., Berry, J., Durazo-Arvizu, R., et al. (2018) Hydroxyvitamin D assays: an historical perspective from DEQAS. The Journal of Steroid Biochemistry and Molecular Biology 177, 30-35. https://doi.org/10.1016/j.jsbmb.2017.07.018
  • Cartwright, J. A., Gow, A. G., Milne, E., et al. (2018) Vitamin D receptor expression in dogs. Journal of Veterinary Internal Medicine 32, 764-774. https://doi.org/10.1111/jvim.15052
  • Cazzolli, D. M., Prittie, J. E., Fox, P. R., et al. (2019) Evaluation of serum 25-hydroxyvitamin D concentrations in a heterogeneous canine ICU population. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex.) 29, 605-610. https://doi.org/10.1111/vec.12901
  • Cheng, J. B., Levine, M. A., Bell, N. H., et al. (2004) Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proceedings of the National Academy of Sciences of the United States of America 101, 7711-7715. https://doi.org/10.1073/pnas.0402490101
  • Christakos, S., Dhawan, P., Verstuyf, A., et al. (2016) Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological Reviews 96, 365-408. https://doi.org/10.1152/physrev.00014.2015
  • Clements, D. N., Bruce, G., Ryan, J. M., et al. (2020) Effects of surgery on free and total 25 hydroxyvitamin D concentrations in dogs. Journal of Veterinary Internal Medicine 34, 2617-2621. https://doi.org/10.1111/jvim.15933
  • Cortadellas, O., Fernandez del Palacio, M. J., Talavera, J., et al. (2010) Calcium and phosphorus homeostasis in dogs with spontaneous chronic kidney disease at different stages of severity. Journal of Veterinary Internal Medicine 24, 73-79. https://doi.org/10.1111/j.1939-1676.2009.0415.x
  • Cortinovis, C., Pizzo, F. & Caloni, F. (2015) Poisoning of dogs and cats by drugs intended for human use. Veterinary Journal 203, 52-58. https://doi.org/10.1016/j.tvjl.2014.11.004
  • Couchman, L. & Moniz, C. F. (2017) Analytical considerations for the biochemical assessment of vitamin D status. Therapeutic Advances in Musculoskeletal Disease 9, 97-104. https://doi.org/10.1177/1759720X17692500
  • Crossley, V. J., Bovens, C. P., Pineda, C., et al. (2017) Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food. JFMS Open Reports 3, 2055116917743613. https://doi.org/10.1177/2055116917743613
  • Davies, N. M., Holmes, M. V. & Davey Smith, G. (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362, k601. https://doi.org/10.1136/bmj.k601
  • de Brito Galvao, J. F., Nagode, L. A., Schenck, P. A., et al. (2013) Calcitriol, calcidiol, parathyroid hormone, and fibroblast growth factor-23 interactions in chronic kidney disease. Journal of Veterinary Emergency and Critical Care (San Antonio, Tex.) 23, 134-162. https://doi.org/10.1111/vec.12036
  • DeClementi, C. & Sobczak, B. R. (2018) Common rodenticide toxicoses in small animals. The Veterinary Clinics of North America. Small Animal Practice 48, 1027-1038. https://doi.org/10.1016/j.cvsm.2018.06.006
  • Dirks, N. F., Ackermans, M. T., Lips, P., et al. (2018) The when, what & how of measuring vitamin D metabolism in clinical medicine. Nutrients 10, 482. https://doi.org/10.3390/nu10040482
  • Dittmer, K. E. & Thompson, K. G. (2011) Vitamin D metabolism and rickets in domestic animals: a review. Veterinary Pathology 48, 389-407. https://doi.org/10.1177/0300985810375240
  • Dodd, S., Barry, M., Grant, C., et al. (2019) Abnormal bone mineralization in a puppy fed an imbalanced raw meat homemade diet diagnosed and monitored using dual-energy X-ray absorptiometry. Journal of Animal Physiology and Animal Nutrition 1-8
  • Durazo-Arvizu, R. A., Ahmed, F., Berry, J., et al. (2019) Estimating uncertainty of target values for DEQAS serum materials. The Journal of Steroid Biochemistry and Molecular Biology 188, 90-94. https://doi.org/10.1016/j.jsbmb.2018.12.011
  • Dvir, E., Rosa, C., Handel, I., et al. (2019) Vitamin D status in dogs with babesiosis. The Onderstepoort Journal of Veterinary Research 86, e1-e5. https://doi.org/10.4102/ojvr.v86i1.1644
  • Edwards, D. F. & Russell, R. G. (1987) Probable vitamin K - deficient bleeding in two cats with malabsorption syndrome secondary to lymphocytic-plasmacytic enteritis. Journal of Veterinary Internal Medicine 1, 97-101
  • Elder, C. J. & Bishop, N. J. (2014) Rickets. Lancet 383, 1665-1676. https://doi.org/10.1016/S0140-6736(13)61650-5
  • Fan, T. M., Simpson, K. W., Trasti, S., et al. (1998) Calcipotriol toxicity in a dog. The Journal of Small Animal Practice 39, 581-586. https://doi.org/10.1111/j.1748-5827.1998.tb03712.x
  • Fernando, M., Ellery, S. J., Marquina, C., et al. (2020) Vitamin D-binding protein in pregnancy and reproductive health. Nutrients 12, 1489. https://doi.org/10.3390/nu12051489
  • Fleet, J. C., Bradley, J., Reddy, G. S., et al. (1996) 1 alpha,25-(OH)2-vitamin D3 analogs with minimal in vivo calcemic activity can stimulate significant transepithelial calcium transport and mRNA expression in vitro. Archives of Biochemistry and Biophysics 329, 228-234. https://doi.org/10.1006/abbi.1996.0213
