Cancer in children (Leukemia) more likely to recur if 20-30 ng of vitamin D – Nov 2022


Vitamin D abnormalities of children with recurrence of malignancy and comparison with newly diagnosed patients

Caspian J Intern Med . 2022 Fall;13(4):735-740. doi: 10.22088/cjim.13.4.735.
Nahid Reisi 1 , Azar Mirzaei 2 , Alireza Moafi 1 , Pouran Raeissi 3 , Maryam Naghdhassani 4

A = Leukemia recur, B = new Leukemia, C = Healthy
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Background: Vitamin D (Vit-D) is a necessary ingredient for human growth and its deficiency may increase the risk of cancer and its recurrence. The main purpose of this research was to assess the levels of Vit-D in children with recurrence of malignancy and compare it with new cases of malignancy and the control group.

Methods: The status of 25(OH) Vit-D was determined utilizing the HPLC method in 47 patients with recurrence of malignancy (group A), 50 children with new malignancy (group B ) and 49 normal healthy siblings of the two groups as a control (group C).

Results: Vit-D was low (<30 ng/ml) in the 92% of patients with recurrence of malignancy, which was a significant difference compared to groups B (60%) and C (45%). Vit-D insufficiency (10-30 ng/dl) in group A was also higher than the other two groups. The mean levels of Vit-D in patients with recurrence were significantly lower than the new cases and controls. Low Vit-D (<30 ng/ml) in group A in both male and female, and also in all ages (<6 and ≥ 6 years) was higher than groups B and C. Also, low Vit-D in terms of the type of malignancy in group A was higher than group B only in leukemic patients while this was not different for non-leukemic patients in these two groups.

Conclusion: Results of this study showed an increased prevalence of low Vit-D in children with recurrence of malignancies. Therefore, it may increase the risk of recurrence of malignancies in children.

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VitaminDWiki Infant-Child pages with CANCER in the title

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Items found: 16
Title Modified
Childhood Cancers - Vitamin D can help - many studies 20 Jan, 2024
Childhood Cancer Survivors have worse arteries due to anticancer therapy – May 2023 30 May, 2023
Cancer in children (Leukemia) more likely to recur if 20-30 ng of vitamin D – Nov 2022 25 Nov, 2022
Cancer during childhood - many studies 25 Nov, 2022
Poor prognosis of solid childhood cancers 14.7 X more likely with a poor Vitamin D Receptor – July 2022 27 Jul, 2022
Newly diagnosed Children with Cancer have low vitamin D, especially if black - May 2022 16 Jun, 2022
Cancer of the eye in children: most of the risk factors are associated with low vitamin D – July 2021 26 Dec, 2021
Childhood cancers – give Vitamin D loading dose if low – Oct 2021 27 Oct, 2021
Children's Cancer hospital now testing vitamin D frequently and supplementing weekly – July 2021 22 Jul, 2021
Consensus recommends at least 20 ng of Vitamin D for childhood cancer (not nearly enough) – June 2021 08 Jun, 2021
Relapses of Acute Lymphoblastic Leukemia (ALL) – 1 in 5 are due to genes mutated by chemotherapy – Nov 2019 10 Nov, 2019
Childhood Cancer survivors – only 1 in 25 had consumed Vitamin D RDA – Oct 2019 22 Oct, 2019
Children with cancer were deficient in Vitamin D, Vitamin C, and Zinc – July 2019 10 Jul, 2019
Childhood cancer survivors have increased chronic health problems as adults – Sept 2017 13 Oct, 2017
Children with Cancer were 3X more likely to be vitamin D deficient – July 2013 05 Jan, 2014
Vitamin D levels very low for some childhood cancers, then got lower – Sept 2012 29 Sep, 2012

Some health problems recur if low vitamin D


A health problem associated with low D is often associated with other low D problems (if not supplement)

Diseases that may be related via low vitamin D here is a portion of a long list
88+ Disease associations:   Disease 1 ==> Disease 2 (both associated with low vitamin D


Note: Some health problems protect themselves by deactivating the Vitamin D Receptor

Cancer removal does not reactivate the Vitamin D Receptor
A deactivated VDR results in less Vitamin D getting to cells
Which results in more health problems in the future, even if vitamin D levels are raised to 30 ng by supplementation


See also in VitaminDWiki

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