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Atrial fibrillation and low vitamin D: both types of AF are very low – Jan 2014

The Effects of Vitamin D Deficiency on Atrial Fibrillation - Jan 2014

CLIN APPL THROMB HEMOST January 2014 vol. 20 no. 1 98-103
Mehmet Demir, MD1⇑
Umut Uyan, MD1
Mehmet Melek, MD1
1Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey
Mehmet Demir, Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Yaseminpark sit 4E D11 Osmangazi, 16100 Bursa, Turkey. Email: drmehmetmd@gmail

Background: Vitamin D deficiency is associated with cardiovascular disease such as coronary artery disease, heart failure, and hypertension. Vitamin D deficiency activates the renin–angiotensin–aldosterone system, which affects the cardiovascular system. For this reason, it could be suggested that there is a relationship between vitamin D deficiency and atrial fibrillation (AF). In our study, we compared 25-hydroxyvitamin D (25-OHD) levels between nonvalvular AF, valvular AF, and control groups in sinus rhythm.

Method: A total of 102 patients with nonvalvular chronic AF without any other cardiovascular disease (mean age 62.51 ± 5.88; group I) and 96 patients with AF, which is associated with mitral valve disease (mean age 61.51 ± 5; group II) were included in our study. Of all, 100 age-matched healthy people with sinus rhythm were accepted as control groups (mean age 61.35 ± 5.44). Routine biochemical parameters, 25-OHD and parathormone levels were performed.

Results: Baseline characteristics of the study groups were comparable. Group I patients had a lower vitamin D level than group II and the control group (6.51 ± 4.89, 9.24 ± 7.39, and 11.18 ± 6.98 ng/mL, P < .001, respectively). In groups I and II, the patients’ left atrium diameter and systolic pulmonary artery pressure are higher than the control group.

Conclusion: As a result, our study revealed a relationship between vitamin D deficiency and nonvalvular AF.

Summary by VitaminDWiki
6.5 ng nonvalvular chronic AF
9.2 ng mitral valve disease AF
11.2 ng controls (Recall that vitamin D levels are very low in the Middle East)

Atrial fibrillation associated with low vitamin D in 3 of 6 studies - April 2015

Vitamin D deficiency and atrial fibrillation
International Journal of Cardiology, Volume 184, 1 April 2015, Pages 159–162, doi:10.1016/j.ijcard.2015.02.012
Joseph Thompsona, Rynda Nitiahpapanda, Prashan Bhattia, Antonios Kourliourosb, ,
• Vitamin D mediates oxidative stress, calcium homeostasis and the RAAS.
• Experimental studies suggest a role for vitamin D deficiency in atrial fibrillation.
• There is strong evidence for an association between winter season and AF.
• Observational studies investigating vitamin D status and AF provide equivocal results.

Vitamin D deficiency has been linked with hypertension, coronary artery disease, and stroke, but there is no consensus regarding the possible association between vitamin D deficiency and atrial fibrillation (AF). Vitamin D

  • negatively regulates the renin–angiotensin–aldosterone-system (RAAS),
  • mediates calcium homeostasis,
  • binds to vitamin D receptors on cardiac myocytes, and
  • has antioxidant properties that may reduce levels of reactive oxygen species (ROS) in the atria,
    which contribute to inflammation and proarrhythmic substrate formation.

As vitamin D status is a readily modifiable risk factor this association has potential clinical implications.

An extensive search of the literature identified six studies that specifically investigated vitamin D status and AF.

Results were equivocal with three studies identifying a positive association between vitamin D deficiency and AF, whilst two studies suggested there may be no association. Additionally, one study indicated that elevated vitamin D levels are associated with AF. Whilst the weight of the evidence suggests that there may be an association between vitamin D deficiency and AF, incomparable study designs and methodological limitations hinder interpretation of the current body of evidence. Further work taking into account considerations raised within this paper is required to better understand the relationship between vitamin D status and AF.

VitaminDWiki pages containing ATRIAL FIBRILLATION OR AFIB in title (17 as of July 2021)

Items found: 20
Title Modified
Half as much AFIB after bypass if 600,000 IU of vitamin D before surgery – RCT April 2022 13 Nov, 2022
Atrial Fibrillation in VitaminDWiki - many studies 07 Sep, 2022
Atrial Fibrillation risk reduced by 0.84 in those raising Vitamin D levels above 30 ng – RCT April 2022 04 Apr, 2022
Getting Vitamin D before heart surgery prevented Afib in those who had been deficient – July 2018 16 Jan, 2019
Heart problems such as Afib related to little Magnesium, Omega-3, Vitamin D getting to tissues 14 Dec, 2018
Osteoporosis treatment with Vitamin D – far healthier and 10X fewer afib events (vs bisphosphonates) – Oct 2018 30 Oct, 2018
Afib increase by 3X for the 1 in 16 people having poor genes (example of health problem) – Aug 2018 14 Oct, 2018
Atrial fibrillation - Vitamin D improved 1 of 4 measures – March 2015 27 Jun, 2018
Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018 27 Jun, 2018
Atrial Fibrillation strongly associated with some vitamin D binding protein – Dec 2017 09 Dec, 2017
Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016 15 Oct, 2017
Atrial fibrillation sometimes treated by Omega-3 – meta-analysis Sept 2015 10 Dec, 2016
Atrial Fibrillation 1.3 times more likely if low vitamin D – meta-analysis Sept 2016 26 Sep, 2016
Atrial fibrillation and low vitamin D: both types of AF are very low – Jan 2014 01 Nov, 2015
Atrial Fibrillation - remineralize your heart - Aug 2015 25 Oct, 2015
Calcium supplementation associated with 3.9X increase risk of atrial fibrillation – June 2015 02 Sep, 2015
Atrial fibrillation reduced with modest vitamin D levels (did not consider Magnesium) – May 2015 05 May, 2015
Higher vitamin D levels associated with health and lower risk of atrial fibrillation – May 2015 02 May, 2015
Active vitamin D decreased atrial fibrillation occurrence by 9X and duration by 77X (rabbits) – March 2014 13 Feb, 2015
Atrial Fibrillation associated with lower levels of vitamin D – July 2012 13 Dec, 2013