Table of contents
- Human Herpesvirus 6A Is a Risk Factor for Multiple Sclerosis - 2022
- The role of herpesvirus 6A and 6B in multiple sclerosis and epilepsy - 2020
- Herpesviruses are extremely prevelant
- Human herpesvirus 6 "multiple sclerosis" 27,000 publications as of Feb 2022
- hhv-6 Foundation
- Evidence linking HHV-6 with multiple sclerosis (2014) - cited by 111 studies as of Feb 2022
- VitaminDWiki -
12 MS and Virus studies - VitaminDWiki - Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019
- VitaminDWiki - human herpesvirus are enveloped
- Vitamin D TREATS Health problems: 40 ng ...150 ng
- VitaminDWiki - Epstein-Barr Virus probably causes Long-COVID, CFS, and MS - many studies
Human Herpesvirus 6A Is a Risk Factor for Multiple Sclerosis - 2022
Review Front Immunol . 2022 Feb 10;13:840753. doi: 10.3389/fimmu.2022.840753. eCollection 2022.
Wangko Lundström 1, Rasmus Gustafsson 1
The role for human herpesvirus (HHV)-6A or HHV-6B in multiple sclerosis (MS) pathogenesis has been controversial. Possibly because the damage of the virus infection may occur before onset of clinical symptoms and because it has been difficult to detect active infection and separate serological responses to HHV-6A or 6B. Recent studies report that in MS patients the serological response against HHV-6A is increased whereas it is decreased against HHV-6B. This effect seems to be even more pronounced in MS patients prior to diagnosis and supports previous studies postulating a predomination for HHV-6A in MS disease and suggests that the infection is important at early stages of the disease.
Furthermore, HHV-6A infection interacts with other factors suspected of modulating MS susceptibility and progression such as infection with- Epstein-Barr virus (EBV) and
- Cytomegalovirus (CMV),
- tobacco smoking,
- HLA alleles,
- UV irradiation and
- vitamin D levels.
The multifactorial nature of MS and pathophysiological role for HHV-6A in inflammation and autoimmunity are discussed.
CONCLUSIONS - from PDF
Together, the studies compiled in this review suggest a role for HHV-6A in MS, particularly early in the disease course and/or at MS onset. This is based on findings of increased anti-HHV-6A antibody levels in people who developed MS later in life, compared to people who do not. HHV-6A infection interacts with other risk factors such as carriage of HLA-DRB1*15:01, tobacco smoking, low UV irradiation, low vitamin D levels and EBV infection; and with protective factors such carriage of the protective haplotype HLA-A*02:01 and CMV infection. This shows the multifactorial nature of MS and suggests that accumulated burden of risk factors increases the risk for acquiring the disease. We propose a pathophysiological role for HHV-6A in induction of MS where an infection of the CNS leads to a primary injury and that this in turn leads to inflammatory events and autoimmunity.
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The role of herpesvirus 6A and 6B in multiple sclerosis and epilepsy - 2020
Scand J Immunol. 2020 Dec; 92(6): e12984 doi: 10.1111/sji.12984
Nicky Dunn, 1 , 2 Nastya Kharlamova, 1 , 2 and Anna Fogdell‐Hahncorresponding author 1 , 2Human herpesvirus 6A (HHV‐6A) and 6B (HHV‐6B) are two closely related viruses that can infect cells of the central nervous system (CNS). The similarities between these viruses have made it difficult to separate them on serological level. The broad term HHV‐6 remains when referring to studies where the two species were not distinguished, and as such, the seroprevalence is over 90% in the adult population. HHV‐6B has been detected in up to 100% of infants with the primary infection roseola infantum, but less is known about the primary infection of HHV‐6A. Both viruses are neurotropic and have capacity to establish lifelong latency in cells of the central nervous system, with potential to reactivate and cause complications later in life. HHV‐6A infection has been associated with an increased risk of multiple sclerosis (MS), whereas HHV‐6B is indicated to be involved in pathogenesis of epilepsy. These two associations show how neurological diseases might be caused by viral infections, but as suggested here, through completely different molecular mechanisms, in an autoimmune disease, such as MS, by triggering an overreaction of the immune system and in epilepsy by hampering internal cellular functions when the immune system fails to eliminate the virus. Understanding the viral mechanisms of primary infection and reactivation and their spectrum of associated symptoms will aid our ability to diagnose, treat and prevent these severe and chronic diseases. This review explores the role of HHV‐6A and HHV‐6B specifically in MS and epilepsy, the evidence to date and the future directions of this field.
