Atrial Fibrillation strongly associated with some vitamin D binding protein – Dec 2017

Genetically deprived vitamin D exposure predisposes to atrial fibrillation.

Europace. 2017 Dec 1;19(suppl_4):iv25-iv31. doi: 10.1093/europace/eux312.
Chan YH1, Yiu KH1,2, Hai JJ1, Chan PH1, Lam TH3, Cowling BJ3, Sham PC4, Lau CP1, Lam KS2,5, Siu CW1,2, Tse HF1,2.
1 Division of Cardiology, Queen Mary Hospital, The U. of Hong Kong, Hong Kong SAR, China.
2 Research Center of Heart, Brain, Hormone and Healthy Ageing, The U. of Hong Kong, Hong Kong SAR, China.
3 School of Public Health, The U. of Hong Kong, Hong Kong SAR, China.
4 Department of Psychiatry and Centre for Genomic Sciences, The U. of Hong Kong, Hong Kong SAR, China.
5 Division of Endocrinology, Queen Mary Hospital, The U. of Hong Kong, Hong Kong SAR, China.

VitaminDWiki

VitaminDWiki pages with ATRIAL OR AFIB OR ARRHY in title (15 as of Sept 2022)

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Items found: 16

Title		Modified
Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies		11 Jul, 2023
Atrial Fibrillation - now 1 in 45 in the UK - May 2023		26 May, 2023
Atrial Fibrillation risk reduced by 0.84 in those raising Vitamin D levels above 30 ng – RCT April 2022		04 Apr, 2022
Atrial fibrillation - Vitamin D improved 1 of 4 measures – March 2015		27 Jun, 2018
Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018		27 Jun, 2018
Atrial Fibrillation strongly associated with some vitamin D binding protein – Dec 2017		09 Dec, 2017
Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016		15 Oct, 2017
Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015		10 Dec, 2016
Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016		26 Sep, 2016
Atrial fibrillation and low vitamin D: both types of AF are very low – Jan 2014		01 Nov, 2015
Atrial Fibrillation - remineralize your heart - Aug 2015		25 Oct, 2015
Calcium supplementation associated with 3.9X increase risk of atrial fibrillation – June 2015		02 Sep, 2015
Atrial fibrillation reduced with modest vitamin D levels (did not consider Magnesium) – May 2015		05 May, 2015
Higher vitamin D levels associated with health and lower risk of atrial fibrillation – May 2015		02 May, 2015
Active vitamin D decreased atrial fibrillation occurrence by 9X and duration by 77X (rabbits) – March 2014		13 Feb, 2015
Atrial Fibrillation associated with lower levels of vitamin D – July 2012		13 Dec, 2013

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AIMS:
Low vitamin D level is associated with atrial fibrillation (AF) and may be implicated in its pathogenesis.

METHODS AND RESULTS:
We studied single nucleotide polymorphisms (SNPs) of vitamin D mechanistic pathways and serum 25-hydroxyvitamin D [25(OH)D] levels in an age- and gender-matched case-control study (controls without AF: mean age 68.6 ± 8.7 years, female 25%; n = 1019; with AF: mean age 69.7 ± 9.5 years, female 30%; n = 156) recruited from a Chinese clinical cohort of patients with stable coronary artery disease. Twelve SNPs involved in the vitamin D mechanistic pathways were studied [

biosynthetic: rs4646536, rs10877012, rs3829251, rs1790349;
activation: rs2060793, rs1993116;
vitamin D-binding protein (VBP)/group-specific component (GC): rs4588, rs7041, rs2282679, rs1155563; and
vitamin D receptor: rs1544410, rs10735810].

A genetic risk score (GRS) (0-8) was constructed from SNPs associated with serum 25(OH)D as a proxy to lifelong vitamin D-deficient state.
All 4 SNPs involved in the VBP/GC were significantly associated with serum 25(OH)D (rs4588, P < 0.001; rs2282679, P < 0.001; rs7041, P = 0.011; rs1155563, P < 0.001; all other SNPs, P > 0.05). Vitamin D GRS (points 0-8) generated from these 4 SNPs was independently predictive of serum 25(OH)D [B = 0.54, 95% confidence interval (CI) 0.30-0.79; P < 0.001]. Genetically deprived vitamin D status as denoted by a low GRS (0-3) independently predicted an increased risk of AF, compared to a high GRS (4-8) (odds ratio = 1.848, 95% CI 1.217-2.805; P = 0.004).

CONCLUSION:
Genetically deprived vitamin D exposure predisposes to increased AF among patients with coronary artery disease. Whether VBP/GC may alter the risk of AF via alternative mechanisms warrants further studies.

KEYWORDS:
25-Hydroxyvitamin D; Atrial fibrillation; Genetic polymorphism; Vitamin D-binding protein

PMID: 29220424 DOI: 10.1093/europace/eux312