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Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016

Effect of various doses of vitamin D supplementation on pregnant women with gestational diabetes mellitus: A randomized controlled trial

Experimental and Theraputic Medicine, September 2016, Volume 12 Issue 3, DOI: 10.3892/etm.2016.3515
Qingying Zhang Yan Cheng Mulan He Tingting Li Ziwen Ma Haidong Cheng

VitaminDWiki Summary

Insulin
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HOMA-IR
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TAC (antioxident)
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GSH (antioxident)
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GDM detected before week 12
Dosing from week 24-28 of pregnancy to women not getting any other treatment

Control Low doseMedium DoseHigh dose
Dose 0 200 IU daily 50,000 IU
every 4 weeks
50,000 IU
every 2 weeks
Avg daily 0 IU 200 IU1,800 IU3,600 IU

See also VitaminDWiki

Pages listed in BOTH the categories Diabetes and Pregnancy

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

 Download the PDF from VitaminDWiki

It has previously been reported that the influence of vitamin D on the metabolism of calcium and phosphorus is associated with diabetes, cardiovascular disease, Alzheimer's disease, cancer and other systemic diseases, and is considered an important indicator of general health. The present study was conducted to determine the effect of various doses of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation and the levels of oxidative stress of pregnant women with gestational diabetes mellitus (GDM). The present randomized, double-blind placebo-controlled clinical trial was conducted on 133 pregnant women with GDM during weeks 24-28 of pregnancy. The patients were randomly divided into four groups. The control group (n=20) received a placebo (sucrose; one granule/day), the low dosage group (n=38) received the daily recommended intake of 200 IU vitamin D (calciferol) daily, the medium dosage group (n=38) received 50,000 IU monthly (2,000 IU daily for 25 days) and the high dosage group (n=37) received 50,000 IU every 2 weeks (4,000 IU daily for 12.5 days). The general characteristics and dietary intakes of the patients with GDM were similar between each group. Using ELISA kits, it was determined that insulin, homeostatic model assessment-insulin resistance and total cholesterol were significantly reduced by high dosage vitamin D supplementation (P<0.05). Total antioxidant capacity and total glutathione levels were significantly elevated as a result of high dosage vitamin D supplementation (P<0.01). In conclusion, high-dose vitamin D supplementation (50,000 IU every 2 weeks) significantly improved insulin resistance in pregnant women with GDM.

Attached files

ID Name Comment Uploaded Size Downloads
7032 GSH.jpg admin 03 Sep, 2016 15:08 12.33 Kb 447
7031 TAC.jpg admin 03 Sep, 2016 15:08 11.73 Kb 485
7030 HOMA-IR.jpg admin 03 Sep, 2016 15:07 10.79 Kb 415
7029 Insulin.jpg admin 03 Sep, 2016 15:07 10.95 Kb 377
7028 Gestational Diabetes RCT.pdf PDF 2016 admin 03 Sep, 2016 15:03 719.74 Kb 248
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