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Herpesviruses are extremely prevelant
Antibiotic, Antifungal, Antiviral Drugs - Herpesviruses
Human herpesvirus 6 "multiple sclerosis" 27,000 publications as of Feb 2022
hhv-6 Foundation
https://hhv-6foundation.org/
Autoimmune Disease
Cancer
Hodgkin’s Lymphoma
Gliomas
Cervical Cancer
Chronic Fatigue Syndrome
Cognitive Dysfunction
Delirium
Amnesia
Colitis/Diarrhea
Encephalitis
Encephalitis / Meningitis Overview
Encephalitis in the Immunocompromised
Encephalitis in the Immunocompetent
Rhomboencephalitis
Limbic Encephalitis
Encephalomyelitis
Amnesia
Endocrine Disorders
Epilepsy
Mesial/Temporal Lobe Epilepsy
Status Epilepticus
Heart Disease
Myocarditis
Left Ventricle Disfunction
Arteriopathies
Hemophagocytic Conditions
Hemophagocytic Syndrome/ Histiocytosis
HIV/AIDS Progression
Hypersensitiity (DIHS/DRESS)
Drug Induced Hypersensitivity Syndrome (DIHS)
Drug Reaction with Eosinophilia & Systemic Symptoms (DRESS)
Stevens-Johnson Syndrome (SJS)
Immune Suppression
Bone Marrow Suppression
Kidney Disease
Liver Disease
Hepatitis
HIV/AIDS Progression
Lung Disease
Organizing Pneumonia
Pneumonitis
Lymphadenopathy/Fever
Multiple Sclerosis
Evidence linking HHV-6 with multiple sclerosis: an update- 2014  PDF
Rash & Roseola
Seizures
Febrile Seizures
Status Epilepticus
Transplant Complications
Bone marrow supression
Colitis/diarrhea
Delirium/CNS Dysfunction
Encephalitis/Amnesia
GVHD
Hemophagocytic syndrome
Hepatitis /Liver failure
Pneumonitis
Transplant Reactivation Overview
SIADH
Hypogammaglobulinemia
Optic Neuritis
Microangiopathy
Mononucleosis
Uveitis
Evidence linking HHV-6 with multiple sclerosis (2014) - cited by 111 studies as of Feb 2022
 PDF
Google Scholar examples- Laboratory and clinical aspects of human herpesvirus 6 infections
- Infection as an environmental trigger of multiple sclerosis disease exacerbation
- Update on infections with human herpesviruses 6A, 6B, and 7
- Presence of HHV-6A in endometrial epithelial cells from women with primary unexplained infertility
- The role of infections in multiple sclerosis
- Multiple sclerosis and neuroinflammation: the overview of current and prospective therapies
- Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology
- Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation
VitaminDWiki -
12 MS and Virus studies This list is automatically updated
- COVID infections or vaccinations may increase Multiple Sclerosis (if low D) - several studies
- Autoimmune diseases caused in first day after COVID Vaccination - Oct 2023
- Epstein-Barr Virus may be a prerequisite for Multiple Sclerosis - July 2023
- Diseases treated by high-dose Vitamin D - many studies
- 36% of Multiple Sclerosis patients got worse after mild to severe COVID– June 2022
- Multiple Sclerosis Risk factors include virus such as Human Herpesvirus 6A – many studies
- Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022
- COVID death rate was 3X lower in those with Multiple Sclerosis (85 pcnt were taking Vitamin D) - Jan 2022
- Multiple Sclerosis risk increased if both Epstein-Bar Virus and low sun (vitamin D) – Aug 2021
- Multiple Sclerosis patients had fewer COVID-19 problems (Note: many MSers take Vitamin D) – April 30, 2021
- Infectious mononucleosis and lack of UV linearly linked to MS in England – April 2011
- Multiple Sclerosis etc. strongly associated with Epstein-Barr virus (and vitamin D)
