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Obese need 2X to 3X more vitamin D - Nov 2014

Obese need 2.5 times as much vitamin D as normals


  • Normal weight     Obese     (50 ng = 125 nanomole)

Response vs obesity @ /is.gd/2Xobese

The Importance of Body Weight for the Dose Response Relationship of Oral Vitamin D Supplementation and Serum 25-Hydroxyvitamin D in Healthy Volunteers

PLOS ONE, Published: November 05, 2014DOI: 10.1371/journal.pone.0111265
John Paul Ekwaru, Jennifer D. Zwicker, Michael F. Holick, Edward Giovannucci, Paul J. Veugelers

Unlike vitamin D recommendations by the Institute of Medicine, the Clinical Practice Guidelines by the Endocrine Society acknowledge body weight differentials and recommend obese subjects be given two to three times more vitamin D to satisfy their body's vitamin D requirement. However, the Endocrine Society also acknowledges that there are no good studies that clearly justify this. In this study we examined the combined effect of vitamin D supplementation and body weight on serum 25-hydroxyvitamin (25(OH)D) and serum calcium in healthy volunteers.

We analyzed 22,214 recordings of vitamin D supplement use and serum 25(OH)D from 17,614 healthy adult volunteers participating in a preventive health program. This program encourages the use of vitamin D supplementation and monitors its use and serum 25(OH)D and serum calcium levels. Participants reported vitamin D supplementation ranging from 0 to 55,000 IU per day and had serum 25(OH)D levels ranging from 10.1 to 394 nmol/L. The dose response relationship between vitamin D supplementation and serum 25(OH)D followed an exponential curve.

On average, serum 25(OH)D increased by 12.0 nmol/L per 1,000 IU in the supplementation interval of 0 to 1,000 IU per day and by 1.1 nmol/L per 1,000 IU in the supplementation interval of 15,000 to 20,000 IU per day.
BMI, relative to absolute body weight, was found to be the better determinant of 25(OH)D.
Relative to normal weight subjects, obese and overweight participants had serum 25(OH)D that were on average 19.8 nmol/L and 8.0 nmol/L lower, respectively (P<0.001).
We did not observe any increase in the risk for hypercalcemia with increasing vitamin D supplementation.
We recommend vitamin D supplementation be 2 to 3 times higher for obese subjects and 1.5 times higher for overweight subjects relative to normal weight subjects.
This observational study provides body weight specific recommendations to achieve 25(OH)D targets.

 Download the PDF from VitaminDWiki

'Even more vitamin D needed if:

  1. Dark Skin color - will take longer to reach equilibrium
  2. Excess toxins such as DDT, PCB, Alcohol
  3. Health problems which consume Vitamin D
  4. Health problems which reduce the response of Vitamin D consumed
    Especially problems of the Liver (even fatty liver) and Kidney
  5. Lacking Cofactors such as Magnesium and Omega-3
  6. Have a high amount of Vitamin A in diet (too much vitamin A blocks vitamin D)
  7. You are smoking – known to reduce dose/response by 20%
  8. Recent surgery/trauma – which consumes a lot of vitamin D
  9. Drugs being taken which reduce vitamin D levels - statins, chemotherapy, etc.
  10. Senior - Vitamin D is not as bio-available
  11. Pregnancy
  12. Using oil form of vitamin D (needs about 20% more)

See also VitaminDWiki

Obese need more Vitamin D

  • Normal weight     Obese     (50 ng = 125 nanomole)

Click here for 2014 study

Obese need more Vitamin D: Volume dilution, IU per pound, or BMI – RCT Dec 2012 has the following chart

BMI formula and chart


English BMI Formula
BMI = ( Weight in Pounds / ( Height in inches x Height in inches ) ) x 703
Metric BMI Formula
BMI = ( Weight in Kilograms / ( Height in Meters x Height in Meters ) )

298 citations of the study as of Dec 2023

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short url = https://is.gd/vdwobese

Obese need 2X to 3X more vitamin D - Nov 2014        
21122 visitors, last modified 24 Dec, 2023,
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Attached files

ID Name Comment Uploaded Size Downloads
7043 BMI chart.jpg admin 06 Sep, 2016 76.28 Kb 15681
6886 Obese 2.5.jpg admin 19 Jul, 2016 32.81 Kb 47862
4546 Response vs obesity.pdf admin 06 Nov, 2014 534.73 Kb 1491