Calcifediol (semi-activated Vitamin D) might treat Respiratory Diseases such as COVID - July 2022

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Calcifediol for Use in Treatment of Respiratory Disease

Nutrients 2022, 14, 2447. https://doi.org/10.3390/ nu14122447
Marta Entrenas-Castillo 2, Lourdes Salinero-González 3, Luis M. Entrenas-Costa 1,2, 4 and Rubén Andújar-Espinosa 5,6,*@
1 Pneumology Department, Hospital QuironSalud, 14004 Cordoba, Spain; marenca at gmail.com (M.E.-C.); luis.m.entrenas at gmail.com (L.M.E.-C.)
2 School of Medicine, University of Córdoba, 14071 Cordoba, Spain
3 Endocrinology and Nutrition Department, Hospital Universitario Reina Sofía, 30003 Murcia, Spain; lourdessalinero at hotmail.com
4 Pneumology Department, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain
5 Pneumology Department, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain
6 Medicine Department, University of Murcia, 30120 Murcia, Spain * Correspondence: rubemed at hotmail.com

PDF Table of Contents

Calcifediol is the prohormone of the vitamin D endocrine system (VDES). It requires hydroxylation to move to 1,25(OH)2D3 or calcitriol, the active form that exerts its functions by activating the vitamin D receptor (VDR) that is expressed in many organs, including the lungs. Due to its rapid oral absorption and because it does not require first hepatic hydroxylation, it is a good option to replace the prevalent deficiency of vitamin D (25 hydroxyvitamin D; 25OHD), to which patients with respiratory pathologies are no strangers. Correcting 25OHD deficiency can decrease the risk of upper respiratory infections and thus improve asthma and COPD control. The same happens with other respiratory pathologies and, in particular, COVID-19. Calcifediol may be a good option for raising 25OHD serum levels quickly because the profile of inflammatory cytokines exhibited by patients with inflammatory respiratory diseases, such as asthma, COPD or COVID-19, can increase the degradation of the active metabolites of the VDES. The aim of this narrative revision is to report the current evidence on the role of calcifediol in main respiratory diseases. In conclusion, good 25OHD status may have beneficial effects on the clinical course of respiratory diseases, including COVID-19. This hypothesis should be confirmed in large, randomized trials. Otherwise, a rapid correction of 25(OH)D deficiency can be useful for patients with respiratory disease.
here endogenous synthesis is profoundly impaired (such as in vulnerable groups of people, including newborns, infants, people who cover their skin for religious or cultural reasons or those with dark skin, especially if they live in northern countries, and in elderly people confined to the home, such as nursing home residents, etc.) [1]. Vitamin D is part of an endocrine system, the vitamin D endocrine system (VDES), in much the same way as other steroid hormones. Calcifediol is a prohormone of this endocrine system and is produced mainly after hepatic hydroxylation of vitamin D3 (cholecalciferol). In order to convert to the active hormonal form (calcitriol), new hydroxylation by the enzyme 25(OH)D-1a-hydroxylase is necessary [2,3] (Figure 1).
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VitaminDWiki - Calcidiol contains

47 items in Calcidiol category

Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
See also

• Calcifediol (Calcidiol, semiactivated Vitamin D) - many studies 55 as of Jan 2024
• Tests for Vitamin D 157 items
• Calcitriol 56 items
• Injection 62 items
• Forms of Vitamin D 110 items
• Response to Vitamin D - many studies 186 as of June 2024
• Nanoemulsion Vitamin D is faster and better - many studies
  • Response to Nanoemulstion Vitamin D swished in the mouth appears to start in 2 hours
• Calcidiol is available only by prescription and is expensive
• Calcidiol - daily dose has fast response, but weekly might be better - March 2018

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VitaminDWiki - 8 studies in both categories Virus and Calcidiol

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82+ VitaminDWiki pages have RESPIRATORY in title

Note: Calcidiol is rarely listed
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