A serum vitamin d level <25nmol/l pose high tuberculosis risk: a meta-analysis.
PLoS One. 2015 May 4;10(5):e0126014. doi: 10.1371/journal.pone.0126014. eCollection 2015.
Zeng J1, Wu G2, Yang W2, Gu X2, Liang W2, Yao Y2, Song Y3.
BACKGROUND:
Low serum Vitamin D is considered to be associated with tuberculosis while the "dangerous" level was not clear. The aim of this study was to identify the association between tuberculosis and serum Vitamin D levels via synthesis of available evidence.
METHODS:
A search of EMBASE, Medline, ISI Web of knowledge, and Pubmed was conducted. The number of subjects of tuberculosis and no-tuberculosis groups in four Vitamin D range. Meta-analyses were performed and presented by odds ratios (ORs) and corresponding 95% confidence intervals (CIs).
RESULTS:
A total of 15 studies involving 1440 cases and 2558 controls were included. A significantly increased risk of tuberculosis was found in two ranges: ≤ 12.5 nmol/L: pooled OR = 4.556, 95% CI = 2.200-9.435; 13-25 nmol/L: pooled OR = 3.797, 95% CI = 1.935-7.405. No statistically significant risk of tuberculosis was found in the range of 26-50 nmol/L (pooled OR = 1.561, 95% CI =0.997-2.442). In range 51-75 nmol/L, no positive association was found (pooled OR =1.160, 95% CI = 0.708-1.900).
CONCLUSIONS:
This study found that a serum Vitamin D level ≤ 25 nmol/L was significantly associated with an increased risk of tuberculosis while the range of 51-75 nmol/L was not. The range 26-50nmol/L posed potential high tuberculosis risk. Future large-scale, well-designed studies are needed to verify these results.
PMID: 25938683
Download the PDF from VitaminDWiki
See also VitaminDWiki
- Overview Tuberculosis and Vitamin D TB has been increasing while vitamin D has been decreasing
- All items in TB and vitamin D
125 items - Less likely to catch Tuberculosis if have OK level of vitamin D – Nov 2014
- Tuberculosis treatment greatly helped by injection of 200,000 IU of vitamin D – RCT April 2016
- Children with active TB were 4.6X more likely to have low vitamin D – Dec 2014 very similar conclusion, has following charts
The TOP TB articles are here:- Immunologic Effects of Vitamin D on Human Health and Disease - Holick July 2020
- Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
- Higher rates of TB in Winter and further from Equator – Nov 2012
- Vitamin D probably can prevent and treat TB and infectious diseases – 2012
- Multidrug-resistant tuberculosis may be reduced with vitamin D – Sept 2012
- TB treatment helped with Vitamin D – RCT Sept 2012
The Meta-analysis of Tuberculosis and Vitamin D
- Latent Tuberculosis 44 percent less likely if Vitamin D more than 30 ng - 14th meta-analysis Jan 2022
- Those with TB were 3.2 X more likely to have low vitamin D – 13th meta-analysis Sept 2021
- Tuberculosis still associated with low vitamin D – 12th meta-analysis June 2021
- Tuberculosis 3X more likely if less than 12 ng of Vitamin D - meta-analysis Sept 2019
- Tuberculosis increased risk if poor Vitamin D receptor varies by race – meta-analysis Feb 2019
- Tuberculosis (multi-drug resistant) was 13.4 X more likely to be quickly cleared with Vitamin D - Meta-analysis Feb 2019
- Catching Tuberculosis from family member 2 X more likely if low vitamin D – meta-analysis Dec 2018
- Tuberculosis in children 1.7 X more likely if low vitamin D – meta-analysis Aug 2018
- Low vitamin D is a risk factor for tuberculosis – meta-analysis Dec 2016
- Tuberculosis 1.3 times more likely if poor Vitamin D Receptor – meta-analysis Oct 2016
- Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015
- Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013
- TB associated with low vitamin D in a review and meta-analysis – 2008
- TB and vitamin D updated review and meta-analysis – plays a role Jan 2010
Tuberculosis 4.5X more likely if vitamin D less than 10 nanogram – meta-analysis May 2015Printer Friendly Follow this page for updates9763 visitors, last modified 30 Dec, 2016, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 5430 TB 5 10 ng.jpg admin 06 May, 2015 79.29 Kb 1711 5429 TB 10 ng.pdf admin 06 May, 2015 631.13 Kb 1074