  • Freeman, L. M. & Michel, K. E. (2001) Evaluation of raw food diets for dogs. Journal of the American Veterinary Medical Association 218, 705-709. https://doi.org/10.2460/javma.2001.218.705
  • Fritz, C. A., Navetta, K. A., Wolford, D. P., et al. (2017) Assessment of endogenous 25-hydroxyvitamin D serum concentrations by liquid chromatography-tandem mass spectrometry in various animal species. Veterinary Clinical Pathology 46, 371-379. https://doi.org/10.1111/vcp.12476
  • Fujita, Y., Hanazono, K., Uchida, E., et al. (2017) Renal failure in dogs kept by a man with severe psoriasis. Journal of the European Academy of Dermatology and Venereology 31, e184-e185. https://doi.org/10.1111/jdv.13908
  • Galler, A., Tran, J. L., Krammer-Lukas, S., et al. (2012) Blood vitamin levels in dogs with chronic kidney disease. Veterinary Journal 192, 226-231. https://doi.org/10.1016/j.tvjl.2011.06.026
  • Garg, U. (2018) 25-Hydroxyvitamin D testing: immunoassays versus tandem mass spectrometry. Clinics in Laboratory Medicine 38, 439-453. https://doi.org/10.1016/j.cll.2018.05.007
  • Geisen, V., Weber, K. & Hartmann, K. (2009) Vitamin D-dependent hereditary rickets type I in a cat. Journal of Veterinary Internal Medicine 23, 196-199. https://doi.org/10.1111/j.1939-1676.2008.00220.x
  • Gerhard, C. & Jaffey, J. A. (2019) Persistent increase in serum 25-Hydroxyvitamin D concentration in a dog following cholecalciferol intoxication. Frontiers in Veterinary Science 6, 472. https://doi.org/10.3389/fvets.2019.00472
  • Godfrey, D. R., Anderson, R. M., Barber, P. J., et al. (2005) Vitamin D-dependent rickets type II in a cat. The Journal of Small Animal Practice 46, 440-444. https://doi.org/10.1111/j.1748-5827.2005.tb00343.x
  • Goodwin, L. V., Goggs, R., Chan, D. L., et al. (2011) Hypercoagulability in dogs with protein-losing enteropathy. Journal of Veterinary Internal Medicine 25, 273-277. https://doi.org/10.1111/j.1939-1676.2011.0683.x
  • Gow, A. G., Else, R., Evans, H., et al. (2011) Hypovitaminosis D in dogs with inflammatory bowel disease and hypoalbuminaemia. The Journal of Small Animal Practice 52, 411-418. https://doi.org/10.1111/j.1748-5827.2011.01082.x
  • Grahn, R. A., Ellis, M. R., Grahn, J. C., et al. (2012) A novel CYP27B1 mutation causes a feline vitamin D-dependent rickets type IA. Journal of Feline Medicine and Surgery 14, 587-590. https://doi.org/10.1177/1098612X12446637
  • Groth, E. M., Lulich, J. P., Chew, D. J., et al. (2019) Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis. Journal of Veterinary Internal Medicine 33, 758-763. https://doi.org/10.1111/jvim.15442
  • Gubatan, J. & Moss, A. C. (2018) Vitamin D in inflammatory bowel disease: more than just a supplement. Current Opinion in Gastroenterology 34, 217-225. https://doi.org/10.1097/MOG.0000000000000449
  • Hall, G., Breheny, C., Khan, Z., et al. (2020) Severe nutritional deficiencies and osteopenia in a dog fed a homemade raw diet. Veterinary Record Case Report 8, e001038
  • Haussler, M. R., Jurutka, P. W., Mizwicki, M., et al. (2011) Vitamin D receptor (VDR)-mediated actions of 1alpha,25(OH)(2)vitamin D(3): genomic and non-genomic mechanisms. Best Practice & Research. Clinical Endocrinology & Metabolism 25, 543-559. https://doi.org/10.1016/j.beem.2011.05.010
  • Herrmann, M., Farrell, C. L., Pusceddu, I., et al. (2017) Assessment of vitamin D status - a changing landscape. Clinical Chemistry and Laboratory Medicine 55, 3-26. https://doi.org/10.1515/cclm-2016-0264
  • Hewison, M., Burke, F., Evans, K. N., et al. (2007) Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. The Journal of Steroid Biochemistry and Molecular Biology 103, 316-321. https://doi.org/10.1016/j.jsbmb.2006.12.078
  • Ho, B., Ellison, J., Edwards, N., et al. (2020) Prevalence of vitamin D analogue toxicity in dogs. Clinical and Experimental Dermatology 46, 577-578. https://doi.org/10.1111/ced.14499
  • Hobi, S., Bettenay, S., Majzoub, M., et al. (2015) Mycobacterium avium subspecies hominissuis infection in a dog from Germany with multifocal alopecia, exfoliative dermatitis, hypercalcaemia and subsequent sebaceous atrophy. Veterinary Record Case Reports 3, e000168
  • Holick, M. F. (2007) Vitamin D deficiency. The New England Journal of Medicine 357, 266-281
  • Holowaychuk, M. K., Birkenheuer, A. J., Li, J., et al. (2012) Hypocalcemia and hypovitaminosis D in dogs with induced endotoxemia. Journal of Veterinary Internal Medicine 26, 244-251. https://doi.org/10.1111/j.1939-1676.2012.00886.x
  • Hostutler, R. A., Chew, D. J., Jaeger, J. Q., et al. (2005) Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia. Journal of Veterinary Internal Medicine 19, 29-33. https://doi.org/10.1892/0891-6640(2005)19<29:uaeopd>2.0.co;2
  • How, K. L., Hazewinkel, H. A. & Mol, J. A. (1994a) Dietary vitamin D dependence of cat and dog due to inadequate cutaneous synthesis of vitamin D. General and Comparative Endocrinology 96, 12-18. https://doi.org/10.1006/gcen.1994.1154
