Table of contents
- Calcifediol for Use in Treatment of Respiratory Disease
- VitaminDWiki - Calcidiol contains
- VitaminDWiki -
8 studies in both categories Virus and Calcidiol - 82+ VitaminDWiki pages have RESPIRATORY in title
- Antibiotics have same benefit as placebo in fighting Lower Respiratory Tract infections - July
Calcifediol for Use in Treatment of Respiratory Disease
Nutrients 2022, 14, 2447. https://doi.org/10.3390/ nu14122447
Marta Entrenas-Castillo 2, Lourdes Salinero-González 3, Luis M. Entrenas-Costa 1,2, 4 and Rubén Andújar-Espinosa 5,6,*@
1 Pneumology Department, Hospital QuironSalud, 14004 Cordoba, Spain; marenca at gmail.com (M.E.-C.); luis.m.entrenas at gmail.com (L.M.E.-C.)
2 School of Medicine, University of Córdoba, 14071 Cordoba, Spain
3 Endocrinology and Nutrition Department, Hospital Universitario Reina Sofía, 30003 Murcia, Spain; lourdessalinero at hotmail.com
4 Pneumology Department, Hospital Universitario Reina Sofía, 14004 Cordoba, Spain
5 Pneumology Department, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain
6 Medicine Department, University of Murcia, 30120 Murcia, Spain * Correspondence: rubemed at hotmail.comPDF Table of Contents
Calcifediol is the prohormone of the vitamin D endocrine system (VDES). It requires hydroxylation to move to 1,25(OH)2D3 or calcitriol, the active form that exerts its functions by activating the vitamin D receptor (VDR) that is expressed in many organs, including the lungs. Due to its rapid oral absorption and because it does not require first hepatic hydroxylation, it is a good option to replace the prevalent deficiency of vitamin D (25 hydroxyvitamin D; 25OHD), to which patients with respiratory pathologies are no strangers. Correcting 25OHD deficiency can decrease the risk of upper respiratory infections and thus improve asthma and COPD control. The same happens with other respiratory pathologies and, in particular, COVID-19. Calcifediol may be a good option for raising 25OHD serum levels quickly because the profile of inflammatory cytokines exhibited by patients with inflammatory respiratory diseases, such as asthma, COPD or COVID-19, can increase the degradation of the active metabolites of the VDES. The aim of this narrative revision is to report the current evidence on the role of calcifediol in main respiratory diseases. In conclusion, good 25OHD status may have beneficial effects on the clinical course of respiratory diseases, including COVID-19. This hypothesis should be confirmed in large, randomized trials. Otherwise, a rapid correction of 25(OH)D deficiency can be useful for patients with respiratory disease.
here endogenous synthesis is profoundly impaired (such as in vulnerable groups of people, including newborns, infants, people who cover their skin for religious or cultural reasons or those with dark skin, especially if they live in northern countries, and in elderly people confined to the home, such as nursing home residents, etc.) [1]. Vitamin D is part of an endocrine system, the vitamin D endocrine system (VDES), in much the same way as other steroid hormones. Calcifediol is a prohormone of this endocrine system and is produced mainly after hepatic hydroxylation of vitamin D3 (cholecalciferol). In order to convert to the active hormonal form (calcitriol), new hydroxylation by the enzyme 25(OH)D-1a-hydroxylase is necessary [2,3] (Figure 1).
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VitaminDWiki - Calcidiol contains
48 items in Calcidiol category Calcidiol = Calcifediol = 25-hydroxyvitamin D3 = 25(OH)D = semi-activated Vitamin D
See also- Calcifediol (Calcidiol, semiactivated Vitamin D) - many studies 55 as of Jan 2024
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160 items - Calcitriol
59 items - Injection
63 items - Forms of Vitamin D
111 items - Response to Vitamin D - many studies 186 as of June 2024
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(~7X more expensive than standard Vitamin D)- Nanoemulsion Vitamin D is faster and better - many studies
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- Calcidiol - daily dose has fast response, but weekly might be better - March 2018
VitaminDWiki -
8 studies in both categories Virus and Calcidiol This list is automatically updated
- Calcifediol (semi-activated Vitamin D) might treat Respiratory Diseases such as COVID - July 2022
- Two times less likely to test positive for COVID if vitamin D level more than 55ng, etc. – Dec 31, 2021
- Large dose of calcifediol or vitamin D up to 15 days before COVID hospitalization reduced death rates (1.5X, 1.3X) – Dec 2021
- Vitamin D trial for COVID-19 – using their patented slow-release form – Aug 2021
- COVID-19 death 40 percent less likely if supplemented with Vitamin D and got above 30 ng (Spain 108,000 people) – July 2021
- 7X less likely to go to ICU if COVID-19 ward gave calcifediol (semi-activated Vitamin D) – July 2021
- 5X less likely to enter ICU with COVID-19 if get Calcifediol (semi-activated vitamin D) - RCT Feb 19, 2021
- COVID-19 defeated by calcifediol form of Vitamin D in Spain - pilot RCT Aug 29, 2020
82+ VitaminDWiki pages have RESPIRATORY in title
Note: Calcidiol is rarely listed
This list is automatically updatedItems found: 83
Antibiotics have same benefit as placebo in fighting Lower Respiratory Tract infections - July
Investigator Points to Study Showing Placebo and Antibiotics Essentially Same Result Against Lower Respiratory Tract Infection or Mild Pneumonia Trial Site news
Treating acute respiratory illness: the need to be proactive, Evangelos J Giamarellos-Bourboulis - Lancet Respiratory Medicine DOI:https://doi.org/10.1016/S2213-2600(24)00168-1 PDF behind paywallCalcifediol (semi-activated Vitamin D) might treat Respiratory Diseases such as COVID - July 20228855 visitors, last modified 14 Jul, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 18134 ToC respiratory.jpg admin 19 Jul, 2022 21.41 Kb 250 18133 Calcifediol_for_Use_in_Treatment_of_Respiratory_Di_CompressPdf.pdf admin 19 Jul, 2022 423.02 Kb 175 - Calcitriol