Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children.
Epidemiol Infect. 2018 Jul 30:1-7. doi: 10.1017/S0950268818002066. [Epub ahead of print]
Palframan KM1, Robinson SL1, Mora-Plazas M2, Marin C2, Villamor E1.
1 Department of Epidemiology,University of Michigan School of Public Health,Ann Arbor,MI,USA.
2 Fundación para Investigación en Nutrición y Salud (FINUSAD),Bogotá,Colombia.
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17 items - Vitamin D Binding Protein category listing has
178 items Infant-Child and Vitamin D Binding Protein:
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Higher Vitamin D-binding protein is good (neonates in this case) – Feb 2023
- Poor protein binding gene associated with poor Vitamin D response – RCT Nov 2019
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Decreased response to vitamin D in white children having poor Vitamin D binding gene – Feb 2019
- Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018
- Vitamin D is more bio-available when children are critically ill (less Binding Protein) – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
Tiny portion of data in table in the PDF
Median DBP (nmol/l) 1501 2152 2791 4002 Earache or ear discharge with fever 43 days 14 days 15 days 11 days Ear problem rate per child-year 0.88 0.28 0.30 0.23
Circulating 25-hydroxy vitamin D (25(OH)D) is related to decreased rates of gastrointestinal and ear infections in school-age children. Vitamin D-binding protein (DBP) transports 25(OH)D and exerts immunological functions; however, it is unknown whether DBP is associated with infectious morbidity in children. We quantified plasma DBP concentrations in 540 school-age children at the time of recruitment into a cohort study in Bogotá, Colombia and obtained daily information on infectious morbidity symptoms and doctor visits during the school year. We compared the incidence rates of gastrointestinal and respiratory symptoms across quartiles of DBP concentration by estimating adjusted incidence rate ratios (IRRs) with 95% confidence interval (CI). We also estimated the per cent of the associations between DBP and morbidity that were mediated through 25(OH)D using a counterfactual frame. Mean ± s.d. DBP concentration was 2650 ± 1145 nmol/l. DBP was inversely associated with the rates of diarrhoea with vomiting (IRR for quartiles 2-4 vs. 1 = 0.48; 95% CI 0.25-0.92; P = 0.03) and earache/ear discharge with fever (IRR for quartiles 2-4 vs. 1 = 0.29; 95% CI 0.12-0.71; P = 0.006). The DBP-morbidity associations were not mediated through 25(OH)D. We conclude that plasma DBP predicts lower incidence of gastrointestinal and ear infections in school-age children independent of 25(OH)D.PDF is available free at Sci-Hub 10.1017/S0950268818002066
Ear infections in children 3X more likely if poor vitamin D binding protein – July 2018Printer Friendly Follow this page for updates4056 visitors, last modified 19 Jun, 2019, This page is in the following categories (# of items in each category) - Vitamin D Binding Protein category listing has