  • How, K. L., Hazewinkel, H. A. & Mol, J. A. (1994b) Photosynthesis of vitamin D3 in cats. The Veterinary Record 134, 384
  • How, K. L., Hazewinkel, H. A. & Mol, J. A. (1995) Photosynthesis of vitamin D in the skin of dogs cats and rats. The Veterinary Quarterly 17(Suppl 1), S29
  • Hurst, E. A., Homer, N. Z., Denham, S. G., et al. (2020a) Development and application of a LC-MS/MS assay for simultaneous analysis of 25-hydroxyvitamin-D and 3-epi-25-hydroxyvitamin-D metabolites in canine serum. The Journal of Steroid Biochemistry and Molecular Biology 199, 105598. https://doi.org/10.1016/j.jsbmb.2020.105598
  • Hurst, E. A., Homer, N. Z., Gow, A. G., et al. (2020b) Vitamin D status is seasonally stable in northern European dogs. Veterinary Clinical Pathology 49, 279-291. https://doi.org/10.1111/vcp.12859
  • Hutchinson, D., Freeman, L. M., McCarthy, R., et al. (2012) Seizures and severe nutrient deficiencies in a puppy fed a homemade diet. Journal of the American Veterinary Medical Association 241, 477-483. https://doi.org/10.2460/javma.241.4.477
  • Jacobs, G., Collins-Kelly, L., Lappin, M., et al. (1990) Lymphocytic-plasmacytic enteritis in 24 dogs. Journal of Veterinary Internal Medicine 4, 45-53
  • Jaffey, J. A., Backus, R. C., McDaniel, K. M., et al. (2018) Serum vitamin D concentrations in hospitalized critically ill dogs. PLoS One 13, e0194062. https://doi.org/10.1371/journal.pone.0194062
  • Jaffey, J. A., Amorim, J. & DeClue, A. E. (2018a) Effects of calcitriol on apoptosis, toll-like receptor 4 expression, and cytokine production of endotoxin-primed canine leukocytes. American Journal of Veterinary Research 79, 1071-1078. https://doi.org/10.2460/ajvr.79.10.1071
  • Jaffey, J. A., Amorim, J. & DeClue, A. E. (2018b) Effects of calcitriol on phagocytic function, toll-like receptor 4 expression, and cytokine production of canine leukocytes. American Journal of Veterinary Research 79, 1064-1070. https://doi.org/10.2460/ajvr.79.10.1064
  • Jaffey, J. A., Bessette, M., Tao, Z., et al. (2020) Effects of calcitriol on oxidative burst, phagocytic function, and leukocyte cytokine production in shelter dogs. Canine Medicine and Genetics 7, 11. https://doi.org/10.1186/s40575-020-00090-y
  • Jenkinson, C., Taylor, A. E., Hassan-Smith, Z. K., et al. (2016) High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 1014, 56-63. https://doi.org/10.1016/j.jchromb.2016.01.049
  • Jergens, A. E., Moore, F. M., Haynes, J. S., et al. (1992) Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987-1990). Journal of the American Veterinary Medical Association 201, 1603-1608
  • Jolliffe, D. A., Greenberg, L., Hooper, R. L., et al. (2019) Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials. Thorax 74, 337-345. https://doi.org/10.1136/thoraxjnl-2018-212092
  • Jones, G., Prosser, D. E. & Kaufmann, M. (2014) Cytochrome P450-mediated metabolism of vitamin D. Journal of Lipid Research 55, 13-31. https://doi.org/10.1194/jlr.R031534
  • Kaewsakhorn, T., Kisseberth, W. C., Capen, C. C., et al. (2005) Effects of calcitriol, seocalcitol, and medium-chain triglyceride on a canine transitional cell carcinoma cell line. Anticancer Research 25, 2689-2696
  • Kamao, M., Tatematsu, S., Reddy, G. S., et al. (2001) Isolation, identification and biological activity of 24R,25-dihydroxy-3-epi-vitamin D3: a novel metabolite of 24R,25-dihydroxyvitamin D3 produced in rat osteosarcoma cells (UMR 106). Journal of Nutritional Science and Vitaminology (Tokyo) 47, 108-115. https://doi.org/10.3177/jnsv.47.108
  • Kamao, M., Tatematsu, S., Hatakeyama, S., et al. (2004) C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation. The Journal of Biological Chemistry 279, 15897-15907. https://doi.org/10.1074/jbc.M311473200
  • Kellermann, L., Jensen, K. B., Bergenheim, F., et al. (2020) Mucosal vitamin D signaling in inflammatory bowel disease. Autoimmunity Reviews 19, 102672. https://doi.org/10.1016/j.autrev.2020.102672
  • Keum, N., Lee, D. H., Greenwood, D. C., et al. (2019) Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Annals of Oncology 30, 733-743. https://doi.org/10.1093/annonc/mdz059
  • Kibler, L., Heinze, C. R. & Webster, C. R. (2020) Serum vitamin D status in sick cats with and without cholestatic liver disease. Journal of Feline Medicine and Surgery 22, 944-952. https://doi.org/10.1177/1098612X19895081
  • Kim, D. I., Kim, H., Son, P., et al. (2017) Serum 25-hydroxyvitamin D concentrations in dogs with suspected acute pancreatitis. The Journal of Veterinary Medical Science 79, 1366-1373. https://doi.org/10.1292/jvms.16-0647
  • Kimmel, S. E., Waddell, L. S. & Michel, K. E. (2000) Hypomagnesemia and hypocalcemia associated with protein-losing enteropathy in Yorkshire terriers: five cases (1992-1998). Journal of the American Veterinary Medical Association 217, 703-706
