15,000 US death per year from NSAIDs (0 deaths from Vitamin D)

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Non-steroidal anti-inflammatory drugs

(NSAIDs) are medicines that are widely used to relieve pain, reduce inflammation, and bring down a high temperature. They're often used to relieve symptoms of headaches, painful periods, sprains and strains, colds and flu, arthritis, and other causes of long-term pain.
NSAIDs – prescription and over-the-counter – account for nearly 10 percent of all drugs prescribed

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List of NSAIDs

NSAIDs at Medicine.net
aspirin
celecoxib (Celebrex)
diclofenac (Cambia, Cataflam, Voltaren-XR, Zipsor, Zorvolex)
ibuprofen (Motrin, Advil)
indomethacin (Indocin)
naproxen (Aleve, Anaprox, Naprelan, Naprosyn)
oxaprozin (Daypro)
piroxicam (Feldene)

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Vitamin D is steroid which has anti-inflammatory properties

No Deaths from Vitamins. Absolutely None – Jan 2015

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Aspirin: 3,000 US deaths per years (mainly seniors) - 2017

 Download the PDF from VitaminDWiki

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VitaminDwiki - Pain - chronic category contains

168 items in category Chronic pain

See also

• Overview Pain and Vitamin D
• Percentage of people with pain increased 25 percent in 18 years – Jan 2019
• Pain not reduced by 60,000 IU monthly vitamin D (need 50,000 IU weekly) – RCT Aug 2023
• Overview Fibromyalgia or Chronic Fatigue and vitamin D
• Overview Rheumatoid Arthritis and vitamin D
• Shingles and vitamin D
• Shin splints decrease with vitamin D
• Migraine and Vitamin D
• Headache category 82 items
• "musculoskeletal pain" 490 items as of Aug 2023
• "chronic fatigue" 240 items have it in title or abstract as of Dec 2024
• Category Back Pain 44 items
• 7 pain studies in VitaminDWiki with KNEE in the title as of Aug 2023 (see below)
• Opioid OR Opiate OR Morphine in the title 14 pages as of Dec 2024

VitaminDwiki - Headache category listing has 48 items

VitaminDwiki - Osteoarthritis category listing has 61 items

VitaminDwiki - Overview Colds and flu and Vitamin D

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VitaminDwiki - Inflammation category contains

175 items total

Example studies

• Vitamin D reduces autoimmune, cardio, and metabolic Inflammation – Nov 2024
• Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
• COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
• Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
• Vitamin D reduces inflammation in critically ill patients – Sept 2020
• Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
• How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
• CYTOKINE in VitaminDWiki 12 titles as of July 2023
• 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
• Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014

Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016

Omega-3 is also good at reducing Inflammation

Note: It can take many months to increase Omega-3 levels

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Vitamin D relieves pain and inflammation when levels are >40 ng/ml
This level is not achieved by a single 50,000 IU dose of vitamin D
Vitamin D nanoemulsion applied topically to the skin or swished in the mouth
appears to start to raise vitamin D levels within hours (does not have to go thru the gut, liver, nor kidneys)
Vitamin D loading (without nanoemulsion)can take days to achieve a useful level

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The dangers of NSAIDs: look both ways - April 2016

 Download the PDF from VitaminDWiki
SNIPS

• "Preventable adverse drug reactions (ADRs) are responsible for 10% of hospital admissions in older people at a cost of around £800 million annually. Non-steroidal anti-inflammatory drugs (NSAIDs) are responsible for 30% of hospital admissions for ADRs, mainly due to bleeding, heart attack, stroke, and renal damage"
• "From the first day of use, all NSAIDs increase the risk of gastrointestinal (GI) bleeding, myocardial infarction, and stroke. NSAIDs reduce prostaglandin synthesis, with differences in the extent of inhibition of the enzymes COX-1 and COX-2. All NSAIDs increase both bleeding and cardiovascular disease (CVD) risk but selective COX-2 inhibitors are more likely to cause cardiovascular events, whereas less selective NSAIDs are more likely to cause GI bleeds. The risk of bleeding and of cardiovascular events is considerably higher in older people, of whom many take medicines known to interact with NSAIDs."
• "NSAIDs affect the cardiovascular, GI, renal, and respiratory systems. NSAIDs reduce the antiplatelet effect of aspirin and have a thrombogenic effect on platelet function. NSAIDs increase systolic blood pressure by 5 mmHg and increase fluid retention. In patients taking coxibs, diclofenac, and higher-dose ibuprofen, these effects cause an excess risk of 7–9 non-fatal and 2 fatal cardiovascular events per 1000 patients per year.2 All NSAIDs double the risk of hospitalisation due to heart failure."
• "NSAID use in patients aged >65 years more than doubles the risk of acute kidney injury in the next 30 days.3"
• "NSAIDs can precipitate bronchospasm and 5–10% of adult patients with asthma will have an acute deterioration in symptoms after taking NSAIDs.4 NSAIDs are also associated with a rise in HbA1c in type 2 diabetes."
• "Comorbidity and polypharmacy increase with age, as does the incidence of chronic musculoskeletal conditions such as osteoarthritis, for which NSAIDs are often prescribed. NSAIDs increase the risk of hospitalisation in older people, and multiple comorbidities and polypharmacy compound the risk of CVD and bleeding events."
• "Bleeding is the better-known consequence with all types of NSAID use. Non-selective NSAIDs increase the risk of a GI bleed 4-fold, whereas COX-2 inhibitors increase this risk 3-fold. Co-prescription of NSAIDs with corticosteroids increases bleeding risk 12-fold, spironolactone 11-fold, and selective serotonin reuptake inhibitors (SSRIs) 7-fold.5 GI bleeds while taking NSAIDs are more likely to be fatal, with a mortality of 21%, whereas in patients not taking NSAIDs it is 7%.6"

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Tylenol/Acetaminophen is the cause of 500 deaths annually in the US - kidney damage