VitaminDWiki - Multiple Sclerosis 32 percent less likely among those with more than 32 ng of vitamin D – Dec 2019
- Overview MS and vitamin D
- An opportunity - use Vitamin D to treat Multiple Sclerosis (has been used for 14 years) - Feb 2022
- Multiple Sclerosis treated when use high doses of vitamin D – meta-analysis May 2018
- Multiple Sclerosis: 10 percent fewer relapses for each 10 ng higher level of vitamin D – Meta-analysis April 2020
- Multiple Sclerosis: number needed to treat with vitamin D may be as low as 1.3 – Meta-analysis Oct 2013
- Multiple Sclerosis more likely if poor vitamin D genes - 22nd study – Aug 2017
- Multiple Sclerosis relapses cut in half by 100,000 IU of Vitamin D every 2 weeks– RCT 2019
UV and Sunshine reduces MS risk
- Multiple Sclerosis 2X more likely if low winter UV – June 2018
- Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018
Other things also help
- Multiple Sclerosis treated by 50,000 IU Vitamin D bi-weekly plus Omega-3 – RCT July 2018
- Multiple Sclerosis 40 percent less likely if consume tinned fish (Vitamin D and Omega-3) – Sept 2019
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Not a single case of multiple sclerosis in 15,000,000 people (plant-based diets)
High Dose Vitamin D and cofactors
- Coimbra protocol using high-dose Vitamin D is safe – April 2022
- The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019
- Comparing High-dose vitamin D therapies MS and other health problems
Number of MS studies which are also in other categories
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22 studies in Genetics - genes can restrict Vitamin D getting to the blood and to the cells 12 studies in Vitamin D Receptor - gene which restricts D from getting to the cells 7 studies in Vitamin D Binding Protein - gene which restricts D from getting to the cells 21 studies in Ultraviolet light - may be even better than Vitamin D in preventing and treating MS 9 studies in Omega-3 - which helps Vitamin D prevent and treat MS
VitaminDWiki - human herpesvirus are enveloped
- Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Zoster, Epstein, Hepatitis, RSV) – March 2011
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
Vitamin D TREATS Health problems: 40 ng ...150 ng
Vitamin D Treats 150 ng Multiple Sclerosis * 80 ng Cluster Headache *
Reduced office visits by 4X *70 ng Sleep * 60 ng Breast Cancer death reduced 60%
Preeclampsia RCT50 ng COVID-19
Fertility
Psoriasis
Infections Review
Infection after surgery40 ng Breast Cancer 65% lower risk
Depression
ACL recovery
Hypertension
Asthma?30 ng Rickets * Evolution of experiments with patients, often also need co-factors
VitaminDWiki - Epstein-Barr Virus probably causes Long-COVID, CFS, and MS - many studies
Multiple Sclerosis Risk factors include virus such as Human Herpesvirus 6A – many studies124408 visitors, last modified 17 Oct, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 17139 Scand J Immunol - 2020 - Dunn - The role of herpesvirus 6A and 6B in multiple sclerosis and epilepsy.pdf admin 28 Feb, 2022 189.99 Kb 408 17138 Evidence linking HHV-6 to MS - 2014.pdf admin 28 Feb, 2022 504.15 Kb 383 17137 HHV prevelence.jpg admin 28 Feb, 2022 69.79 Kb 821 17136 HHV-6A MS.jpg admin 28 Feb, 2022 57.63 Kb 831 17134 Human Herpesvirus 6A and MS.pdf admin 28 Feb, 2022 442.22 Kb 407