  • Klinger, C. J., Hobi, S., Johansen, C., et al. (2018) Vitamin D shows in vivo efficacy in a placebo-controlled, double-blinded, randomised clinical trial on canine atopic dermatitis. The Veterinary Record 182, 406. https://doi.org/10.1136/vr.104492
  • Kovalik, M., Thoday, K. L., Berry, J., et al. (2012) Prednisolone therapy for atopic dermatitis is less effective in dogs with lower pretreatment serum 25-hydroxyvitamin D concentrations. Veterinary Dermatology 23, 125-130, e127-128. https://doi.org/10.1111/j.1365-3164.2011.01022.x
  • Kraus, M. S., Rassnick, K. M., Wakshlag, J. J., et al. (2014) Relation of vitamin d status to congestive heart failure and cardiovascular events in dogs. Journal of Veterinary Internal Medicine 28, 109-115. https://doi.org/10.1111/jvim.12239
  • Kritikos, G., Weidner, N., Atkinson, J. L., et al. (2018) Quantification of vitamin D3 in commercial dog foods and comparison with Association of American Feed Control Officials recommendations and manufacturer-reported concentrations. Journal of the American Veterinary Medical Association 252, 1521-1526. https://doi.org/10.2460/javma.252.12.1521
  • Kull, P. A., Hess, R. S., Craig, L. E., et al. (2001) Clinical, clinicopathologic, radiographic, and ultrasonographic characteristics of intestinal lymphangiectasia in dogs: 17 cases (1996-1998). Journal of the American Veterinary Medical Association 219, 197-202
  • Kunakornsawat, S., Rosol, T. J., Capen, C. C., et al. (2002) Effects of 1,25-dihydroxyvitamin D3 1,25(OH)2D3 and its analogues (EB1089 and analog V) on canine adenocarcinoma (CAC-8) in nude mice. Biological & Pharmaceutical Bulletin 25, 642-647
  • Kupferschmidt, K. (2012) Uncertain verdict as vitamin D goes on trial. Science 337, 1476-1478. https://doi.org/10.1126/science.337.6101.1476
  • Lalor, S. M., Mellanby, R. J., Friend, E. J., et al. (2012) Domesticated cats with active mycobacteria infections have low serum vitamin D (25(OH)D) concentrations. Transboundary and Emerging Diseases 59, 279-281. https://doi.org/10.1111/j.1865-1682.2011.01265.x
  • Lalor, S., Schwartz, A. M., Titmarsh, H., et al. (2014) Cats with inflammatory bowel disease and intestinal small cell lymphoma have low serum concentrations of 25-hydroxyvitamin D. Journal of Veterinary Internal Medicine 28, 351-355. https://doi.org/10.1111/jvim.12294
  • Larson, M. J., Oakes, A. B., Epperson, E., et al. (2019) Medication-related osteonecrosis of the jaw after long-term bisphosphonate treatment in a cat. Journal of Veterinary Internal Medicine 33, 862-867. https://doi.org/10.1111/jvim.15409
  • Laws, E. J., Kathrani, A., Harcourt-Brown, T. R., et al. (2018) 25-Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls. The Journal of Small Animal Practice 59, 222-227. https://doi.org/10.1111/jsap.12791
  • LeVine, D. N., Zhou, Y., Ghiloni, R. J., et al. (2009) Hereditary 1,25-dihydroxyvitamin D-resistant rickets in a Pomeranian dog caused by a novel mutation in the vitamin D receptor gene. Journal of Veterinary Internal Medicine 23, 1278-1283. https://doi.org/10.1111/j.1939-1676.2009.0405.x
  • Linde, K. J., Kelleher, T. R. & Perry, J. A. (2018) Biological implant-associated granulomatous inflammation resulting in secondary hypercalcemia and azotemia in a dog. Clinical Case Reports 6, 1801-1806. https://doi.org/10.1002/ccr3.1661
  • Lundberg, A. P., Roady, P. J., Somrak, A. J., et al. (2016) Zoledronate-associated osteonecrosis of the jaw in a dog with appendicular osteosarcoma. Journal of Veterinary Internal Medicine 30, 1235-1240. https://doi.org/10.1111/jvim.13980
  • Malik, R., Laing, C., Davis, P. E., et al. (1997) Rickets in a litter of racing greyhounds. The Journal of Small Animal Practice 38, 109-114
  • Manson, J. E., Bassuk, S. S., Buring, J. E., et al. (2019a) Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials. The Journal of Steroid Biochemistry and Molecular Biology 198, 105522. https://doi.org/10.1016/j.jsbmb.2019.105522
  • Manson, J. E., Cook, N. R., Lee, I. M., et al. (2019b) Vitamin D supplements and prevention of cancer and cardiovascular disease. The New England Journal of Medicine 380, 33-44. https://doi.org/10.1056/NEJMoa1809944
  • Martineau, A. R., Jolliffe, D. A., Hooper, R. L., et al. (2017) Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 356, i6583. https://doi.org/10.1136/bmj.i6583
  • Martineau, C., Naja, R. P., Husseini, A., et al. (2018) Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2. The Journal of Clinical Investigation 128, 3546-3557. https://doi.org/10.1172/JCI98093
  • Masuda, S., Kamao, M., Schroeder, N. J., et al. (2000) Characterization of 3-epi-1alpha,25-dihydroxyvitamin D3 involved in 1alpha,25-dihydroxyvitamin D3 metabolic pathway in cultured cell lines. Biological & Pharmaceutical Bulletin 23, 133-139. https://doi.org/10.1248/bpb.23.133
  • Mealey, K. L., Willard, M. D., Nagode, L. A., et al. (1999) Hypercalcemia associated with granulomatous disease in a cat. Journal of the American Veterinary Medical Association 215, 959-962 946
