Plasma 25-Hydroxyvitamin D and Mortality in Patients With Suspected Stable Angina Pectoris
The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 3, 1 March 2018, Pages 1161–1170, https://doi.org/10.1210/jc.2017-02328
Eirik Degerud Ottar Nygård Stefan de Vogel Rune Hoff Gard Frodahl Tveitevåg Svingen Eva Ringdal Pedersen Dennis Winston Trygve Nilsen Jan Erik Nordrehaug Øivind Midttun Per Magne Ueland
- Note: 70-80% were taking statins, which is known to decrease vitamin D from the sun
- Speculation: Those patients who had a good level of vitamin D (> 40ng) at the start had gotten it from the sun.
Statins will have greatly reduced their vitamin which they would get from the sun.
There were no vitamin D measurements near the time of death to confirm or refute this hypothesis - Wonder if long-term use of baby aspirin by half ot adults > age 65 reduces vitamin D
- Wonder if long-term use of blood thinners reduces Vitamin D levels
- Cardiovascular deaths 12 percent less likely if have 10 ng more vitamin D – meta-analysis March 2017
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Health problems prevented by eating nuts (perhaps due to Magnesium and or Omega-3) – meta-analysis Dec 2016
- Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
- Is too much vitamin D bad – possible causes and cures
Cardiovascular category starts with the following
Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022
- Overview Cardiovascular and vitamin D
- Cardiovascular Disease is treated by Vitamin D - many studies 39+ meta-analyses
- Coronary Artery Disease and Vitamin D - many studies 18+
- Cardiovascular problems reduced by Omega-3 - many studies 34+
- Arteries and Atherosclerosis and Vitamin D - many studies 71+
- Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 26+
- Statins and Vitamin D - many studies 25+
- Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- Giving free vitamin D to every Iranian would pay for itself by just reducing CVD – Oct 2021
- Sudden Cardiac Arrest – 2.8 X higher risk if low vitamin D – 2019
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- Cardiovascular disease 2.3 X more-likely if poor Vitamin D Receptor – Aug 2022
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and Vitamin D - many studies statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
PDF was available free at Sci-Hub.tv as of March 2018
Context and Objective
Vitamin D status may affect cardiovascular disease (CVD) development and survival. We studied the relationship between concentrations of the circulating biomarker 25-hydroxyvitamin D (25OHD) and all-cause and cardiovascular mortality risk.
Design, Setting, Participants, and Main Outcome Measures
25OHD, the sum of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2, was analyzed in plasma samples from 4114 white patients suspected of having stable angina pectoris and was adjusted for seasonal variation. Hazard ratios (HRs) for all-cause and cardiovascular mortality were estimated by using multivariable Cox models with 25OHD as the main exposure variable, with adjustment for study site, age, sex, smoking, body mass index, estimated glomerular filtration rate, and systolic blood pressure.
Results
A total of 895 (21.8%) deaths, including 407 (9.9%) from CVD causes, occurred during a mean ± standard deviation follow-up of 11.9 ± 3.0 years. Compared with the first 25OHD quartile, HRs in the second, third, and fourth quartiles were
- 0.64 (95% confidence interval (CI), 0.54 to 0.77),
- 0.56 (95% CI, 0.46 to 0.67), and 0.56 (95% CI)
- 0.46 to 0.67) for all-cause mortality
and
- 0.70 (95% CI, 0.53 to 0.91),
- 0.60 (95% CI, 0.45 to 0.79), and
- 0.57 (95% CI, 0.43 to 0.75)
for cardiovascular mortality, respectively.
Threshold analysis demonstrated increased all-cause and CVD mortality in patients with 25OHD concentrations below ∼42.5 nmol/L. Moreover, analysis suggested increased all-cause mortality at concentrations >100 nmol/L.
Conclusion
Plasma 25OHD concentrations were inversely associated with cardiovascular mortality and nonlinearly (U-shaped) associated with all-cause mortality.
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