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MSG induces weight gain in female rats not supplemented with active vitamin D – April 2017

Protective Role of Co-administration of Vitamin D in Monosodium Glutamate Induced Obesity in Female Rats

Journal of the National Medical Association, online 14 April 2017, http://doi.org/10.1016/j.jnma.2017.03.006
Padmanabha Nandana, Arun Kumar Nayanatara, Ph.D.a, , , Roopesh Poojary, M.Sc.a, K. Bhagyalakshmi, M.D.a, M. Nirupama, M.D.b, Rekha D. Kini, Ph.D.a

Purpose
Obesity in females is an emerging health problem. The consumption of MSG has been considered as a risk factor for obesity. The tastemakers in Chinese and fast foods, such as fish sauce and soy sauce, contain very high levels of glutamate. The deficiency of Vitamin D is associated with obesity and metabolic syndrome. Therefore, the present study aimed to determine the effect of co-administration of Vitamin D on body weight control in MSG-induced obese rats.

Methods
Eighteen adult female Wistar rats were randomly divided into three groups equally. The first group (Group I) was treated with saline served as the control; the second group (Group II) received a daily oral dose of 5 g/kg Body weight of MSG; the third group (Group III) received the same dose of MSG along with calcitriol (0.2 mcg/kg BW) for 15 days.

Results
The body weight, food, and water intake were measured. MSG treated rats showed a significant increase (P < 0.001) in the body weight, food, and water intake but significant decrease (P < 0.001) was observed in the rats treated with MSG along with Vitamin D.

Conclusion
Ingestion of Vitamin D suppresses body weight gain in MSG-induced obese rats. Active agents in Vitamin D are useful for the prevention and treatment of obesity. Foods tested with high glutamate levels can be fortified with minute quantities of calcitriol to combat the adverse effects without compromising on the taste of the food processed. The fortification of junk foods might also combat largely prevalent Vitamin D deficiency in India.


See also VitaminDWiki


Overview Obesity and Vitamin D contains the following summary

See also web

  • MSG linked to weight gain 2011
    "Americans' typical daily intake of MSG is estimated to be only about half a gram. . . "
    "In the latest research, published in the American Journal of Clinical Nutrition, He and his colleagues followed more than 10,000 adults in China for about 5.5 years on average."
    "Men and women who ate the most MSG (a median of 5 grams a day) were about 30 percent more likely to become overweight by the end of the study than those who ate the least amount of the flavoring (less than a half-gram a day), . . . "


Note: the study on this page gave rats about 50X more MGS per body weight than the Chinese.

Note: suspect that regular (non-activated) Vitamin D would also have stopped MSG weight gain

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