  • Mellanby, E. (1976) Nutrition classics. The Lancet 1:407-12, 1919. An experimental investigation of rickets. Edward Mellanby. Nutrition Reviews 34, 338-340
  • Mellanby, R. J. (2016) Beyond the skeleton: the role of vitamin D in companion animal health. The Journal of Small Animal Practice 57, 175-180. https://doi.org/10.1111/jsap.12458
  • Mellanby, R. J., Mee, A. P., Berry, J. L., et al. (2005a) Hypercalcaemia in two dogs caused by excessive dietary supplementation of vitamin D. The Journal of Small Animal Practice 46, 334-338
  • Mellanby, R. J., Mellor, P. J., Roulois, A., et al. (2005b) Hypocalcaemia associated with low serum vitamin D metabolite concentrations in two dogs with protein-losing enteropathies. The Journal of Small Animal Practice 46, 345-351
  • Mellanby, R. J., Mellor, P., Villiers, E. J., et al. (2006) Hypercalcaemia associated with granulomatous lymphadenitis and elevated 1,25 dihydroxyvitamin D concentration in a dog. The Journal of Small Animal Practice 47, 207-212. doi:JSAP19 pii. https://doi.org/10.1111/j.1748-5827.2006.00019.x
  • Mick, P. J., Peng, S. A. & Loftus, J. P. (2019) Serum vitamin D metabolites and CXCL10 concentrations associate with survival in dogs with immune mediated disease. Frontiers in Veterinary Science 6, 247. https://doi.org/10.3389/fvets.2019.00247
  • Miller, M. S., Rudinsky, A. J., Klamer, B. G., et al. (2020) Association between vitamin D metabolites, vitamin D binding protein, and proteinuria in dogs. Journal of Veterinary Internal Medicine 34, 2468-2477. https://doi.org/10.1111/jvim.15912
  • Mokry, L. E., Ross, S., Ahmad, O. S., et al. (2015) Vitamin D and risk of multiple sclerosis: a Mendelian randomization study. PLoS Medicine 12, e1001866. https://doi.org/10.1371/journal.pmed.1001866
  • Morita, T., Awakura, T., Shimada, A., et al. (1995) Vitamin D toxicosis in cats: natural outbreak and experimental study. The Journal of Veterinary Medical Science 57, 831-837
  • Morris, J. G. (1996a) Vitamin D synthesis by kittens. Veterinary Clinical Nutrition 3, 88-92
  • Morris, J. G. (1996b) Vitamin D and calcium requirements of kittens. Veterinary Clinical Nutrition 3, 93-96
  • Murayama, A., Takeyama, K., Kitanaka, S., et al. (1998) The promoter of the human 25-hydroxyvitamin D3 1 alpha-hydroxylase gene confers positive and negative responsiveness to PTH, calcitonin, and 1 alpha,25(OH)2D3. Biochemical and Biophysical Research Communications 249, 11-16. https://doi.org/10.1006/bbrc.1998.9098
  • Murayama, A., Takeyama, K., Kitanaka, S., et al. (1999) Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1alpha,25(OH)2D3 in intact animals. Endocrinology 140, 2224-2231. https://doi.org/10.1210/endo.140.5.6691
  • Nakagawa, K., Sowa, Y., Kurobe, M., et al. (2001) Differential activities of 1alpha,25-dihydroxy-16-ene-vitamin D(3) analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis. Steroids 66, 327-337. https://doi.org/10.1016/s0039-128x(00)00142-2
  • Nakamura, Y., Gotoh, M., Fukuo, Y., et al. (2004) Severe calcification of mucocutaneous and gastrointestinal tissues induced by high dose administration of vitamin D in a puppy. The Journal of Veterinary Medical Science 66, 1133-1135. https://doi.org/10.1292/jvms.66.1133
  • Nakamura, K., Tohyama, N., Yamasaki, M., et al. (2016) Hypercalcemia in a dog with chronic ingestion of maxacalcitol ointment. Journal of the American Animal Hospital Association 52, 256-258. https://doi.org/10.5326/JAAHA-MS-6286
  • Nonnecke, B. J., McGill, J. L., Ridpath, J. F., et al. (2014) Acute phase response elicited by experimental bovine diarrhea virus (BVDV) infection is associated with decreased vitamin D and E status of vitamin-replete preruminant calves. Journal of Dairy Science 97, 5566-5579. https://doi.org/10.3168/jds.2014-8293
  • Norman, A. W., Bouillon, R., Farach-Carson, M. C., et al. (1993) Demonstration that 1 beta,25-dihydroxyvitamin D3 is an antagonist of the nongenomic but not genomic biological responses and biological profile of the three A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D3. The Journal of Biological Chemistry 268, 20022-20030
  • O'Brien, M. A., McMichael, M. A. & Le Boedec, K. (2018) 25-Hydroxyvitamin D concentrations in dogs with naturally acquired blastomycosis. Journal of Veterinary Internal Medicine 32, 1684-1691. https://doi.org/10.1111/jvim.15255
  • Osuga, T., Nakamura, K., Morita, T., et al. (2015) Vitamin D status in different stages of disease severity in dogs with chronic valvular heart disease. Journal of Veterinary Internal Medicine 29, 1518-1523. https://doi.org/10.1111/jvim.13606
  • Parker, V. J., Harjes, L. M., Dembek, K., et al. (2017a) Association of vitamin D metabolites with parathyroid hormone, fibroblast growth factor-23, calcium, and phosphorus in dogs with various stages of chronic kidney disease. Journal of Veterinary Internal Medicine 31, 791-798. https://doi.org/10.1111/jvim.14653
