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14000 IU vitamin D (50000 twice a week) often stops Sickle Cell pain

Several items on this page

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Can sometimes stop sickle cell pain with vitamin D - Oct 2011

Complete Resolution of Sickle Cell Chronic Pain With High Dose Vitamin D Therapy:
A Case Report and Review of the Literature

Journal of Pediatric Hematology/Oncology: October 2011 - Volume 33 - Issue 7 - p 549–551, doi: 10.1097/MPH.0b013e31821ed3ea
Osunkwo, Ifeyinwa MD, MPH ify.osunkwo at choa.org
Aflac Center for Cancer and Blood Disorders Service Comprehensive Sickle Cell Program of Children's Healthcare of Atlanta, Atlanta, GA, USA.

With age, individuals with sickle cell disease (SCD) experience daily chronic pain.
Vitamin D deficiency (VDD) can result in chronic pain, osteoporosis, fractures, and muscle weakness.
Several studies report a high prevalence of VDD in SCD; however, the clinical correlates have not been well described.
We describe a case of SCD chronic pain associated with profound VDD, osteoporosis, and osteonecrosis.
Treatment with high-dose vitamin D resulted in complete resolution of chronic pain symptoms and improvement in bone density.
Randomized studies of vitamin D in SCD may help elucidate its role in the management of chronic pain and bone disease.

PMID: 21941148
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From the Author: 600,000 units over 6 weeks.

This particular patient needed 2 courses, so received a total of 1.2 million units over 3 months.
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Sickle cell pain reduced with daily average of 14000 IU vitamin D – pilot RCT Sept 2012 same author

High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease:
results of a randomized double blind pilot study

British Journal of Haematology
Ifeyinwa Osunkwo 1,2, ify.osunkwo at choa.org, Thomas R. Ziegler 3, Jessica Alvarez 3, Courtney McCracken 2, Korin Cherry 1, Chinyere E. Osunkwo 1, Solomon F. Ofori-Acquah 1,2, Samit Ghosh 2, Adeolu Ogunbobode 2, Jim Rhodes 1, James R. Eckman 4,5, Carlton Dampier 1,2, Vin Tangpricha 3
1 Aflac Cancer and Blood Disorders Center of Children's Healthcare of Atlanta, Atlanta, GA, USA
2 Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
3 Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA, USA
4 Department of Hematology Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
5 Georgia Comprehensive Sickle Cell Center of Grady Memorial Hospital, Atlanta, GA, USA
Article first published online: 28 AUG 2012, DOI: 10.1111/bjh.12019

We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD).
Subjects were given a 6-week course of oral high-dose cholecalciferol (40 000–100 000 IU per week) or placebo and monitored prospectively for a period of six months.
Vitamin D insufficiency and deficiency was present at baseline in 82·5% and 52·5% of subjects, respectively.

Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher physical activity quality-of-life scores.

These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD.
Larger prospective studies with longer duration are needed to confirm these effects.

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