Vitamins etc, appear to slow down epigenetic aging and reduce inflammation – March 2024

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A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age

Geroscience. 2024 Mar 26. doi: 10.1007/s11357-024-01138-8 – PDF behind paywall, but can be seen in DeepDyve
Kirsty C McGee 1, Jack Sullivan 1, Jon Hazeldine 1, Lisa J Schmunk 2, Daniel E Martin-Herranz 2, Thomas Jackson 1 3, Janet M Lord 4 5

An increase in systemic inflammation (inflammaging) is one of the hallmarks of aging. Epigenetic (DNA methylation) clocks can quantify the degree of biological aging and this can be reversed by lifestyle and pharmacological intervention. We aimed to investigate whether a multi-component nutritional supplement could reduce systemic inflammation and epigenetic age in healthy older adults. We recruited 80 healthy older participants (mean age ± SD: 71.85 ± 6.23; males = 31, females = 49). Blood and saliva were obtained pre and post a 12-week course of a multi-component supplement, containing:

• Vitamin B3,
• Vitamin C,
• Vitamin D,
• Omega 3 fish oils,
• Resveratrol,
• Olive fruit phenols and
• Astaxanthin.

Plasma GDF-15 and C-reactive protein (CRP) concentrations were quantified as markers of biological aging and inflammation respectively. DNA methylation was assessed in whole blood and saliva and used to derive epigenetic age using various clock algorithms.No difference between the epigenetic and chronological ages of participants was observed pre- and post-treatment by the blood-based Horvath or Hannum clocks, or the saliva-based InflammAge clock. However, in those with epigenetic age acceleration of ≥ 2 years at baseline, a significant reduction in epigenetic age (p = 0.015) and epigenetic age acceleration (p = 0.0058) was observed post-treatment using the saliva-based InflammAge clock. No differences were observed pre- and post-treatment in plasma GDF-15 and CRP, though participants with CRP indicative of an elevated cardiovascular disease risk (hsCRP ≥ 3µg/ml), had a reduction in CRP post-supplementation (p = 0.0195).Our data suggest a possible benefit of combined nutritional supplementation in individuals with an accelerated epigenetic age and inflammaging.

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VitaminDwiki – Epigenetics and Vitamin D – many studies

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VitaminDwiki – Longevity and healthspan increased by Vitamin D - many studies

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VitaminDWiki – Inflammation category contains:

171 items total

Example studies

• Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
• COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
• Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
• Vitamin D reduces inflammation in critically ill patients – Sept 2020
• Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
• How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
• CYTOKINE in VitaminDWiki 12 titles as of July 2023
• 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
• Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014

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38+ VitaminDWiki pages have AGING in the title

This list is automatically updated

• How Not To Age book (diet, exercise, supplements) Dr. Greger - Dec 2023