  • Parker, V. J., Rudinsky, A. J. & Chew, D. J. (2017b) Vitamin D metabolism in canine and feline medicine. Journal of the American Veterinary Medical Association 250, 1259-1269. https://doi.org/10.2460/javma.250.11.1259
  • Parker, V. J., Rudinsky, A. J., Benedict, J. A., et al. (2020) Effects of calcifediol supplementation on markers of chronic kidney disease-mineral and bone disorder in dogs with chronic kidney disease. Journal of Veterinary Internal Medicine 34, 2497-2506. https://doi.org/10.1111/jvim.15949
  • Perry, B. H., McMichael, M., Rick, M., et al. (2016) Reduction of serum 25-hydroxyvitamin D concentrations with intravenous lipid emulsion in a dog. The Canadian Veterinary Journal 57, 1284-1286
  • Polzin, D., Ross, S., Osborne, C., et al. (2005) Clinical benefit of calcitriol in canine chronic kidney disease. Journal of Veterinary Internal Medicine 19, 433
  • Prosser, D. E. & Jones, G. (2004) Enzymes involved in the activation and inactivation of vitamin D. Trends in Biochemical Sciences 29, 664-673. https://doi.org/10.1016/j.tibs.2004.10.005
  • Provvedini, D. M., Tsoukas, C. D., Deftos, L. J., et al. (1983) 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 221, 1181-1183
  • Rassnick, K. M., Muindi, J. R., Johnson, C. S., et al. (2008) In vitro and in vivo evaluation of combined calcitriol and cisplatin in dogs with spontaneously occurring tumors. Cancer Chemotherapy and Pharmacology 62, 881-891. https://doi.org/10.1007/s00280-008-0678-x
  • Reddy, G. S. & Tserng, K. Y. (1989) Calcitroic acid, end product of renal metabolism of 1,25-dihydroxyvitamin D3 through C-24 oxidation pathway. Biochemistry 28, 1763-1769. https://doi.org/10.1021/bi00430a051
  • Reddy, S. V., Ramesh, V. & Bhatia, E. (2013) Double blind randomized control study of intramuscular vitamin D3 supplementation in tropical calcific pancreatitis. Calcified Tissue International 93, 48-54. https://doi.org/10.1007/s00223-013-9726-6
  • Reid, D., Toole, B. J., Knox, S., et al. (2011) The relation between acute changes in the systemic inflammatory response and plasma 25-hydroxyvitamin D concentrations after elective knee arthroplasty. The American Journal of Clinical Nutrition 93, 1006-1011. https://doi.org/10.3945/ajcn.110.008490
  • Rhead, B., Baarnhielm, M., Gianfrancesco, M., et al. (2016) Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk. Neurology. Genetics 2, e97. https://doi.org/10.1212/NXG.0000000000000097
  • Rhieu, S. Y., Annalora, A. J., Wang, G., et al. (2013) Metabolic stability of 3-epi-1alpha,25-dihydroxyvitamin D3 over 1 alpha 25-dihydroxyvitamin D3: metabolism and molecular docking studies using rat CYP24A1. Journal of Cellular Biochemistry 114, 2293-2305. https://doi.org/10.1002/jcb.24576
  • Rodriguez-Cortes, A., Martori, C., Martinez-Florez, A., et al. (2017) Canine Leishmaniasis progression is associated with vitamin D deficiency. Scientific Reports 7, 3346. https://doi.org/10.1038/s41598-017-03662-4
  • Rosa, C. T., Schoeman, J. P., Berry, J. L., et al. (2013) Hypovitaminosis d in dogs with spirocercosis. Journal of Veterinary Internal Medicine 27, 1159-1164. https://doi.org/10.1111/jvim.12161
  • Rumbeiha, W. K., Kruger, J. M., Fitzgerald, S. F., et al. (1999) Use of pamidronate to reverse vitamin D3-induced toxicosis in dogs. American Journal of Veterinary Research 60, 1092-1097
  • Saedi, N., Horn, R., Muffoletto, B., et al. (2007) Death of a dog caused by calcipotriene toxicity. Journal of the American Academy of Dermatology 56, 712-713. https://doi.org/10.1016/j.jaad.2006.12.033
  • Savary, K. C., Price, G. S. & Vaden, S. L. (2000) Hypercalcemia in cats: a retrospective study of 71 cases (1991-1997). Journal of Veterinary Internal Medicine 14, 184-189
  • Schenk, A., Lux, C., Lane, J., et al. (2018) Evaluation of zoledronate as treatment for hypercalcemia in four dogs. Journal of the American Animal Hospital Association 54, e54604. https://doi.org/10.5326/JAAHA-MS-6681
  • Schreiner, C. A. & Nagode, L. A. (2003) Vitamin D-dependent rickets type 2 in a four-month-old cat. Journal of the American Veterinary Medical Association 222, 337-339, 315-336. https://doi.org/10.2460/javma.2003.222.337
  • Schulze, C., Rothuizen, J., van Sluijs, F. J., et al. (2000) Extrahepatic biliary atresia in a border collie. The Journal of Small Animal Practice 41, 27-30
  • Schwartz, J. B., Gallagher, J. C., Jorde, R., et al. (2018) Determination of free 25(OH)D concentrations and their relationships to total 25(OH)D in multiple clinical populations. The Journal of Clinical Endocrinology and Metabolism 103, 3278-3288. https://doi.org/10.1210/jc.2018-00295
  • Scragg, R., Stewart, A. W., Waayer, D., et al. (2017) Effect of monthly high-dose vitamin D supplementation on cardiovascular disease in the vitamin D assessment study: a randomized clinical trial. JAMA Cardiology 2, 608-616. https://doi.org/10.1001/jamacardio.2017.0175
