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300,000 IU Vitamin D injection before brain tumor surgery – RCT to finish Dec 2017

Clinical Trial Entry: Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery


Results: Following brain surgery Vitamin D injections did not raise blood levels much – RCT June 2019
Not clear when the vitamin D injection will be given – hopefully >3 days before the surgery
60 patients – including the 30 controls who will not get any Vitamin D


VitaminDWiki

Expects that there will be very few RCT’s like this in the future.
It will become morally wrong to not give Vitamin D to all surgery, ICU, etc. patients

Overview Loading of vitamin D contains the following

Loading dose: 155 studies at VitaminDWiki

Vitamin D loading dose (stoss therapy) proven to improve health overview
If a person is or is suspected to be, very vitamin D deficient a loading dose is typically given

  • Loading = restore = quick replacement by 1 or more doses
  • Loading doses range in total size from 100,000 IU to 1,000,000 IU of Vitamin D3
    • = 2.5 to 25 milligrams
  • The size of the loading dose is a function of body weight - see below
    • Unfortunately, some doctors persist in using Vitamin D2 instead of D3
  • Loading may be done as quickly as a single day (Stoss), to as slowly as 3 months.
    • It appears that spreading the loading dose over 4+ days is slightly better if speed is not essential
  • Loading is typically oral, but can be Injection (I.M,) and Topical
  • Loading dose is ~3X faster if done topically or swished inside of the mouth
    • Skips the slow process of stomach and intestine, and might even skip liver and Kidney as well
  • The loading dose persists in the body for 1 - 3 months
    • The loading dose should be followed up with on-going maintenance dosing
    • Unfortunately, many doctors fail to follow-up with the maintenance dosing.
  • About 1 in 300 people have some form of a mild allergic reaction to vitamin D supplements, including loading doses
    • it appears prudent to test with a small amount of vitamin D before giving a loading dose
    • The causes of a mild allergic reaction appear to be: (in order of occurrence)
    • 1) lack of magnesium - which can be easily added
    • 2) allergy to capsule contents - oil, additives (powder does not appear to cause any reaction)
    • 3) allergy to the tiny amount of D3 itself (allergy to wool) ( alternate: D3 made from plants )
    • 4) allergy of the gut to Vitamin D - alternative = topical

Injection category contains the following

{SQL(db=>vitamind)}SELECT COUNT(*) FROM `tiki_category_objects` WHERE `categId`=165{SQL} items in Vitamin D Injection category

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{img src="display2696" link="Getting Vitamin D into your body"}

  • Injections are currently made by medical professionals into muscle
  • Home injection of Vitamin D appears to be possible in the future
  • Injections are useful for people who might forget to take their periodic supplement (children, elderly, etc) and those who cannot swallow or have poor digestion
  • While Vitamin D2 is historically the common form, Vitamin D3 is far better
  • Should check (if there is time) for possible allergic reaction to Vitamin D or lack of Magnesium for both for loading dose and injection
  • Note 600,000 IU Vitamin D loading dose via capsules is 1/20th the cost($2.40) of an injection, and does not require a prescription
  • 100,000 IU single dose of vitamin D - 2010 has the following
    {img type="attId" attId="5984" width="400"}
  • Vitamin D injection lasts longer and has bigger response than weekly oral – Jan 2017 has the following
    {img type="attId" attId="7560" width="400"}

Created by admin. Last Modification: Tuesday June 11, 2019 12:50:49 GMT-0000 by admin. (Version 6)
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