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Omega-3 reduces Lupus, Rheumatoid Arthritis and Osteoarthritis – review Sept 2017

Omega-3 Fatty Acids in Rheumatic Diseases: A Critical Review.

JCR: Journal of Clinical Rheumatology: Post Author Corrections: August 15, 2017, doi: 10.1097/RHU.0000000000000563
Akbar, Umair BS; Yang, Melissa BS; Kurian, Divya BS; Mohan, Chandra Overview Osteoarthritis and Vitamin D))MD, PhD


 Download the PDF from VitaminDWiki

Many clinical trials of omega-3 fatty acids, supplied as fish oil supplements, have been carried out in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), lupus nephritis, and osteoarthritis (OA) over the past 3 decades. This review attempts to summarize the highlights of these studies to evaluate the clinical efficacy for omega-3 fatty acids to be added alongside existing treatment regimens.

A total of 20 clinical trials have been carried out in RA, of which 16 exhibited significant improvements in multiple disease clinical outcomes.
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Nine clinical trials have been completed in SLE and lupus nephritis, of which 6 exhibited significant improvements in 1 or more clinical outcomes.
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A total of 4 clinical trials have been conducted in OA, of which 3 exhibited significant improvements in at least 1 clinical parameter.
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Multiple mechanisms for the clinical effects of omega-3 fatty acids have been implicated, including the modulation of eicosanoid synthesis toward a more anti-inflammatory profile and suppressed production of proinflammatory cytokines. Overall, fish oil supplements appear to be a safe and effective agent that could be added to the current treatment regimens in RA. Longer-term trials with larger patient cohort sizes are warranted to establish any long-term benefits of fish oil supplements in SLE, lupus nephritis, and OA.

Created by admin. Last Modification: Sunday August 20, 2017 11:33:57 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
8319 Omega-3 OA.jpg admin 20 Aug, 2017 10:58 79.04 Kb 335
8318 Omega-3 SLE.jpg admin 20 Aug, 2017 10:57 123.77 Kb 388
8317 Omega-3 RA.jpg admin 20 Aug, 2017 10:57 222.50 Kb 440
8316 Omega_3_Fatty_Acids_in_Rheumatic_Diseases__A.99470.pdf PDF 2017 admin 20 Aug, 2017 10:56 198.35 Kb 227
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