  • Scragg, R., Khaw, K. T., Toop, L., et al. (2018) Monthly high-dose vitamin D supplementation and cancer risk: a post hoc analysis of the vitamin D assessment randomized clinical trial. JAMA Oncology 4, e182178. https://doi.org/10.1001/jamaoncol.2018.2178
  • Selting, K. A., Sharp, C. R., Ringold, R., et al. (2016) Serum 25-hydroxyvitamin D concentrations in dogs - correlation with health and cancer risk. Veterinary and Comparative Oncology 14, 295-305. https://doi.org/10.1111/vco.12101
  • Sharp, C. R., Selting, K. A. & Ringold, R. (2015) The effect of diet on serum 25-hydroxyvitamin D concentrations in dogs. BMC Research Notes 8, 442. https://doi.org/10.1186/s13104-015-1360-0
  • Shimada, T., Kakitani, M., Yamazaki, Y., et al. (2004) Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. The Journal of Clinical Investigation 113, 561-568. https://doi.org/10.1172/JCI19081
  • Siu-Caldera, M. L., Sekimoto, H., Weiskopf, A., et al. (1999) Production of 1alpha,25-dihydroxy-3-epi-vitamin D3 in two rat osteosarcoma cell lines (UMR 106 and ROS 17/2.8): existence of the C-3 epimerization pathway in ROS 17/2.8 cells in which the C-24 oxidation pathway is not expressed. Bone 24, 457-463. https://doi.org/10.1016/s8756-3282(99)00019-8
  • Spoo, J. W., Downey, R. L., Griffitts, C., et al. (2015) Plasma vitamin D metabolites and C-reactive protein in stage-stop racing endurance sled dogs. Journal of Veterinary Internal Medicine 29, 519-525. https://doi.org/10.1111/jvim.12546
  • Sprinkle, M. C., Hooper, S. E. & Backus, R. C. (2018) Previously undescribed vitamin D C-3 epimer occurs in substantial amounts in the blood of cats. Journal of Feline Medicine and Surgery 20, 83-90. https://doi.org/10.1177/1098612X17693523
  • St-Arnaud, R. (2010) CYP24A1-deficient mice as a tool to uncover a biological activity for vitamin D metabolites hydroxylated at position 24. The Journal of Steroid Biochemistry and Molecular Biology 121, 254-256. https://doi.org/10.1016/j.jsbmb.2010.02.002
  • Stepman, H. C., Vanderroost, A., Van Uytfanghe, K., et al. (2011) Candidate reference measurement procedures for serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 by using isotope-dilution liquid chromatography-tandem mass spectrometry. Clinical Chemistry 57, 441-448. https://doi.org/10.1373/clinchem.2010.152553
  • Stern, J. A., Chew, D. J., Schissler, J. R., et al. (2011) Cutaneous and systemic blastomycosis, hypercalcemia, and excess synthesis of calcitriol in a domestic shorthair cat. Journal of the American Animal Hospital Association 47, e116-e120. https://doi.org/10.5326/JAAHA-MS-5566
  • Su, Z., Narla, S. N. & Zhu, Y. (2014) 25-Hydroxyvitamin D: analysis and clinical application. Clinica Chimica Acta 433, 200-205. https://doi.org/10.1016/j.cca.2014.03.022
  • Tai, S. S. & Nelson, M. A. (2015) Candidate reference measurement procedure for the determination of (24R),25-dihydroxyvitamin D3 in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry. Analytical Chemistry 87, 7964-7970. https://doi.org/10.1021/acs.analchem.5b01861
  • Tai, S. S., Bedner, M. & Phinney, K. W. (2010) Development of a candidate reference measurement procedure for the determination of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum using isotope-dilution liquid chromatography-tandem mass spectrometry. Analytical Chemistry 82, 1942-1948. https://doi.org/10.1021/ac9026862
  • Tai, S. S., Nelson, M. A., Bedner, M., et al. (2017) Development of standard reference material (SRM) 2973 vitamin D metabolites in frozen human serum (high level). Journal of AOAC International 100, 1294-1303. https://doi.org/10.5740/jaoacint.17-0182
  • Tal, M., Parr, J. M., MacKenzie, S., et al. (2018) Dietary imbalances in a large breed puppy, leading to compression fractures, vitamin D deficiency, and suspected nutritional secondary hyperparathyroidism. The Canadian Veterinary Journal 59, 36-42
  • Tanner, E. & Langley-Hobbs, S. J. (2005) Vitamin D-dependent rickets type 2 with characteristic radiographic changes in a 4-month-old kitten. Journal of Feline Medicine and Surgery 7, 307-311. https://doi.org/10.1016/j.jfms.2005.01.003
  • Teshima, T., Kurita, S., Sasaki, T., et al. (2019) A genetic variant of CYP2R1 identified in a cat with type 1B vitamin D-dependent rickets: a case report. BMC Veterinary Research 15, 62. https://doi.org/10.1186/s12917-019-1784-1
  • Titmarsh, H., Gow, A. G., Kilpatrick, S., et al. (2015a) Association of vitamin D status and clinical outcome in dogs with a chronic enteropathy. Journal of Veterinary Internal Medicine 29, 1473-1478. https://doi.org/10.1111/jvim.13603
  • Titmarsh, H., Kilpatrick, S., Sinclair, J., et al. (2015b) Vitamin D status predicts 30 day mortality in hospitalised cats. PLoS One 10, e0125997. https://doi.org/10.1371/journal.pone.0125997
  • Titmarsh, H. F., Gow, A. G., Kilpatrick, S., et al. (2015c) Low vitamin D status is associated with systemic and gastrointestinal inflammation in dogs with a chronic enteropathy. PLoS One 10, e0137377. https://doi.org/10.1371/journal.pone.0137377
