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50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015


Supplementation of Vitamin D in pregnancy and its correlation with feto-maternal outcome

Clinical Endocrinology, DOI: 10.1111/cen.12751
Aanchal Sablok1,*, Aruna Batra1, Karishma Thariani1, Achla Batra1, Rekha Bharti1, Abha Rani Aggarwal2, B C Kabi3 and Harish Chellani4
1 Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
2 National Institute of Medical Statistics, All India Institute of Medical Sciences, New Delhi, India
3 Department of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
4 Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
* Corresponding author: Dr Aanchal Sablok, Senior Resident, Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. 110029, India. aanchalsablok54 at gmail.com

VitaminDWiki Summary
ControlIntervention
Vitamin D Level 18 ng 32 ng
Preterm labor
or Pre-eclampsia
or Gestational Diabetes
44 % 20 %
Birth weight 2.4 kg2.6 kg

 Download the PDF from VitaminDWiki

Context: Vitamin D deficiency widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency.

Objective: 1) To find prevalence of vitamin D deficiency in pregnant women. 2) To evaluate effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.

Design: Randomized control trial from years 2010-2012.

Setting: Tertiary care centre, Delhi, India.

Participants: 180 pregnant women. Study population divided randomly into 2 groups; Group A: non-intervention (60 women) and Group B: intervention (120 women).

Intervention: The intervention group received supplementation of vitamin D in dosages depending upon 25(OH)-D levels.

Main Outcome measures: Risk of maternal complications like Pre-term labour; pre-eclampsia and gestational diabetes associated with Vitamin D deficiency and risk of Low birth weight and poor APGAR score in infants of mothers with Vitamin D deficiency.

Results: Adjusted serum 25(OH)-D concentration was lower in group A as compared to group B (mean 46.11 ± 74.21 nmol/L vs 80 ± 51.53 nmol/L). 44% patients in group A and 20.3% patients in group B developed Pre-term labour/Pre-eclampsia/Gestational Diabetes. New-borns of mothers in group A had lower cord blood levels of 25(OH)-D levels as compared to group B (mean 43.11 ± 81.32 nmol/L vs 56.8 ± 47.52 nmol/L). They also had lower birth weight of mean 2.4 ± 0.38 kg as compared to group B 2.6 ± 0.33 kg.

Conclusions: Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.


See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


VitaminDWiki with GESTATIONAL DIABETES in title (36 as of July 2022)

This list is automatically updated

Items found: 38
Title Modified
Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022 07 Aug, 2022
Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022 14 Jul, 2022
Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021 14 Jul, 2022
Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 31 May, 2022
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
Vitamin D reduces pre-eclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 05 Dec, 2021
50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015 15 Aug, 2020
300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011 25 Jul, 2020
Vitamin D cuts pregnancy risks in half – low birth weight, preeclampsia, gestational diabetes – Cochrane July 2019 12 Sep, 2019
Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019 24 Jun, 2019
Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018 14 Jun, 2019
Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019 18 May, 2019
Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012 23 Mar, 2019
Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019 23 Mar, 2019
Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018 17 Mar, 2018
Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015 07 Feb, 2018
Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017 02 Jan, 2018
Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007 30 Dec, 2017
Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017 15 Dec, 2017
Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017 15 Dec, 2017
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015 09 Nov, 2017
Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017 04 Oct, 2017
Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016 07 Jun, 2017
Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016 04 Jan, 2017
Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016 10 Dec, 2016
Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014 03 Sep, 2016
Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016 03 Sep, 2016
Infant much healthier if Gestational Diabetic mother got 2 doses of vitamin D – RCT Nov 2014 09 Apr, 2016
Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016 16 Jan, 2016
Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015 13 Jan, 2016
Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 02 Oct, 2015
Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015 01 Jul, 2015
Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014 14 Apr, 2015
Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014 02 Mar, 2015
Gestational Diabetes mostly treated with just 2 doses of 50,000 IU of vitamin D – RCT Dec 2013 26 Jun, 2014
Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013 31 Aug, 2013
Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012 15 Nov, 2012


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