Sleep disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017

The effect of vitamin D supplement on the score and quality of sleep in 20-50 year-old people with sleep disorders compared with control group.

Nutr Neurosci. 2017 May 5:1-9. doi: 10.1080/1028415X.2017.1317395. [Epub ahead of print]
Majid MS1, Ahmad HS1, Bizhan H1, Mohammad Hosein HZ2, Mohammad A3.

• 1 Dept of Nutritional Science, Paramedical Faculty , Ahvaz Jundishapur Medical Sciences University , Ahvaz , Iran.
• 2 Dept Biostatistics, School of Health , Ahvaz Jundishapur University of Medical Science , Ahvaz , Iran.
• 3 Department of Nutritional Science , Arvand International Division of Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Description of the study at Examine.com

includes the following data (made into a table by VitaminDWiki)

	Vitamin D 50K every 14 days	Placebo
Sleep duration	6.5 hours	5.2 hours
Time to fall asleep	33 minutes	59 minutes
% of time in bed spent asleep	87%	81%
Subjective sleep quality   Smaller is better	1.2	1.5

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 Download the PDF from SciHub via VitaminDWiki

• Numbers have been reported as percentage or mean ± SD.
• P1: comparison of mean and SD of anthropometric indexes between two groups of vitamin D recipients and placebo recipients (independent sample t-test for hip circumference and weight variables and Mann–Whitney U statistical test for other variables).
• P2: comparison of mean and SD of anthropometric indexes between two groups of vitamin D recipients and placebo recipients after modifying job effect (ANCONA statistical test).
• P3: comparison of mean and SD of anthropometric indices in each group at the beginning and at the end of the study (paired sample t-test for weight, BMI and pelvic circumference variables and Wilcoxon statistical test for other variables).

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OBJECTIVES:
Sleep quality may be directly related with vitamin D serum level. Some studies found that people with lower vitamin D serum level experienced a lower sleep quality. Consequently, this study aimed at determining the effect of vitamin D supplements on sleep score and quality in 20-50 year-old people with sleep disorders.

METHODS:
This double blind, clinical trial was performed in November 2015-February 2016 on 89 people with sleep disorders based on Petersburg's Sleep Index. Patient samples were divided randomly into two groups: intervention and placebo. At the end of the study, the data on 89 subjects (44 in intervention group and 45 people in placebo group) were examined. Intervention group received a 50 000-unit vitamin D supplement, one in a fortnight for 8 weeks. Meanwhile, placebo group received placebo. Before and after intervention, Petersburg's Sleep Quality Questionnaire, International Physical Activity Questionnaire, general information questionnaire, sun exposure, vitamin D serum level and 3-day food record questionnaire were assessed and recorded for all participants. To analyze data, t-test, chi square, ANCOVA, U-Mann-Whitney and Wilcoxon statistical tests were used.

FINDINGS:
Based on the results of the present study, at the end of the study sleep score (PSQI) reduced significantly in vitamin recipients as compared with placebo recipients (P < 0.05). This difference was significant even after modifying confounding variables (P < 0.05).

CONCLUSION:
This study shows that the use of vitamin D supplement improves sleep quality, reduces sleep latency, raises sleep duration and improves subjective sleep quality in people of 20-50 year-old with sleep disorder.

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