  • Titmarsh, H. F., Lalor, S. M., Tasker, S., et al. (2015d) Vitamin D status in cats with feline immunodeficiency virus. Veterinary Medicine and Science 1, 72-78. https://doi.org/10.1002/vms3.11
  • Titmarsh, H. F., Cartwright, J. A., Kilpatrick, S., et al. (2016) Relationship between vitamin D status and leukocytes in hospitalised cats. Journal of Feline Medicine and Surgery 19, 364-369. https://doi.org/10.1177/1098612X15625454
  • Titmarsh, H. F., Woods, G. A., Cartwright, J. A., et al. (2020) Low vitamin D status is associated with anaemia in hospitalised cats. The Veterinary Record 187, e6. https://doi.org/10.1136/vr.105626
  • Tornqvist-Johnsen, C., Schnabel, T., Gow, A. G., et al. (2020) Investigation of the relationship between ionised and total calcium in dogs with ionised hypercalcaemia. The Journal of Small Animal Practice 61, 247-252. https://doi.org/10.1111/jsap.13109
  • Tuckey, R. C., Tang, E. K. Y., Maresse, S. R., et al. (2019) Catalytic properties of 25-hydroxyvitamin D3 3-epimerase in rat and human liver microsomes. Archives of Biochemistry and Biophysics 666, 16-21. https://doi.org/10.1016/j.abb.2019.03.010
  • Volmer, D. A., Mendes, L. R. & Stokes, C. S. (2015) Analysis of vitamin D metabolic markers by mass spectrometry: current techniques, limitations of the "gold standard" method, and anticipated future directions. Mass Spectrometry Reviews 34, 2-23. https://doi.org/10.1002/mas.21408
  • Wakshlag, J. J., Rassnick, K. M., Malone, E. K., et al. (2011) Cross-sectional study to investigate the association between vitamin D status and cutaneous mast cell tumours in Labrador retrievers. The British Journal of Nutrition 106(Suppl 1), S60-S63. https://doi.org/10.1017/S000711451100211X
  • Waldron, J. L., Ashby, H. L., Cornes, M. P., et al. (2013) Vitamin D: a negative acute phase reactant. Journal of Clinical Pathology 66, 620-622. https://doi.org/10.1136/jclinpath-2012-201301
  • Ware, W. A., Freeman, L. M., Rush, J. E., et al. (2020) Vitamin D status in cats with cardiomyopathy. Journal of Veterinary Internal Medicine 34, 1389-1398. https://doi.org/10.1111/jvim.15833
  • Wehner, A., Katzenberger, J., Groth, A., et al. (2013) Vitamin D intoxication caused by ingestion of commercial cat food in three kittens. Journal of Feline Medicine and Surgery 15, 730-736. https://doi.org/10.1177/1098612X12472180
  • Weidner, N., Woods, J. P., Conlon, P., et al. (2017) Influence of various factors on circulating 25(OH) vitamin D concentrations in dogs with cancer and healthy dogs. Journal of Veterinary Internal Medicine 31, 1796-1803. https://doi.org/10.1111/jvim.14834
  • Welsh, J. (2012) Cellular and molecular effects of vitamin D on carcinogenesis. Archives of Biochemistry and Biophysics 523, 107-114. https://doi.org/10.1016/j.abb.2011.10.019
  • Wennogle, S. A., Priestnall, S. L., Suarez-Bonnet, A., et al. (2019) Comparison of clinical, clinicopathologic, and histologic variables in dogs with chronic inflammatory enteropathy and low or normal serum 25-hydroxycholecalciferol concentrations. Journal of Veterinary Internal Medicine 33, 1995-2004. https://doi.org/10.1111/jvim.15614
  • Whitehead, J., Quimby, J. & Bayliss, D. (2015) Seizures associated with hypocalcemia in a Yorkshire terrier with protein-losing enteropathy. Journal of the American Animal Hospital Association 51, 380-384. https://doi.org/10.5326/JAAHA-MS-6205
  • Willcox, J. L., Hammett-Stabler, C. & Hauck, M. L. (2016) Serum 25-hydroxyvitamin D concentrations in dogs with osteosarcoma do not differ from those of age- and weight-matched control dogs. Veterinary Journal 217, 132-133. https://doi.org/10.1016/j.tvjl.2016.10.005
  • Woods, G. A., Willems, A., Hurst, E., et al. (2019) Epileptic seizure in a cocker spaniel associated with hypocalcaemia, hypovitaminosis D and a protein-losing enteropathy. Veterinary Record Case Report 7, e000813
  • Young, L. R. & Backus, R. C. (2016) Oral vitamin D supplementation at five times the recommended allowance marginally affects serum 25-hydroxyvitamin D concentrations in dogs. Journal of Nutritional Science 5, e31. https://doi.org/10.1017/jns.2016.23
  • Zehnder, D., Bland, R., Walker, E. A., et al. (1999) Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney. Journal of the American Society of Nephrology 10, 2465-2473
  • Zehnder, D., Bland, R., Williams, M. C., et al. (2001) Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. The Journal of Clinical Endocrinology and Metabolism 86, 888-894. https://doi.org/10.1210/jcem.86.2.7220
  • Zhu, J. G., Ochalek, J. T., Kaufmann, M., et al. (2013) CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo. Proceedings of the National Academy of Sciences of the United States of America 110, 15650-15655. https://doi.org/10.1073/pnas.1315006110

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