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- Association between vitamin D and ear Is disease: a meta-analysis and systematic review
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Association between vitamin D and ear Is disease: a meta-analysis and systematic review
The Egyptian Journal of Otolaryngology (2022) 38:27 https://doi.org/10.1186/s43163-022-00199-w
Marzouqi Salamah , Abdullah Alghamdi, Khalid Mania, Rawan Almahyawi 2, Haya Alsubaie 2, Mohamad Alfarghal and Mohammed Algarni 2 Saudi ArabiaBackground: Vitamin D deficiency is a suggested cause and risk factor for various ear diseases. This review assessed the role of vitamin D in ear diseases such as otitis media (OM); this study aimed to assess potential relationships between serum vitamin D level and OM risk; and determined the usefulness of vitamin D supplementation for ear disease prevention and treatment.
Material and methods: This systematic review searched the PubMed, EMBASE, Google Scholar, Web of Science, and the Cochrane Database for studies on vitamin D deficiency as a risk factor for ear diseases. A total of 55 articles were screened based on their titles. The abstracts were then reviewed to identify the 11 articles analyzed in the present study.
Results: Statistical heterogeneity was observed among the 11 studies for subgroup analysis of plasma vitamin D level according to disease type
- acute otitis media [AOM], P < 0.00001;
- chronic *otitis media [COM], P = 0.00001) and
- age (< 5 years, P < 0.00001;
- > 5 years, P < 0.00001).
Heterogeneity was also observed in the frequency of participants with sufficient plasma vitamin D levels according to disease type (AOM, P < 0.00001; COM, P = 0.00001) and age (< 5 years, P < 0.00001; > 5 years, P = 0.003; 12 = 70%: substantial heterogeneity).
Conclusion: Vitamin D deficiency is common in otolaryngology patients, for which supplementation showed promising results. Vitamin D deficiency was associated with the etiopathology of ear diseases in adults and children. We recommend empirical supplementation of vitamin D in otolaryngology patients and further studies investigating this supplementation.
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4 Ear and Infant-Child articles - Many ear problems are strongly associated with low vitamin D – meta-analysis Feb 2022
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